摘要:

The frequencies of the HLA antigens were determined in a population of 160 unrelated Cubans from three different ethnic groups (white, mixed‐blood and negro). We typed for antigenic specificities of the A and B loci, and also for the Cw1 specificity of the C locus. Phenotype and gene frequencies for the different ethnic groups are presented for comparison. The phenotype distribution, the haplotype frequencies for the white group and the genetic distance between this group and a Spanish population were calculate

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01085.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

To study the role of genetically determined immune responsiveness in the pathogenesis of systemic amyloidosis complicating rheumatoid arthritis the HLA antigens were identified in 26 patients with rheumatoid arthritis complicated by secondary amyloidosis, in 44 patients with rheumatoid arthritis, and in 11 patients with secondary amyloidosis of non‐rheumatoid origin. Subjects with ankylosing spondylitis, sacroiliitis without peripheral polyarthritis, Reiter's disease, reactive arthritis, erosive osteoarthritis, psoriatic arthropathy, systemic lupus erythematosus or arthritis associated with a gastrointestinal involvement were excluded from the study. Patients with amyloidosis secondary to rheumatoid arthritis had a high frequency of the HLA specificity B27 and of the haplotype likely to bear A2, B27. The association with B27 was closest in the group of male patients with amyloidosis whose rheumatoid arthritis had begun at an early age and who lacked demonstrable rheumatoid factor in serum. These patients may represent a genetically determined subentity of rheumatoid arthriti

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01086.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The HLA haplotypes were defined in a series including 11 patients with hereditary angioneurotic edema (HANE), five symptom‐free subjects with pathological laboratory findings characteristic of HANE, and their 33 healthy kinsmen. The subjects belonged to two Finnish families representing the more common form of HANE which is recognized by the immunochemically observed decrease of the inhibitor (C1‐INH) blocking the esterase activity of the first complement component. No linkage between HANE and the HLA system was fo

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01087.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The cellular composition of rat popliteal lymph nodes undergoing a GVH reaction was examined. The great majority of cells isolated from the nodes were lymphocytes, while the contribution of phagocytic cells was negligible (<5%). Both T and B cells were present in GVH nodes. However, the proportion of B cells was higher than in normal lymph nodes (40–50% vs 30%).Cells synthesizing DNA were enumerated autoradiographically in sections of GVH nodes up to day 7 of the response. A significant increase in the proportion of 3H thymidine labelled cells had already been found on the third day of the GVH response, before lymph node enlargement was apparent. Of the differnt days tested a maximum of 6% labelled cells was found on day 7. Liquid scintillation counting of cell suspension from such nodes showed an even higher increase in 3H thymidine incorporation in GVH vs normal nodes. These findings indicate that cell proliferation is a central mechanism behind the lymph node enlargemen

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01088.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The frequencies of HLA antigens and genes were determined in 491 unrelated individuals from the area of Madrid. In order to obtain a fairly good idea of the HLA antigen frequencies in the Spanish population, our results have been compared with those reported from Barcelona. Haplotype frequencies were observed in 212 parents and compared with the frequencies estimated from the 491 individuals. The present data show certain characteristics of the Spanish population and are in good agreement with other studies in the demonstration of linkage disequilibrium between genes of the two series.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01089.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The reactivity of anti‐HLA hyper‐immune sera was tested by the microlymphocytotoxicity technique (LCT) against a panel of mouse lymphocytes. Three levels of reactivity were observed: negative (immune sera titre 1: 20 or less), weak (titre 1: 40 to 1: 80 with a percentage of dead cells less than 50%) or strong (titre 1:60 or more with 100% killing). Thirteen normal human sera were non‐reactive. Eleven out of 60 hyper‐immune sera were strongly reactive. Tests using congenic lines showed that the reactivity was controlled at theH‐2complex. One serum (COD‐RON) was studied in detail. When tested against a panel of strains carrying 10 differentH‐2haplotypes, it reacted strongly against lymphocytesH‐2d, ja, k, pandr; and did not react, or at least only weakly, against lymphocytesH‐2b, f, q, sandv.Tests using mouse strains carrying the recombinantH‐2haplotypesh4, i5, i, y2, g, g2andt1, suggested that the observed reactivity was directed against structures controlled at theKend of theH‐2complex (H‐2.47?). Absorption‐elution experiments with human and murine lymphocytes and platelets confirmed that the structures recognised by serum CODRON were determined at the major h

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01090.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

An examination of 1009 backcross animals produced fromH‐2b/H‐2t1heterozygotes resulted in the detection of four cases of intra‐H‐2recombination. Three of the recombinants received theKregion fromH‐2band theDregion from theH‐2t1parental chromosome. The fourth recombinant received aKregion from theH‐2t1parental chromosome and theDregion fromH‐2b. Ss typing revealed that crossing over occurred between theSandDregions of theH‐2complex in all four cases. Three of the four recombinants were developed into inbred strains and assigned the haplotype designationsH

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01091.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01092.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01093.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb01094.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY