摘要:

The frequencies of HLA locus A, B and C antigens were determined in a previously unstudied population, the Zoroastrians. The phenotype and gene frequencies for this group are presented and contrasted with the distribution of HLA antigens among the Iranian Moslems. Comparison of the HLA profiles of these two Iranian populations suggests that the present Zoroastrians are a distinct group.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00698.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A group of patients with cutaneous sensitivity was compared with another group with cement dermatitis who showed sensitivity to chromate. HLA typing for A and B locus antigens demonstrated a 29% incidence of B21 in the nickel sensitive group (control population 4.9%) and the antigen was not found in 16 patients with chromium sensitivity. It is suggested that this may represent a hapten specific HLA dependent immune response in man.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00699.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

We found HLA‐DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA‐A, B, C antigens were seen. In contrast HLA‐DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroi

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00700.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

By mixing HLA‐DR antisera of different specificities and testing them against B lymphocytes carrying the corresponding antigens, a synergistic action of HLA‐DR antibodies was revealed. Furthermore, it was demonstrated that HLA‐DR and HLA‐ABC antibodies may act synergistically against appropriate B cells. HLA‐DR homozygous B lymphocytes were found to react more strongly with HLA‐DR specific antisera than heterozygous cells, thus revealing a gene dose effect in HLA‐DR serology.ABO antibodies were found not to react against B lymphocytes, either alone nor in concert with HLA‐DR antisera. The practical implications of synergism and gene dose effect in HLA‐DR serol

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00701.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Thirty‐five wild mice (Mus musculus L.) were captured at four different localities in Chile. The mice were typed for the presence of 15 K‐, 11 D‐, 14 A‐, and two E‐region H‐2 antigens, using the complement‐antibody microcytotoxicity assay. The mice from the sample representing the largest locality had a characteristic antigenic profile distinguishing them from other mouse populations thus far studied. With respect to class I H‐2 antigens, the profile was characterized by the presence of antigens H‐2K.16, 31, 103, 19, 108, 21, 33, 26, 115, and H‐2D.4, 106, 30, 32, 111, 114, and 18 (in order of decreasing antigen frequency), and by the absence of antigens H‐2K.15, 17, 20, 113, 116 and H‐2D.2, 9, 110, and 112. The profile was, furthermore, characterized by the relatively high frequency of antigens H‐2K.16, 31, and H‐2D.4 and 106. The profile of class II antigens was also unique to the Chilean population but less conspicuously so than that of the class I antigens. Analysis of antigenic associations suggested that among the 34% blank H‐2K alleles there were at least two coding for relatively frequent but as yet unidentified K antigens. Similarly, among the 57%blanks at theH‐2Dlocus there were at least two frequent alleles encoding unidentified D antigens. Analysis of genetic distances suggested similarity between South American mice and mice

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00702.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

It has been of considerable interest to determine if the HLA associations with insulin‐dependent diabetes mellitus (IDDM) in blacks are the same as in whites in the United States. Seventy‐nine black IDDM patients who were under the age of 40 at onset and 283 black controls were HLA typed for A, B and C specificities. This is the largest sample of black IDDM patients yet reported. Analysis of HLA antigen frequencies for these samples has revealed an increased frequency of HLA B8 (p<0.01), B13 (p<0.02) and B15 (p<0.006), and a decreased frequency of B14 (p<0.01). The estimate of relative risks for B8 and B15 was 2.6 and 4.4, respectively. Comparison of a subsample of the black patients (n= 61) and controls (n=137) revealed increased frequencies of DR3 (p<0.0004), DR4 (p<0.0002), and DR7 (p<0.03) in the IDDM patients. Both HLA DR2 and DR5 were decreased in the diabetic patients (p<0.0()01 andp<0.0002, respectively). Allpvalues were uncorrected. The associations of HLA antigens with IDDM in our black American sample are essentially the same as those found in white IDDM patients. This suggests that the occurrence of IDDM in American blacks may be due to admixture of white ge

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00703.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The present study describes two new HLA‐D specificities: LD13, associated with DR1, and LD14 associated with DR2. LD13 is defined by an HTC who is thebcoffspring of ana: A25, B18, DR7, Dw7/b: A33, B14, DR1, Dx father, and of ac: A24, B14, DR1, Dx/d: A26, B41, DR5, Dw5 mother. This HTC was included both as a responder and as a stimulator in our cross‐reference studies of 8W HTCs. While failing to cluster with any other 8W HTC, it typed 2 of 64 panel members carrying a “blank” HLA‐D, linked to DR1. To exclude the possibility that HTC‐LD13 might be a split of Dw1, the entire family was tested with the Family Set of 8W HTCs. No typing responses to any 8W Dw1 HTCs were observed. Furthermore, checkerboard experiments between HTC‐LD 13 and 8W Dw1 HTCs showed strong reciprocal stimulation. The LD13 specificity was only found in Ashkenazi Jews and may be in linkage disequilibrium with HLA‐B14. LD14 is defined by three, SD different, HTCs deriving from the same family of Sicilian descent. The family was included in the 8th Workshop and each HTC was shown to have inherited DR2, MT1 from both parents. When tested as stimulators, on our HLA‐D reference panel, these cells were clustered in a distinct group, LD14, associated with DR2. None of the 8W HTCs appeared to belong to this cluster. The antigen frequenc

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00704.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A monoclonal antibody (AAP1) to human intestinal alkaline phosphatase (ALP) was produced by immunizing a mouse with D98/AH‐2 (HeLa) cells, which produce the enzyme ectopically. The antibody, which did not inhibit enzyme activity usingp‐nitrophenyl phosphate as the substrate, was of the IgG2A class and did not show complement‐dependent cytotoxicity. In trace binding assays AAP1 bound only to cells that expressed an intestinal‐like form of human ALP, including some human intraspecific (D98/AH‐2 × human lymphocyte or fibroblast) hybrids. Immuno‐precipitation of immune complexes from cell‐free extracts of D98/AH‐2 cells, using protein A containing 5.aureusand AAP1 antibody, resulted in precipitation of all the ALP activity. The precipitated material had a subunit molecular weight of 80,000 daltons, as estimated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate. In non‐denaturing conditions, AAP1 antibody prevented the migration of ALP activity into the gel when cell‐free extracts were made from human adult or fetal intestine, or D98/AH‐2 cells. Similarly, AAP1 could be used to precipitate ALP activity from these extracts but not from extracts of human liv

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00705.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The association between HLA and coeliac disease (CD) was studied in the Jewish population of Israel. A total of 112 patients were typed for HLA‐A,B,C antigens, including 67 patients whose families were typed in order to deduce the genotypes. Forty‐seven patients were typed for HLA‐DR antigens. The HLA‐A,B,C data show a pattern of association, which is similar to that found in European CD patients: HLA‐B8 is increased, although to a lower degree; a suggestive, insignificant increase for Aw30, B13 and Cw6 and a decrease of Bw35 were noted. The DR antigens DR3 and DR7 are associated with CD in the Jewish population. An excess of DR3/DR7 heterozygotes was noted. The data from family and population studies support a model in which twodifferentHLA‐DR associated genes are i

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00706.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

HLA‐A and‐B antigens were determined for 300 unrelated Mexican‐Americans and 300 unrelated Caucasians from San Antonio by the microlymphocytotoxicity technique, using lymphocytes isolated from freshly drawn peripheral blood. Haplotype frequencies for the Mexican American population were obtained directly, based on family studies, as well as estimated from phenotype data. The results revealed clear differences in the distribution of HLA antigens between Mexican American and Caucasian populations. The predominant HLA specificities in Mexican Americans were A2 and Bw35, while the most frequently observed haplotypes were A2‐Bw35, A2‐B12 and A2‐Bw40. Despite the distinct differences in HLA antigen distribution between Mexican American and Caucasian populations, genetic distance values, calculated from the HLA frequencies, were surpr

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1981.tb00707.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY