摘要:

For purposes of genetic comparison, the available HLA data on United States and African Black, together with United States Caucasoid populations, are summarized. Antigen frequencies and pairwise linkage disequilibria are presented for the HLA‐A, ‐B and ‐C loci in Black populations typed for the 1975 Histocompatibility Testing Workshop. The Black population samples comprise 356 North American Blacks and 411 African Blacks of whom 222 were Bantu. These are compared with a sample of 503 American Caucasoids. All significant linkage disequilibria between the A and B loci found in North American Blacks were also present in the North American Caucasoids. Between the B and C loci, Bw35 and Cw4 were in strong linkage disequilibrium in all groups. Significantly strong association between the A and C loci (Aw28 with Cw3) were observed only in the African Blacks. There were unique disequilibria both in the American Caucasoids and African Blacks. Although the frequencies of many antigens in U.S. Blacks lie between those in Africans and U.S. Caucasoids, there are exceptions such as Aw33, Bw35

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01095.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Genes controlling resistance of irradiated mice to allogeneic hemopoietic cells were mapped within, or closely linked to theDregion of MHC and were designatedHemopoietic‐histocompatibilitygenes (Hha).Hhpgenes responsible for resistance to parental hemopoietic cells had also previously been detected on theD‐end of MHC.Hhgenes are regarded as determinants of cell surface antigens (Hhantigens) phenotypically expressed, in contrast toHistocompatibilityantigens (Hantigens), only on blood‐forming and leukemic cells. The inheritance ofHhgenes is not codominant, unlike that ofHgenes, suggesting that theHhgenes andHgenes are independent entities.Hhantigens also seem to exist on rat and dog cells and it is plausible that these antigens also exist in man, and could influence the outcome of clinical bone marrow transplant

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01096.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Five antisera raised within HLA‐A and ‐B compatible, HLA‐D disparate combinations were reactive in a modified NIH microcytotoxicity test with B lymphocytes, but not with T lymphocytes from the immunizing donor, as well as with B lymphocytes from most or all donors sharing his immunizing HLA‐D phenotype. Four antisera recognized structures closely associated with the HLA‐D determinants Dw2, Dw3, Dw4 and LD 108. One serum had a broad reactivity pattern including Dw3, Dw6 and some unknown specificity(ies). In population and family studies, these B lymphocyte antigens behaved as if they were governed by one genetic locus in the B‐D region of the HLA complex. We conclude that the antisera produced by this method recognize Ia‐like antigens identical to or very closely associated with the HLA

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01097.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01098.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Xeroderma pigmentosum is an autosomal recessive disease. HLA‐A and ‐B typing was performed on peripheral blood lymphocytes and platelets. Sixteen Tunisian families were typed with 37 patients and 108 relatives. Genetic transmission of the disease and of the HLA system seemed to be independent in this study. Comparison of HLA gene frequencies between (unrelated) parents of patients and a control population showed no difference, proving that there is no clear association in populations between deleterious XP genes and a particular HLA gene. However, an excess of identical HLA among pairs of diseased siblings would suggest that the disease is polymorphic and a form of the XP could be linked to

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01099.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01100.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01101.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01102.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01103.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01104.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY