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1. |
The RhLA Complex of Rhesus Monkeys. XI: Positive MLC Reactions between Identical Sibs Caused by Alloimmunization1 |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 239-254
A. A. Es,
H. Balner,
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摘要:
D‐locus identical pairs of monkeys were alloimmunized. An exchange of skin and blood between initially MLC‐negative unrelated monkeys frequently led to strong mutual reactivity in mixed cultures. This was not the case when RhLA identical siblings were similarly (mutually) immunized. These data led to the postulation of a second RhLA‐linked MLC locus, named D', which exerts its influence only after alloimmunization. Interestingly, strong MLC responsiveness between the RhLA identical siblings could be provoked after further immunization with tissue from a third party animal. This unexpected MLC‐reactivity is ascribed to the influence of minor non MHC linked loci which express themselves if the responder has been sensitized against a disparate D'‐product. It is suggested that the postulated D' locus has a “helper function” in that it assists in triggering proliferative responses in mixed cultures against the products of these
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00793.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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2. |
The Major Histocompatibility Complex of Rhesus Monkeys XII: Cellular Typing for D Locus Antigens in Families1 |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 255-272
A. A. Es,
H. Balner,
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PDF (1056KB)
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摘要:
Typing cells (TC) were used for the identification of D locus antigens in rhesus monkey families. The antigens defined by this cellular method always segregated with the other RhLA‐controlled markers except in one offspring with a proven recombination within the RhLA region; in that case, the D antigen was inherited in coupling with an antigen of the Ia1locus (the analog of the human DR locus). With two exceptions, each TC or group of TC's was associated with one of the serologically defined Ia1antigens. The two exceptions were associated with “blanks” of that series. Interestingly, two independent (mutually MLC responsive) TC groups appeared to be associated with the same Ia1antigen 75*. Equally noteworthy was the observed “inclusion phenomenon” among cells of several TC groups, each associated with a single Ia1antigen or blank of that series. In these cases, some of the TC's of the group were unidirectionally MLC‐responsive against other cells of the same group. Certain pitfalls of cellular typing are discussed; unexpected “false positive” results were attributed to prior immunization with products of non‐D loci which have been described recently (van
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00794.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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3. |
Lack of Linkage between Acute Intermittent Porphyria and the A and B Loci of the HLA System |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 273-277
M. M. Tongio,
S. Mayer,
G. Hauptmann,
M. L. North,
C. Koehl,
J. Abecassis,
P. Mandel,
J. Wertenschlag,
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PDF (216KB)
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摘要:
Forty‐six members of a family known to have Porphyria were studied. As the disease is often latent clinically, erythrocyte uroporphyrinogen I synthetase activity was determined to classify the subjects as being healthy or carriers. HLA—A, B, C, Bf, GLO antigens were determined. No linkage between acute intermittent Porphyria and the HLA system was noted in this fam
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00795.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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4. |
Different Stimulating Capacity of Monocytes and B Lymphocytes in Mixed Leukocyte Cultures: A Dose Response Study |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 278-289
J. C. Gluckman,
P. Degoulet,
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PDF (594KB)
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摘要:
Cell fractions highly enriched either for monocytes or for B lymphocytes were separated from human peripheral blood. They were tested for their capacity to stimulate allogeneic lymphocytes in mixed leukocyte cultures, using dose‐response titrations. Neither population could be stimulated to proliferate by allogeneic cells, but both proved strong stimulators. In this respect monocytes were more efficient than B cell preparations. Differences were pronounced at the lower numbers of stimulating cells but were no longer significant with large amounts of cell
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00796.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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5. |
B Cell Antigens of Black Americans |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 290-297
F. E. Ward,
D. B. Amos,
D. Jongh,
A. H. Johnson,
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PDF (434KB)
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摘要:
Forty‐four unrelated North American Blacks and one Black family were tested for B‐cell specific antigens with 7th International Workshop antisera. DR specificities were clearly defined in this group, but were generally less frequent than those reported for Black Americans in the 7th Workshop report and were most similar in frequency to those reported for African Blacks. Five new B‐cell specificities (DuB40–43, 45) were identified. In contradistinction to Caucasians, Black Americans typed for HLA—D with homozygous typing cells failed to exhibit strong linkage disequilibrium between D and
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00797.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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6. |
Cross‐Reactions of HLA Antibodies: VII. Rate of Sensitization and Serological Specificity |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 298-306
Donna D. Kostyu,
Nicole F. Bernard,
D. Bernard Amos,
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PDF (459KB)
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摘要:
Varying the sensitization time of the complement‐dependent antibody mediated cytotoxicity test, while carefully controlling other test conditions, has enabled us to characterize the subtle reactivities of several broadly reactive sera. In particular, we can discriminate between classes of cells, e.g., HLA‐B7 from B27; subclasses of cells, e.g., Bw51 from Bw52; and cells carrying new antigens, e.g., Ao79.This manipulation of the cytotoxicity test is discussed in view of its usefulness in separating primary from cross‐reactive specificities and in detecting new specific
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00798.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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7. |
HLA Compatibility in Couples with Children Suffering from Acute Leukemia or Aplastic Anemia |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 307-309
Ch. Werner‐Favre,
M. Jeannet,
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摘要:
The frequency of common HLA‐A and ‐B antigens was determined in 30 couples having a child with acute leukemia (AL), 34 couples having a child with aplastic anemia (AA) and 58 random couples with healthy children. An increased frequency of couples sharing at least two common antigens was observed in parents of both AL and AA child
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00799.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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8. |
HLA—A, —B, and —D Antigens in Paralytic Poliomyelitis |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 310-313
Helmut Zander,
Hans Grosse‐Wilde,
Barbara Kuntz,
Siegfried Scholz,
Ekkehard D. Albert,
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PDF (202KB)
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摘要:
Sixty‐two unrelated Caucasian patients from the Munich area who had had paralytic poliomyelitis in the 1950s and the early 1960s were analyzed. HLA—A and —B typing was performed for 26 antigens. HLA—D typing was done using six different established homozygous typing cells defining the specificities Dw1‐Dw5 and Dw11, plus one locally defined typing cell. None of the HLA—A, —B or —D determinants showed a significant deviation in frequency from control populations. Of interest may be a decrease of B8 and an increase of Bw16 (Bw38/39) and B27, but these deviations are not significant if theirPvalues are corrected for the number of c
ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00800.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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9. |
HLA—A and —B Antigens and the Human Fetus |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 314-316
R. W. Doughty,
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PDF (159KB)
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ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00801.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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10. |
HLA in Multiple Endocrine Adenomatosis (Type I) |
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Tissue Antigens,
Volume 13,
Issue 4,
1979,
Page 317-318
R. T. Jung,
V. C. Joysey,
M. Davie,
T. M. Chalmers,
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PDF (85KB)
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ISSN:0001-2815
DOI:10.1111/j.1399-0039.1979.tb00802.x
出版商:Blackwell Publishing Ltd
年代:1979
数据来源: WILEY
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