摘要:

Seventy‐three unrelated patients with Behçet disease together with 33 members of seven families with at least two patients per family were tissue typed for 26 antigens of the HLA system. The patients with the complete type of Behçet disease were found to have HLA‐B5 more significanth than healthy individuals. Family studies suggest that the genes closely linked to HLA locus influence the degree of severity of Behçet d

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00558.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Multispecific, cross‐reactive sera can be demonstrated by absorption studies to be of two types; a single antibody that is multivalent, and some that are mixtures of monospecific and multispecific antibody populations. The second type can be separated by a differential absorption technique. The characteristics of these sera that can be separated and the techniques are discusse

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00559.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A method for analysing the results of multiple case family studies is presented. the type of inferences which can be drawn is demonstrated with data from a study on juvenile diabetes mellitus. the situations in which multiple case family studies might prove useful are discussed.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00560.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Day 3–4 PHA stimulated lymphocytes were found to respond against HLA‐D without any period of latency, thus allowing a discriminative MLR reading as early as 24–48 h. The test is therefore characterized by the minute number of responding cells necessary (5 × 103), a one‐way reaction without additional treatment of the stimulating normal lymphocytes (5 × 104), and the rapid obtaining of data. We found the preliminary data testing its concordance with classical HLA‐D typing encouraging and worthy of being tested on a larger scale. Using mitogen stimulated recipient cells stored frozen, HLA‐D matching with potential donors was found to be feasible within 24–48 h. The mechanism of such a prompt response by mitogen stimulated lymphocytes is unknown but appears to be independent of the nature and dose of

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00561.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The present family investigation has shown that genes within the MHS are mainly responsible for the development of psoriasis or psoriasis‐associated arthritic lesions (peripheral arthritis and sacroiliitis). We have hypothetically discussed the possibility that multiple genes, all located within the MHS, act in concert to increase the risk of developing disease to very high levels. This implies that at least two MHS linked genes act in complementary fashion for the development of disease, these genes seem to be able to operate both in the cis and in the trans position. One of these genes would be situated in the chromosomal portion of the MHS which carries the HLA‐D locus.Families with a high incidence of disease would show inheritance according to the cis position of genes, when it can be shown that most of the carriers of the specific disease‐associated haplotype are affected by disease, whereas in other families, complementarity between two distinct HLA haplotypes with genes acting in the trans position would result in di

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00562.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In the serum of a young normal male, never transfused, a cold cytotoxic IgM antibody was found reacting exclusively with A2 homozygous cells on a French panel, as shown by population and family studies. This antibody needs about two to five times more lymphocytes or platelets to be absorbed than an immune anti‐A2 of the same titre. The antigen recognized by this antibody seems to be covered by the same molecule as HLA‐A2, according to redistribution experime

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00563.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In 19 families with 97 children the segregation of Rga(Rodgers) was found to be compatible with Mendelian inheritance and five backcross and 14 intercross families were found among HLA and Bf typed families. Close linkage (lods + 17.82) without recombination was found between Rg and the HLA region, with a direct count of 96 nonrecombinant meioses forRg‐HLA‐B. Kg‐was strongly associated with HLA‐B8 (29 of 30 haplotypes) and probably associated with Bw40, but did occur on other HLA‐B haplotypes. By inference.Rg‐is negatively associated with Ch‐(Chido). The Rg‐Ch‐haplotype has not been observed. Rg3and Chamay or may not be coded for by different sites of the same cistron closely linked to HLA‐B:C and cannot as yet be excluded from be

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00564.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1976.tb00565.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY