摘要:

A primary procedure for analyzing data obtained from cellular typing experiments is described. The procedure is exemplified by data obtained from primed lymphocyte testing. The data are given in sufficient detail so that the reader may, if he wishes, work through a complete analysis.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00746.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

By isoimmunization of adult virgin female rabbits with rabbit placental extracts we have demonstrated the production of humoral antibody against two antigens, Ag‐1 and Ag‐2. Neither antigen is a normal serum protein, nor are they allotype proteins. Ag‐1 has an alpha‐2 mobility and a molecular weight of about 400,000. Ag‐2 exhibits a gamma mobility but was not characterized. The antibody activity directed to Ag‐1 in immune sera was the complement‐fixing IgG fraction. Direct fluorescence‐labeled antibody technique revealed that Ag‐1 is a ubiquitous intracellular antigen primarily localized in the nucleus. The fast‐growing, SV‐40 virus‐transformed rabbit kidney cell line (TRK‐1) expressed much higher levels of Ag‐1 than the slow‐growing, non‐transformed normal rabbit kidney cell line (LLC‐RK1). The possibility that elevation of Ag‐1 production is associated with ra

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00747.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Non‐T lymphoid cells were found to be able to stimulate autologous T cellsin vitro.This “autologous” response was shown to be about 20% of the response to allogeneic unfractionated lymphocytes. The ability to induce autostimulation appeared to be a property of the Ig‐positive lymphocyte fraction. Blocking experiments with allosera recognizing HLA‐D‐associated determinants suggested that the HLA‐D determinants present on the stimulating cells might be involved in the stimulation of autol

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00748.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

At the third Japan HLA workshop, Bw40 was unanimously agreed as being split into at least two new subunits, and the existence of the Japanese specific antigen associated with Bw22 was also confirmed again.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00749.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00750.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The question as to whether the distribution of HLA antigens differs between old and young persons has been studied only in a few population groups. There are observations showing an increase of heterozygosity of the HLA system (Bender et al. 1973, Gerkins et al. 1974) which indicate an advantage of heterozygosity for survival, but other studies fail to confirm this finding (Albert et al. 1974, Mucurová et al. 1975, Bender et al. 1976). Since the present authors, in a study of HLA gene frequencies on five small Danish islands (Hansen et al. 1974) had found a tendency to a changed frequency of certain HLA types among the oldest persons, it was decided to examine this question by typing larger numbers of persons of different age groups

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00751.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00752.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

One‐hundred‐and‐eighteen cases of manic‐depressive illness, subclassified into 68 unipolars and 50 bipolars, were typed for HLA‐A and B. Both groups showed the same antigen frequencies, with the exception of a slight increase of HLA‐B15 in bipolar patients. The incidence of HLA‐Bw15 was reduced in affectively ill patients as compare

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00753.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1977.tb00754.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY