摘要:

The distribution of HLA phenotype, genotype and haplotype frequencies was studied in two Iranian populations, the Armenians and the Jews. Although the frequencies of most antigens in the Armenians have approximately the average Jewish values, haplotype frequencies are quite different between the two populations. The frequencies of antigens in Iranian Jews are more similar to those in the Mazandaranies, a group of non‐Jewish Iranians, than to the Jewish populations from Yemen and Cochin, Indi

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01338.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Conventional formulae currently employed were extended to calculate the haplotype frequency and the corresponding variance for an arbitrary number (n) of loci when unrelated individuals were investigated. A formula is presented for the variance for the degree of three locus linkage disequilibrium.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01339.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A Hungarian random population sample was tested for six well‐known and two new HLA—D specificities. HLA—D antigen and gene frequencies in the studied population agree with the frequencies observed in pooled random Caucasians, only HLA—Dw3 being significantly elevated. The incidences of Dw1 and Dw4 are, however, lower while the incidences of the Dw5 and Dw6 alleles seem to be higher in our population sample without reaching statistical significance. As for the two new specificities, the IVÁD‐1 specificity has a low frequency, while IVÁD‐3 occurs quite frequently.HLA–B and HLA—D associations seem to be different in our population sample as compared to others. In spite of the high incidence of the HLA—Bw35 antigen, no HLA‐D association was found. The two new HLA—D specificities did not show association with any of the est

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01340.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Heteroantibodies present in normal rabbit serum (NRS) are toxic to human B lymphocytes, T lymphocytes, and monocytes. Even NRS, which exhibits little back ground cytotoxicity for human lymphoid cells in conventional HLA or B‐cell lymphocytotoxic assays, can be shown to contain considerable activity by making two modifications in usual procedures: by washing cells in saline or balanced salt solutions devoid of protein or sugar substances, and by increasing incubation time from 1 h to 3–4h. Using such modifications, the cytotoxic activity of NRS towards human lymphoid cells was investigated and was found to involve activation of the classical complement pathway rather than activation of the alternate complement pathway. Residual unwanted background cytotoxicity of NRS toward human lymphoid cells can be decreased without loss of desired complement activity either by heating NRS for 15 min at 50° C or by mixing NRS with small amounts of normal human s

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01341.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The frequencies of 32 HLA antigens of the A and B series were determined in a previously unstudied population of Mexican‐Americans in South Texas. The phenotype and gene frequencies for this group are presented and are contrasted with those determined in studies of Mexican/Mexican—American populations from two different locales. The statistically significant differences observed emphasize the need for indigenous controls when evaluating racially heterogeneous populations for disease‐associated HLA ant

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01342.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The program GENEMAP, which performs the computations of a model for the mapping of a gene locus (Baur&Spitzer 1978), is applied to the localization of the phosphoglucomutase 3 with family data as published by Lamm et al. (1972), Rittner&Kalbheim (1975), Albert et al. (1977) and Kömpf et al. (1977). On the basis of Lamm's recombination fractions the combined odds were 13: 1 in favor of an orientation of PGM3to the HLA—B‐

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01343.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01344.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In three families with hereditary ataxia, where the inheritance pattern was autosomal and dominant, HLA antigens were determined in 25 members. In two of the families, HLA linkage of disease was suggested, whereas in the third family, the data did not directly support this concept, since two recombinational events between the postulated locus for disease and the HLA region had to be assumed. However, with this assumption, our data are compatible with those of one family described recently (Jackson et al. 1977) implying the presence on the sixth chromosome, outside the HLA region, of a locus that determines the development of spino cerebellar ataxia (SCA). Further tests with definition of enzyme markers will have to be performed before conclusions as to HLA linkage of a postulated SCA gene can be made.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01345.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The specificity of lymphocytes primed against allogeneic cellsin vitrohas been examined in order to find the optimal conditions for detection in the restimulating response of HLA—D specificity, as defined by homozygous cell typing. It was found that reducing the number of stimulating cells to less than the number of responding cells (ratio R/S = 4:1) in the priming culture, and increasing the number of stimulating cells at restimulation gave better discrimination. Priming with HLA—D heterozygous stimulating cells, where the responding and stimulating cells shared the other HLA—D determinant, rendered the primed cells somewhat more discriminatory than priming with HLA—D homozygous cells. The optimal length of the secondary culture was found to be abo

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01346.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Twenty‐eight patients with myasthenia gravis (MG), five with and 23 without thymoma, and 47 normal controls were typed for serologically defined HLA—A, B, C, and DRw antigens. Sera from all patients were titered for antibodies to acetylcholine receptors (AChR). The frequency of HLA—B8 and DRw3 in the non‐thymoma MG patients was significantly higher than in the normal population. Most of the non‐thymoma patients with AChR titers higher than the average level were positive for HLA—B8 and/or DRw3, while the majority of the HLA—B8 (—) and/or DRw3 (—) non‐thymoma patients demonstrated AChR titers below average.These findings support the possibility of the existence of immune response genes in the HLA—B, DRw segment of the major histocompatibility complex which are concerned in the response to or recogn

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01347.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY