摘要:

The genetics of the MLR of the dog are studied using LD typing cells. The four new homozygous reference cells described bring the total number of defined LD specificities in this species to 11. In families, LD specificities generally segregate en bloc with the SD specificities of the DLA complex. The recombination frequency between the SD and LD loci is provisionally estimated to be 0.007. A slight but significant stimulation between two SD identical LD typed siblings could not be explained on the basis of a single recombination between the SD loci and one LD locus and therefore suggested the existence of an additional LD system.Unrelated SD different individuals with two different LD determinants in common frequently stimulate each other in MLR, but low responses are also encountered. The results described are compatible with a hypothesis of two segregant series of alleles for the genetic control of the MLR and linkage disequilibrium between certain alleles of these series. More conclusive evidence of the validity of this hypothesis and further knowledge of other factors which determine the response in the MLR are required before a reliable estimate of the importance of LD structures in histocompatibility can be made.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01106.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Anti‐human T‐lymphocyte serum (anti‐HTLA) was used to investigate the relationship between differentiation antigens of human (HTLA) andMacacalymphocytes. The percentage of lymphocytes sensitive to anti‐HTLA is the same in both species, with thymocytes having a higher concentration of HTLA than more mature T‐lymphocytes.Macacabone marrow cells acquire pheno‐typic properties of T‐lymphocytesin vitroin the presence of calf thymic factors. Our data suggest that phylogenetic distinctions between various T‐lymphocyte differentiation antigens may be utilized to provide antisera of nar

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01107.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Expression of the antigen HLA‐B12 on platelets, on lymphocytes and in serum of normal subjects was studied using several quantitative techniques. HLA‐B12 was found to be expressed on platelets from each of 25 heterozygous HLA‐B12‐positive donors in amounts varying about 35‐fold from weakest to strongest. Expression of B12 on platelets was enhanced in the presence of the first locus antigen A11, but decreased in the presence of A2, A3, and Aw28. The antigen was expressed in equal strength on lymphocytes sampled from the same donor population. Serum content of B12 assayed in five subjects was found to be roughly proportional to the expression of that antigen on platelets. Expression of B12 on platelets is under genetic control but the precise mechanism of inheritance has not yet been defined. The applicability of these findings to transfusion of single donor platelets to alloimmunized patients is under inve

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01108.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

A patient with severe aplastic anemia rejected consecutive bone marrow transplants from two HLA‐identical sibling donors. Following rejection, the patient developed antibodies that reacted strongly against donor lymphocytes in the complement‐dependent cytotoxicity assay. Whereas the reactivity was initially directed specifically against the first marrow donor, cells of both donors and most unrelated individuals were killed by sera obtained after the second rejection. These sera were also cytotoxic to the patient's own pre‐transplant cells but not to her autologous post‐transplant lymp

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01109.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

HLA genetic structure of the population in the district of Olomouc was studied through a sample of 267 healthy and unrelated individuals. Allele frequencies, haplotype frequencies and deltas are presented.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01110.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01111.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01112.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01113.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY