摘要:

A nomenclature committee composed of geneticists and immunologists, including specialists in tissue typing, has met after each of the Histocompatibility Testing workshops beginning with the 3rd Workshop in 1967. The committee met again, in part under the auspices of the World Health Organisation and to report to the International Union of Immunological Societies, after the 7th workshop in Oxford in September 1977, with the aim of updating the nomenclature for specificities of the HLA—A,—B,—C and—D loci and establishing a nomenclature for the new specificities identified by serological techniques on B lymp

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01231.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In primed lymphocyte typing (PLT), it will often be useful to divide the test cells for any given reagent into a positive and a negative group. Some general problems in PLT analysis are discussed here. The author describes a model for PLT data, to provide a conceptual framework, and suggests a statistical procedure based on the model.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01232.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The lymphoblastoid cell line Daudi lacks both HLA—A and B antigens and β2microglobulin. Somatic cell hybrids derived from a fusion between this line and D98/AH‐2 were shown to express four HLA antigens not detectable on either parent cell, A1, A10(Aw26), Bw16(Bw38, Bw17. The initial definition by direct cytotoxicity assay was confirmed by absorption of reactions against target T lymphocytes, thus avoiding problems due to contaminating Ia antibodies, and by blocking the reactions by pretreatment with a chicken anti‐human β2microglobulin serum. That the new specificities were due to the Daudi HLA region was confirmed by the finding that interspecific hybrids between Daudi and A9L, containing a single human chromosome 6, expressed A10 and Bw17. This also defined the haplotypes of Daudi asA10(Aw26), Bw17andA1, Bw16(Bw38).The re‐expression of the Daudi HLA—A and B antigens in two independent sets of hybrids indicates that it does not carry a mutation in the HLA region. It has previously been reported that somatic cell hybrids with Daudi, which contain chromosome 15, do not express human β2microglobulin. These results suggest that the reason for the lack of HLA—A and B antigens on Daudi is a secondary effect due to the mutation(s) in the β2mic

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01233.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The frequency of HLA‐B5 in 24 Israeli Behçet disease (BD) patients from various subpopulations was significantly greater than in 615 control individuals (P<0.003). The relative risk for a B5 carrier to develop BD was calculated to be 5.0. Six patients were offspring of consanguineous marriages, which is not unexpected in the populations studied. Five of the patients had only one HLA‐B antigen, which in four cases was B5. Two of the latter were B5 homozygotes, indicating a possible greater susceptibility. This study confirms the reported association between BD and HLA‐B5 in a population not previously investigated. Furthermore, these data support the suggestion that B5 is associated with BD in populations deriving from the Mediterranean Basin, the Middle East and Fa

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01234.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Evidence is presented for a new allele at the HLA—B locus defining a new antigen, Bu. Population studies indicate a gene frequency of 0.0043 in English Caucasians. No HLA—B locus triplets involving the Bu antigen have been observed. Inheritance of Bu has been established in three informative families, each of at least three generations. Platelet absorption studies and analysis of a large number of multispecific HLA—B antisera suggest that Bu is “intermediate” between the well‐established antigens Bw

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01235.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The frequency of HL‐A antigens was determined in 31 patients with biopsy‐confirmed Wegener's granulomatosis and compared with their frequency in healthy Caucasian control population. There was no significant difference between the two groups for any of the 24 HL‐A antigens t

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01236.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In a combined Danish, American and Icelandic study, the odds for the orientationPGM3:GLO:HLA‐B:HLA‐AversusGLO: HLA‐B:HLA‐A:PGM3are estimated to be 75:1. TheGLO:HLArecombination frequency is estimated at 5% for males and 12% for females. The recombination fraction forPGM3:GLOis 12–13% in males and is significantly higher in females (approximately free recombination). The findings are consistent with the large sex differences in recombination frequency betweenH

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01237.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A total of 126 normal, unrelated individuals from northern central and southern Vietnam have been typed for 32 alleles of the A and B loci, including B HS. The gene, haplotype frequencies and A values obtained are compared with those of four other Mongoloid populations. The gene frequencies were similar to those found in a Chinese (Cantonese) population.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01238.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Juvenile‐onset diabetes mellitus (JDM) is one of the human diseases shown to be associated with histocompatibility antigens. The occurrence of serologically defined HLA antigens B8, Bw15, B18 and Cw3 is increased among these patients (Singal&Blajchman 1973, Nerup et al. 1974, Cudworth&Woodrow 1975). However, lymphocyte defined HLA‐D antigens Dw3 and Dw4 (LD 8a and LD w15a), positively associated with these serologically defined antigens, seem to be even stronger markers of susceptibility to this disease (Thomsen et al. 19

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01239.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01240.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY