摘要:

The bovine lymphocyte antigen system (BoLA) was studied by serological methods. Evidence for the existence of one locus was established and six codominant alleles were found to segregate at this first locus. The frequency varied considerably among these genes, and the presence of a null allele suggests that new BoLA specificities are likely to be found in the cattle population.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00803.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The anomalous false‐positive results often found in the primed lymphocyte typing (PLT) test seem to be partially due to the release of blastogenic factor (BF) from the stimulating cell, resulting in back stimulation of the primed lymphocyte. These anomalous responses can be greatly reduced by treating the stimulator cell with high doses of irradiation or with puromyci

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00804.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The HLA‐Bw4 and Bw6 antigenic determinants have been shown to co‐migrate with HLA‐B determinants on gel‐filtration, sucrose density gradient centrifugation and affinity chromatography, usingLens culinarislectin and antibody against human β2microbulin. These and other published data imply that the HLA‐Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA‐B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA‐B locus

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00805.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

One‐hundred‐and‐forty‐seven patients with autoimmune thyroiditis were studied with respect to HLA antigens as they related to various clinical features. HLA‐B8 was found to be significantly increased among 59 patients with atrophic thyroiditis (57% vs. 26% for controls) but was identical to controls in 88 patients with goitrous thyroiditis (26%). No relation was found in either group between B8 and thyroid autoantibody titer or, in the case of goitrous thyroiditis, the rate of progression of the disease. Thus a link seems to be established between Graves' disease and atrophic thyroiditis in that both are significantly associated with HLA‐B8. This study stresses the need to take clinical features into consideration when examining for HLA/disease a

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00806.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00807.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Previous studies of multiple sclerosis patients showed the existence of a positive association between multiple sclerosis and HLA—A3 and —B7, as well as a negative association with B12. These observations have been confirmed. In addition, a more marked association has been observed with two recently identified B‐cell antigens, DRw2 and DRw3, closely related to the HLA‐D locus. The presence of cold lymphocytotoxic antibodies was found to bear no relationship with those two specificities. These results suggest that two genes of the HLA—DR region may play a role in the pathogenesis of multiple

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00808.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The HLA profiles of three common populations from South East Asia, Chinese and Malays from Singapore and Filipinos from the Philippines are documented.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00809.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00810.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00811.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00812.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY