摘要:

Two hundred and eight pregnancy sera were tested for the presence of antibodies specific for lymphocyte sub‐populations by using the isolated B and T lymphocytes from the women's mating partners. This was done by the microlymphocytotoxicity and the indirect immuno‐fluorescence techniques. Five sera (2.5%) reacted exclusively with B lymphocytes and sixty‐three sera (30.2%) reacted with both B and T lymphocytes; none of the sera was specific for T cells.Several sera, reacting with both B and T lymphocytes, were absorbed with platelets and this procedure revealed nine additional antisera specific for B lymphocyte antigens.Specificity studies on a panel of forty‐eight HLA—ABCD typed individuals indicated that most antisera possibly defined new B‐cell antigens. Family studies established that the antigens defined by these antisera were coded for by genes in the Major Histocompatibil

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00814.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

HLA—A and B antigens were defined in 154 unrelated idiopathic hemochromatosis patients. The study confirmed the highly significant positive association with HLA antigens A3 (correctedP<10−10) and B14 (correctedP<10−9). HLA—DR typing showed increased frequency of the specificity DRw6, which was frequently associated with the phenotypeA3,B14and antigen B14, suggesting linkage disequilibrium. This was borne out by P

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00815.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Previous studies have shown conflicting results with respect to the relationship between C6 deficiency and the HLA system. The present investigation of two kinships, in which C6 deficiency was associated with the expression of an amorphic (or silent) C6 allele, has provided further evidence for the genetic independence of a structural C6 locus and the HLA system.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00816.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The specificity of responses in secondary MLC was studied by titration (100 × 103to 5 × 103) of responder primed lymphocytes. In all instances, significant proliferative responses of responder primed lymphocytes to the specific stimulator occurred using lower responding cell numbers. When tested against allogeneic stimulating donors, three patterns of responses were observed: no significant responses, responses only at higher (100 × 103) responding cell densities, and responses at lower responding cell densities, similar to those with the priming donor. In instances where primed lymphocytes responded significantly to allogeneic stimulating cells at lower cell densities, the responses were considered positive and the stimulating cells positive for the PL determinant. In several instances, primed lymphocytes responded significantly to allogeneic stimulators negative for the specific HLA—D and/or HLA—DR specificities. On the other hand, in experiments where allogeneic stimulating donors shared either HLA—D or DR specificity with the priming donor, a significant response was always observed. Thus, the PL determinant was present on stimulating allogeneic cells negative for specific HLA—D and DR specificities.The present data suggest that an analysis of the specificity of primed populations could be profoundly affected by the responder cell density at which the assay is performed. Also, the data suggest that other MHC determinants, including non‐HLA loci may be important in s

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00817.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Forty Japanese patients with IgA nephropathy were typed for HLA—A and HLA—B using local antisera. Thirty‐seven of these patients were typed for HLA—D using homozygous cells “En”, now known to be strongly related to DRw6. Forty‐six patients with chronic hemodialysis were used as patient controls for renal disease and 115 healthy individuals were used as normal controls. The frequency of HLA‐DEn was significantly increased in 17 out of 37 patients with IgA nephropathy, (46%) (normal controls 18.3%) (P<0.0007). Although the occurrence of HLA‐B12 was high, it was not significant, i.e. 11 out of 40 (27.5%). These results suggest that some abnormality in the genes of patients with IgA nephropathy is more closely associated with the HLA‐D region than the

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00818.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Evidence is presented for the heterogeneity of HLA‐B40. At least two sub‐groups can be recognized: Bw40.1 which is Cw3 associated and Bw40.2 which is Cw2 associated in Caucasians, but not in other populations. The recognition of Bw41 (Sabell), Bw47 (407*), and Bw48 (KSO) with both local Bw40 antisera and sera from the 7th Histocompatibility Workshop is discus

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00819.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The HLA—B8 antigen is one of the characteristic antigens associated with organ specific autoimmune diseases among Caucasians. Among the Japanese, HLA—B8 positives have been assumed to be extremely rare. By using some HLA‐B8 typing sera, a new HLA‐B antigen, HLA‐Bw4 positive, was found in the Japanese. This new HLA‐B antigen, tentatively called HOK‐1, showed a phenotype frequency of 3.7% and a gene frequency of 1.9 ± 0.6%.This antigen has a strong linkage disequilibrium with HLA‐Cw1 am

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00820.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Cold non‐HLA lymphocyte cytotoxins were found to be principally reactive against B lymphocytes. These antibodies were studied in 1335 patients with a wide range of diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, Hashimoto's disease, asthma, diabetes, lymphoma, psoriasis, leukemia, multiple sclerosis, and also in healthy donors. Antibodies reactive to B lymphocytes in the cold or warm test conditions were not directed against HLA specificities. Since B lymphocytes differ from T lymphocytes principally in that they have surface immunoglobulin, it is postulated that at least one target antigen of cold lymphocyte cytotoxins is not a virus, infectious agent, or a genetically determined structural antigen, but, rather, simply immunoglobuli

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00821.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A simulation of the matching for HLA‐DR, B, A loci was achieved by taking into account the practical situation of kidney transplants for 89 donors and 322 potential recipients.A complete HLA‐DR identical graft was theoretically possible in 52% of the cases. Conversely, if the identity for B or particularly the identities for both B and A were sought, the necessary pool of recipients would have to be much larger, requiring intense international cooperat

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00822.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Investigation of a group of 23 patients suffering from subacute (de Quervain's) thyroiditis for the frequency of the HLA‐Dw1 determinant showed this determinant to be more frequent ‐30.4% ‐ compared to its frequency in a healthy population — 19.1%. The finding is not statistically sign

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1979.tb00823.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY