摘要:

Two hundred unrelated Japanese individuals were HL—A typed with UCLA Research Tray T3 (Terasaki's Tray), which contains specificities added after the Fifth International Workshop.Phenotype, gene and haplotype frequencies were calculated with standard errors and delta values. HL—A9, HL—A5 and W10 had a higher frequency and HL—A1, 3 and 8 had a lower frequency in Japanese than in Caucasians. The frequent haplotypes were HL‐A9‐ HL—A5, HL—A9‐HL—A7 and HL—A2‐W10. HL—A9‐HL—A5 showed very positive high linkage disequilibrium parameter (delta value) and HL‐A9‐W10 showed negative high value. The sera designated as anti‐HL‐A, W5 and W15 in the T3 Tray which react identically in Caucasians showed different patterns of reaction when tested in the Japanese population.Five hundred Japanese parous women's sera were tested for cytotoxic antibodies. Some Japanese antisera showed high correlation coefficient values on HL—A2, HL—A9, HL‐A10, HL‐All and HL‐A12. The women providing the anti‐HL‐5 complex sera and their immunizing persons were HL‐A typed. These complex sera reactions were compared with the antisera in the T3 Tray. A new group of sera (SN‐1), “operationally monospecific” and cross‐reacting with W22, was found in the present study. Population and family studies suggested that the sera SN‐1 are third in frequency within the second series (phenotypic frequency 17–22%)

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01467.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Human peripheral blood leukocytes retain their capacity to function as stimulating cells in the one way MLR after freezing and storage at ‐ 70° C by a simple and inexpensive method. This storage method facilitates the use of a standard stimulating pool of cells from three donors which may provide a quantitative assay for testing the ability of cells to respond to allogeneic cells in cultu

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01468.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The spina bifida/anencephaly complex in man in some ways resembles the effects of T‐locus mutants in the mouse. To test the hypothesis that these entities are genetically related, HL‐A typing was performed in families with multiple cases of central nervous system abnormality. No evidence of linkage was found between HL‐A type and the congenital malform

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01469.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The frequency of HL—A antigens was determined in 63 myeloma patients and in 83 normal subjects. HL—A5 was more frequent among patients (15.9 %) than among controls (3.6 %). This association was significant at the 0.05 level, but the significance did not survive multiplication by the number of antigens under study.The relationship of these findings to previous work on myeloma is discussed, together with. the problems of defining components of the 4c antigenic gr

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01470.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The mixed lymphocyte reaction (MLR) between donor and recipienTlymphocytes has been measured by the macrophage electrophoretic mobility (MEM) test and the modified (MOD‐MEM) test. Its value as a measure of compatibility has been assessed by comparison with conventional HL‐A serotyping and with the outcome of renal transplantation.Thirty‐six living donor/recipient pairs and 59 cadaver donor/recipient pairs for transplantation have been studied. Whilst uniovular twins gave lymphocyte interactions, measured as macrophage slowings of about 1 %, the slowing produced by paired allogeneic lymphocytes ranged from 2 % to 26 % depending on the number of HL—A matches.The test measurement of lymphocytic interaction was significantly correlated with histocompatibility measured by HL—A serotyping, in both living and cadaver donors. One way MEM‐MLR showed the dominant role of the second HL—A sublocus in mixed lymphocyte reactivity. The long term success of the renal graft correlated with the pre‐transplant initial reaction between donor and recipienTlymphocytes.The test has advantages in the field of human histocompatibility assessment since no particular reference to individual antigens is made and it may be performed in a

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01471.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Further data on the Gb ‐ HL‐A linkage relationship are presented. All three GBG informative recombinants investigated are Gb ‐ first HL—A recombinants; therefore Gb must be situated on the second HL‐A side of the first HL—A locus. Ninety additional apparently Gb ‐ HL‐A non‐recombinant offspring from 23 matings indicate that the Gb locus is situated in close proximity to the

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01472.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Typing for LD determinants which has been practicable for some time is shown to be very predictive for the MLC response between unrelated, since LD identical individuals ‐ selected and paired solely on the basis of LD typing ‐ mutually show very low or no MLG react

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01473.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Five sera which detect two alleles of the third HL—A locus (T2 and T4) are described. Statistical analysis of a panel of 220 donors gave gene frequencies in a French Parsian population which are comparable to the results of Scandinavian author. Segregationabserved in 50 families emphssized thnkage disequilibirum with SD2 alleles. T1 was found to be associated woth the one part of W22 (Da30) and T3 with the other part (non‐Da30). No recombination was observed between SD2 and SD3, and the distace between these two loci can be estimated at less than distance between these two loci can be estimated at ess than 0.0042 U.Differential capping experiments showed that redistribution of SD3 antigens did not affect the SD2 or SD1 products, indicating that they are borne on the cell surface by independent structure. Moreover, capping of SD1, SD2 and SD3 antigens did not provoke complete redistribution of beta‐2‐microglobulin which suggests that not all β2M molecules are linked to HL—

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01474.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

In kidney transplanted patients a clear coincidence was observed between clinical signs of allograft rejection and the presence in the peripheral blood of killer cells able to lyse either PHA lymphoblasts from the actual donor or selected unrelated individuals. In recipients with non‐immunological complications such as leakage on the graft ureter or primary anuria caused by renal ischaemia, no cellular cytotoxicity against specific or selected target cells was observed.The specificity of this Cell Mediated Lympholysis in two of the cases reported could not be explained by the serologically detectable HL‐A antigens, indicating the existence of other determinants of importance for the killing capability ofin vivoproduced effector ce

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01475.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The frequency of HL‐A2 was significantly low (21 %) in patients with periodontitis when compared to controls who were free of periodontal disease (61 %). The effect was most pronounced in females in whom HL—A2 was present in 12.5 % (2 out of 16). This finding suggests that genes controlling susceptibility to microbial agents may be linked to the HL‐A

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1975.tb01476.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY