ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01265.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In a collaboratory study involving eight different laboratories 30 human, mixed lymphocyte culture educated cytotoxic/ymphocytes (CTLs) were identified yielding reproducible cytolysis on allogenic lymphocyte target cells without detectable HLA—A, B (and C) antigenic sharing between stimulator and target cells.These CTLs were collected in one laboratory (Aarhus) and tested in parallel against a population sample of 100 unrelated, healthy Danes. The testing was only performed once and 11 CTLs did not discriminate in the population, probably due to transportation damage. On the basis of pairwise comparisons between 19 CTLs, three tentative CML‐defined specificities could be recognized. These three groups may have defined monospecific traits of allelic genetic origin as judged by a mutually negative, albeit not significant, correlation and a fit to Hardy‐Weinberg equilibrium.The concept of determinants other than the serologically defined HLA antigens recognized by some CTLs can thus still be maintained as can the approach to CML typing tested in this wor

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01266.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A serological comparison has been made between individuals who are phenotypically Cw1 and Cw3. The first individual is Oriental and carries Cw1 and Cw3 on the same hapiotype, the other individuals are Caucasian and carry either Cw1, Cw3 or Cw1 and Cw3 on different haplotypes. No unique specificities could be found on the Oriental Cw1, Cw3 hapiotype by reciprocal absorption experiments, inhibition of complement dependent microcytotoxicity by F(ab')2fragments prepared from Cw1 and Cw3 antisera or by lysostrip experiments. The blocking and lysostrip experiments also suggested molecular independence of Cw1 and Cw3 determinants coded for by Oriental Cw1, Cw3 hapiotype. The results suggest a recent gene duplication in Oriental populations or two loci in theCregion.

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01267.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Upon evaluation of 40 subjects with progressive systemic sclerosis (PSS), a significant association of HLA antigens A9 and Aw24 (a subgroup of A9) was found with diffuse scleroderma. HLA—Aw23 (a second subgroup of A9) was also increased in the patients, however, this was not statistically significant. Diffuse scleroderma appears to be one of the few diseases that shows an association with the HLA—A lo

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01268.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The tissue specificity of colonic mucoprotein antigen (CMA) was examined to determine whether the antigen might have a role as a tissue marker. The immunofluorescent technique, using a rabbit anti‐CMA antiserum, was employed to examine a wide range of tissues. Gastrointestinal mucosae as well as non‐gastrointestinal mucin producing tissues were positive; however, non‐gastrointestinal reactivity could be eliminated by the appropriate absorptions. Mucoproteins were purified separately from each gastrointestinal anatomic region and used to absorb the antiserum. This analysis demonstrated the existence of a family of mucoproteins with a common gastrointestinal specific determinant(s). Mucoproteins from neighboring regions, as seen by this antiserum, showed a greater structural similarity than did mucoproteins from distant regions. Absorption of the antiserum with ileal or cecal mucoprotein allowed the detection of a colon specific determinant present o

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01269.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The molecular relationship of HLA—D‐associated by B lymphocyte antigens was studied in lysostrip, immunofluorescence and MLC inhibition experiments. Two B cell antigens, strongly associated with HLA—Dw2 and—Dw3 respectively, redistributed independently of each other in the cell membrane. A more broadly reacting B cell antiserum, which apparently recognized a public antigenic structure present on B cells of different HLA—D phenotypes, coaggregated with the HLA—Dw3‐associated B cell antigen. Antibodies directed against the HLA—Dw2 and—Dw3 associated cell antigens caused specific stimulating cell inhibition in MLC. Less. inhibition was observed if the target B cell antigen was shared between the responding and stimulating cell donor and thus did not constitute an allogeneic difference, indicating that these antigens are MLC stimulating determinants and that they reside on separate molecules in

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01270.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0001-2815    

DOI:10.1111/j.1399-0039.1978.tb01271.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY