摘要:

The analysis of the antigenic structure of murine spermatozoa has been hampered by the lack of a convenient objective serological assay. Spermatozoa, in common with other cells, are capable of concentrating86rubidium. Antibody mediated complement dependent cytotoxicity of murine spermatozoa has been quantitated by measuring release of86rubidium from pre‐labeled spermatozoa. We have used this assay to study the murineT/tlocu

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00781.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

HLA—A and —B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. There were no statistically significant deviations from expected antigen distribution in patients with any of the various forms of leprosy, though the number of patients studied is relatively small. There were some interesting trends, particularly a possible decrease in the number of tuberculoid patients with A9, and an increase in the proportions of lepromatous patients with B18 and B40.Limited evidence of a genetically controlled pre‐disposition to the clinical manifestations of leprosy suggests that further studies with extended typing should be carried out on the HLA haplotype segregation in informative leprosy families. These should provide a clearer indication of the relevance of the HLA (including DR) and possibly of other non‐HLA loci to the possible mechanism (s) of disease suscept

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00782.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Plaque‐forming cells can be generated from peripheral blood lymphocytes provided that the lymphocytes are prestimulated byin vitrosensitization in the presence of pokeweed mitogen. Of 91 blood type O persons whose lymphocytes were stimulated with red cell A antigen, 52% responded with plaque formation, whereas of 40 type O persons whose lymphocytes were stimulated with red cell B antigen, only 20% produced plaques. Similarly, reciprocal stimulation of type A and B persons showed higher plaque formation (65%) when 23 type B persons were stimulated with A than when 48 type A persons were stimulated with B red cells (19%). An optimal dilution of sensitizing cells is necessary and maximum time of sensitization was approximately 7 day

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00783.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

When studying the specificity of human lymphocytes primedin vitroagainst HLA—D determinants on allogeneic cells, it was found that specific restimulation of the primed cells 10 days after the first priming did not influence their discriminatory power compared to cells primed only once. Likewise, priming to one HLA—D determinant and repeated priming against another HLA—D determinant did not change the discrimination for the first priming antigen. Neither was there any increased relative reactivity to the second priming determinant. On simultaneous priming against two HLA—D determinants carried by two different stimulating cells, a good discrimination for both antigens was obtained compared to third party cells, but if the stimulations were separated by 24 h or more, the second priming was mainly without effect. Antigeneic competition is thought to be the mechanism involved in this early restriction of spec

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00784.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00785.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A technique is described for enriching, from human blood, cells bearing HLA—DR antigens. The method depends on the use of monoclonal mouse antibody which reacts with HLA—DR structures. Cells to which this antibody has bound can be separated after resetting with bovine erythro‐cytes coated with anti‐mouse immunoglobulin. The cells thus enriched may be used for HLA—DR typing by standard cytotoxicity methods with alloge

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00786.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Investigations of HLA and blood‐groups were carried out in 68 patients with infectious mono‐nucleosis comprising all known cases diagnosed within one year in a restricted geographical area of Denmark. The HLA distribution of these patients did not differ significantly from that of controls. Combining the results of the present investigation with two previous studies did not show any significantly different distribution from that of combined control groups. The ABO and Rhesus typing was in accordance with that found in a major Danish control group. However, available studies do not exclude the possibility that HLA‐D/DR or still unknown HLA factors may be involved in the susceptibility to mononucl

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00787.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Previous studies of HLA antigen frequencies in asbestos related pulmonary fibrosis have suggested some weak associations both with susceptibility to the disease (B12 and B27) and protection from the disease (B18 and Bw35). HLA typing was performed on a further series of 64 asbestos workers with no chest abnormality and 166 workers with various radiographic changes, 78 having pulmonary fibrosis. The results fail to give statistical confirmation of these associations although B27 was twice as frequently associated with pulmonary fibrosis and diffuse pleural thickening. Analysis of the combined data from this and four other studies failed to show any consistent associations.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00788.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Despite the strict criteria required to distinguish Multiple Myeloma (M.M.) or Waldström's Macroglobulinemia (W.M.) from Benign Monoclonal Gammapathy (B.M.G.), nosological frontiers are still unclear and accordingly justify a comparative serological study of M.M., W.M., and B.M.G. patients

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00789.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00790.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY