摘要:

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive disease of the central nervous system. Its possible association with poliomyelitis was studied by measuring neutralizing antibodies against polio virus types 1, 2 and 3 in the sera and cerebrospinal fluids of 11 ALS‐patients, but antibody titers did not markedly differ from those of the controls. The HLA antigens of 12 ALS patients were also determined, in order to reveal any possible genetically‐determined susceptibility to the disease. Possible association of ALS with HLA‐Bw40 was noted. In addition, the Bw40 antigen seemed to be associated with milder progression of the disease. The lymphocytes of the ALS patients seemed defective in their capacity to stimulate allogenic lymphocytes, possibly due to a relative decrease of B cells in the peripheral blood. Joint efforts of study groups of neuroepidemiology, immunology and genetics should be mobilized to reveal the true nature of these fin

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00755.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Both F(ab′)2fragments and intact antibody from rabbit anti‐B‐cell antisera were shown to specifically block the mixed lymphocyte culture (MLC) reaction. The antisera, which were raised to papain‐solubilized spleen cell membrane antigens, appeared to block the stimulator cell and not the responder cell. Specificity of the blocking was shown in that antisera to beta2micro‐globulin would not block the MLC‐stimulating cell. Membrane antigens from acute lymphocytic leukemia cells were labeled with125I, solubilized with sodium deoxycholate and immuno‐precipitated with either human or rabbit anti‐B‐cell antisera. Both sources of antisera precipitated polypeptide subunits of 27,000 a

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00756.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Forty‐four cases of insulin‐dependent diabetes mellitus with cutaneous allergic reactions to insulin were typed for HLA‐A and ‐B antigens. HLA‐B7, which commonly is negatively associated with insulin‐dependent diabetes mellitus, showed a positive association with insulin allergy. A second antigen, HLA‐Bw21 may also be positively associated with local insulin allergy. These data were discussed in relation to heterogeneity of insulin‐dependent diabetes mellitus and to the existence of B7‐associated immune response genes for allergic immunoreac

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00757.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Healthy individuals' peripheral blood lymphocytes show wide ranges of response to mitogens and allogeneic lymphocytes. When individuals' lymphocytes are pooled together, the responses of the pool are equivalent to the means of the responses of the lymphocytes which comprise the pool. Pooled lymphocytes retain their responsiveness when stored frozen, and may be used as standard responding cells in lymphocyte transformation tests, but are not suitable controls for antigen‐induced lymphocyte transformatio

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00758.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Thirty‐three patients with Cystic Fibrosis were HLA typed. Relative risk values and phenotype frequencies were calculated. No statistically significant differences in the HLA antigen distribution were found among the patients with Cystic Fibrosi

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00759.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The distribution of 24 HLA antigens of the A and B loci was investigated in 197 Israeli Jewish patients with multiple sclerosis (MS) from various Jewish ethnic origins including central and eastern Europe, countries bordering the Mediterranean, the Middle East and from native‐born Israelis. The results were compared with the HLA antigen frequencies in a control sample of 455 unrelated individuals representing the general Jewish population.The frequency of HLA—Bw40 among all MS patients (15%) was significantly greater (P<0.001) than among the controls (7%). In contrast to the findings in MS patients from other populations, there was no increased frequency of A3 and B7 and Dw2 was present in only one out of 28 patients. The study showed a similar distribution of HLA‐A and ‐B locus antigens, especially of Bw40, in Jews of diverse ethnic origins represented in the contro

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00760.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The frequencies of HLA‐A and ‐B locus antigens in a group of 64 individuals from Iraq are reported. The frequencies are in broad agreement with those previously reported for Arabs, but show differences from Persian frequenc

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00761.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Macrophages were obtained from human peripheral blood by incubating mononuclear cells in plastic tissue culture flasks. After 1—14 days, the cells were used in mixed lymphocyte macrophage cultures. Macrophages could not, themselves, be stimulated to proliferation by allogenic cells, but stimulated allogenic lymphocytes. By the use of responding cells and stimulating macrophages from HLA‐D homozygous individuals, the HLA‐D determinants could be shown to be responsible for the stimulation of allogenic lympho

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00762.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Contrary to previous reports, we have obtained no evidence that 4a and 4b antisera specifically inhibit C3 rosette formation by human lymphocytes. Pretreatment of lymphocytes with various whole 4a and 4b antisera resulted in partial inhibition which was often nonspecific. Ultracentrifugation of the sera to remove immune complexes removed C3 rosette inhibitory activity although specific cytotoxic activity remained. It is probable that immune complexes in antisera will have fixed C3 which will have been converted to C3d and so be able to block the C3d receptor. This is the receptor mainly measured in these and in the previous experiments.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00763.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Of 28 unabsorbed sera from polytransfused individuals or multiparous women, which were not cytotoxic for total peripheral blood lymphocytes, 13 were found to react positively against B cell‐enriched suspensions. These 13 sera were further characterized after platelet absorption‐elution, as well as by pretreatment with turkey anti‐human‐β2‐microglobulin serum. Different patterns were found: five sera behaved as pure anti‐B cell reagents; four seemed to contain different antibody populations, directed against both B cell determinants and HLA‐A, ‐B or ‐C antigens; four only contained antibodies directed against HLA‐A, ‐B or ‐C specificities. Absorption experiments with purified T and B lymphocytes, showed that these last sera, although non‐cytotoxic for T cells, can be absorbed by them. It was concluded that not all sera reacting only with B lymphocytes recognize specificities absent from T cells, and that all sera should be exhaustively absorbed with platelets before being tested as ant

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00764.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY