摘要:

We describe a serum, 9045, that detects a subset of A28 bearing cells in a mixed population of American blacks, Caucasians of Jewish ancestry and non‐Jewish Caucasians. The serum reacts preferentially with A28 positive cells from American Blacks and Jewish Caucasians and does not react with non‐Jewish Caucasians. This new specificity, referred to as A28.2, is strongly associated with HLA‐B14. In contrast, A28 positive but 9045 negative cells (referred to as A28.1) do not show this association. The A28.2 determinants appears to be antigenically similar to the A28.1 determinant, but distinct from the public antigenic determinants shared by A28, A2, A9 and by A28, Aw33, Aw34 and A26. Based upon this analysis, we conclude that HLA—A28, as defined by most A28 antisera, comprises at least two populations of molecules. The A28.2 form may have arisen in the Mediterranean basin region, whereas the A28.1 form seems to be more prevalent in non‐Jewish Caucasians of Northern European

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01435.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

One hundred fifty‐five healthy nonagenarians, 55 men and 100 women, all French Caucasians, were phenotyped for alleles of the A, B, C, DR loci of the HLA complex. The observed HLA antigen frequencies were compared to those of a control series of 133 males and 179 females whose ages ranged from 10 to 50 years. When comparing the total young and elderly series, no significant differences were observed with respect to HLA antigen distribution or heterozygosity at any of the loci. When taking sex difference into account, however, an excess of the Cw1 antigen was found in the group of elderly females (p<0.001) and an excess of the Cw7 antigen in the group of elderly males (p<0.001). Of particular significance was the fact that Cw7 belonged in this instance to a phenotypic combination (and most probably to the corresponding haplotype) A1/Cw7/B8/DR3 which was found significantly increased in male nonagenarians (p<0.001). These results support the hypothesis that certain HLA haplotypes are associated with survival advantag

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01436.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Immunoglobulin A (IgA) deficiency (<0.01 mg/ml) was demonstrated in 155 of 72,296 blood donors. Studies of families of 60 donors revealed IgA deficiency in other members of 12 families. No consistent pattern of inheritance of IgA deficiency was found. HLA typing of 62 unrelated IgA deficient blood donors showed a significant increase in the prevalence of HLA‐B8 (p<0.005

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01437.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

By means of a sensitive radioimmune anti‐IgG test (RIAT) HLA‐B7 was demonstrated on RBC ofallB7 positive individuals (N = 52). Most antigens of the B7 cross‐reacting group (B8, 13, w22, 27, 40; N = 36) were also detected. Eluates from B7 positive RBC exhibited clear B7 specificity against RBC as well as lympho

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01438.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The association of A3, B7, Dw2 and DR2 histocompatibility (HLA) markers with multiple sclerosis (MS) is well established among Northern Europeans and Caucasoids in the United States. We showed previously that A3 and B7 were not increased among Israelis with MS, and in a preliminary study Dw2 as well. An association of A3 and B7 is also lacking in Italian, Jordanian and Japanese MS patients. In Black American MS patients, the B7 frequency is slightly increased but Dw2 is still significantly associated with MS.For the HLA‐DR antigen series DR2 is shown to have a stronger association to MS than A3 and B7. Conceivably, this antigen could be associated with MS even in populations where an association with A3 or B7 is lacking. Therefore, a study of HLA‐A, B, C, DR and D antigens was carried out in Israel. No significant excess or deficiency of HLA antigens was found in MS.Possible explanations for these results are as follows: (1) the relevant HLA‐D alleles in the Jewish population arc not detected by the homozygous typing cells (HTCs) used, since they were derived primarily from European sources; (2) in contrast to the Caucasoid populations the genetic factor predisposing for MS is not associated with HLA alleles in the Israeli population; (3) MS is an heterogeneous disease and in Israelis, an environmental factor is sufficient to cause the di

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01439.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Nine lots of normal human immunoglobulin produeed in Bulgaria and India, prepared from venous or placcntal blood, were assayed for the presence of HLA antigens by the inhibition of cytotoxicity of HLA alloantisera using two different absorption procedures.The results indicate that the normal human immunoglobulin preparations tested here contain soluble HLA antigens as demonstrated by the inhibition of HLA alloantisera. Most of the higher frequency antigens of the HLA‐A, B, C and DR locus appear to be present in the Ig‐preparations. In samples from India there‐ appears to be a lack of HLA‐A3 antigen, which corresponds to the low frequency of A3 in this population. Immunoglobulins produced from different raw materials contain different amounts of soluble HLA a

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01440.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABO blood group compatibility is generally required for successful human kidney transplants and new data suggest donor‐recipient incompatibility for the Lewis or multiple minor blood groups is detrimental. This is of special importance in the setting of liberal transfusions prior to transplant. To assess the impact of immunizing exposure to disparate blood groups of ABO‐matchcd transfusions and kidney transplants, we studied the interrelationships of anti‐erythroeyte antibodies, leukocytotoxins and graft survival in 42 kidney transplant recipients. Three hundred forty‐four sera were screened for anti‐erythrocyte antibodies using standard hemagglutination techniques and for leukocytotoxins, using the antiglobulin method. Statistical analysis by computer used a 2 × 2 × 2 contingency table with model fitting. Only 13 of 42 patients had anti‐erythrocyte antibodies at some time: anti‐I (4); anti‐Kell (1); cold panagglutinin (7); unidentifiable agglutinin (1). Of 42 patients, 16 had no detectable leukocytotoxins. By computer analysis, immunizations to blood group and HLA antigens were independent phenomena. Analysis showed that leukocytotoxins, but not anti‐erythrocyte antibodies, were associated with poor graft survival. A computer generated probability of graft survival by antibody status is presented. We conclude that immunization to blood group antigens is not common, is largely non‐specific, and is not detrimental to

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01441.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The inclusion of HLA data in genetic studies of insulin‐dependent diabetes mellitus (IDDM) has not led to conclusive segregation models for IDDM so far. As a new approach, we first applied complex segregation analysis, independently of HLA data, to two combined Danish family materials. Then the best fitting segregation model was entered into linkage analysis of a third material, including family as well as HLA data. The best solution obtained in the segregation analysis was a mixed model, including an intermediate gene, which on the penetrance scale acts as a recessive, together with a polygcnic component. The linkage analysis showed an overall recombination fraction of 0.0417 with high coupling frequencies for theHLA‐DR3andHLA‐DR4alleles and the putative disease susceptibility gene. However, when the pedigrees were divided according to whether or not the proband had the heterozygous HLA‐phenotype DR3/DR4, a maximum likelihood ratio test for heterogeneity was significant, with estimated recombination fractions of 0.0 and 0.0963 in HLA‐DR3/DR4 pedigrees and the remaining pedigrees, respectively. In total, we found convincing evidence that two familial factors contribute to IDDM: a locus within HLA, which very well may be DR; and an unlinked mechanism which is unimportant for HLA‐DR3/DR4 but simulates recombination. If confirmed, this conclusion has important implications for further genetic studies of IDDM and complex segregation analyses of family materials sampled according to criteria which include HLA data of the probands are hi

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01442.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Human B blast specific target determinants, sclctivcly identified on PWM stimulated purified B lymphoblasts byin vitrogenerated CTLs, have previously been studied in the population and showedassociationto andinclusionof HLA‐DR geneproducts. This report indicates that B blast specific target determinants are products of genes which in a codominant mcndclain waysegregatewith the HLA haplotypes in 4 selected families. Furthermore tests of families withHLA‐B/D, DRandHLA‐D, DR/GLOrecombinations show that human B blast specific target determinants are coded from loci (locus) in theHLA‐D region, between HLA‐

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01443.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1982.tb01444.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY