摘要:

SUMMARYCutaneous involvement may occur with virtually all syndromes of vasculitis. This can occur primarily as a dermatologic disorder or as a manifestation of a potentially life threatening systemic vasculitis. In this review article, classification, clinical manifestations, pathogenesis and therapy of cutaneous vasculitis will be discussed. Disorders which are primarily vascular in origin but lack a well defined inflammatory phase, referred to as ‘vasculopathies’ will also be discus

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00952.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYThe pathogenetic mechanisms underlying common, and less common but severe, adverse cutaneous drug reactions are reviewed. Pharmacogenetic variability may account for a susceptibility to serious drug reactions to sulphonamides and anticonvulsants, as well as to lupus erythematosus (LE)‐like syndrome. Exanthematous drug reactions may have an immunological basis. Cell mediated cutaneous drug reactions, including lichenoid reactions, LE‐like syndrome, fixed drug eruption, erythema multiforme, Stevens‐Johnson syndrome and toxic epidermal necrolysis, will inevitably involve elements of the skin immune system. Graft‐versus‐host disease provides a useful model for aspects of these drug‐induced disorders. Urticaria, angioedema, anaphlyaxis and anaphylactoid reactions may involve Type I immunoglobulin (Ig)‐mediated or Type III hypersensitivity, or may be caused by pharmacological, non‐allergic means. Drug‐induced vasculitis, serum sickness and the Arthus phenomenon are manifestations of the immune complex disease. Drug‐induced pemphigus may involve immune dysregulation, but several thiol‐containing drugs are able to cause antibody‐independen

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00953.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYPlant visits are an invaluable tool in the management of work‐related skin disorders, as they are the means by which a dermatologist gains firsthand information about the circumstances under which a work‐related skin disorder has arisen in a plant or factory. In order to manage the workplace hazards which are responsible for skin disease, these must be identified and evaluated, and recommendations made about their control. While it may be possible to do this vicariously by questioning, examining, and investigating affected workers in the office, site visits to the plant or factory are sometimes necessary for the optimal assessment and management of such cases, as they often provide valuable information and insights not forthcoming from the history, examination, and investigations. This article explores the rationale behind plant visits, and discusses the pre‐visit assessment, pre‐visit preparation, the plant visit itself, and post‐visit responsibilities. Practical advice is given for conducting each of the

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00954.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYCryosurgical treatment of skin cancer and premalignant conditions of the skin has been in widespread use for 20 years. Data accumulated over this period suggest that if attention is paid to the treatment technique and to lesion selection, then cure rates equivalent to radiotherapy, simple surgical excision, and curettage and cautery can be achieved reliably. Moh's micrographic surgery offers a higher cure rate for skin cancer, but is not suitable for the vast majority of lesions seen in clinical practice. The decision to use cryosurgery to treat any particular lesion will therefore be influenced by a number of other considerations. Cryosurgery competes well on morbidity and cosmetic outcome and is the quickest, easiest, cheapest and most readily available of the treatment options. As such it has earned its place among the recognized treatment modalities for skin cancers as well as premalignant conditions of the skin. Cryosurgery is commonly delivered empirically without record of the dose delivered and without audit of the outcome. The aim of this review is to describe in detail one standard technique of therapy that is easily reproduced and has been audited; the timed spot freeze technique. This technique can be used, even by those inexperienced in cryosurgery, to achieve predictable success rates. Many other techniques do exist, but either have not been audited or are unnecessarily cumbersome.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00955.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYComputer image analysis enables large numbers of hairs to be measured in an automated fashion. In this study, we examined horizontal scalp biopsies from 10 patients with a histological diagnosis of androgenetic alopecia and 10 normal control subjects. The density of hair follicles and the ratio of terminal to vellus hairs were determined. Hair shaft, hair canal and hair follicle diameter, inner root sheath width and outer root sheath area were measured using the Chromatic Colour Image Analysis program. This study showed a statistically significant progressive decrease in size of hair canal diameters from normal terminal hairs (85.93 ± 10.07 μm) through to androgenetic alopecia terminal (68.83 ± 13.60 μm) and vellus hairs (28.67 ± 5.60 μm). This pattern is also seen with hair follicle diameters; normal terminal (268.41 ± 24.88 μm), androgenetic alopecia terminal (236.34 ± 17.23 μm), and vellus hairs (130.88 ± 19.96 μm). Outer root sheath areas, hair shaft diameters and ratio of terminal to vellus hairs were significantly larger in normal (18500 ± 4222 μm2; 82.71 ± 13.79 μm; 36:1; respectively) compared with androgenetic alopecia scalp biopsies (8403 ± 3322 μm2; 61.11 ± 14.42 μm; 3:1; respectively), whereas inner root sheath width and density did not vary significantly. Computer image analysis can be adapted for use in clinical trials where large numbers and objectivity are critical in determining the efficacy of ha

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00956.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYBiopsy specimens from 211 cases of mycetoma were examined histologically. Pale grain eumycetoma was found in seven cases. Four of these were studied mycologically,Acremonium kiliensewas isolated from two andAcremonium falciformeandPseudallescheria boydiifrom one case each. The geographic distribution of these organisms, and their incidence and prevalence are discussed.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00957.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYWe report a case of Ehlers‐Danlos syndrome Type II presenting with subtle clinical features and discuss the importance of early recognition of this disorder. A 16 year old Caucasian schoolgirl presented with soft tissue swellings on her fingers. There was a history of poor wound healing and prematurity and a family history of miscarriages. Clinical examination revealed hypermobile joints, hyperelastic skin and a ‘cigarette paper’ scar at the site of a previous minor surgical excision. Management consisted of genetic counselling and advice concerning career choice, recreational activities, as well as future pregnancy and surgery. This subtype of Ehlers‐Danlos syndrome is probably fairly common in the community. While it may present with subtle clinical features, recognition is important so that counselling can be offered at a young age in order to avoid the major consequences that may arise during pregnancy and

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00958.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYSymptomatic zinc deficiency developed in a breast‐fed premature male infant of 31 weeks gestation. At 13 weeks of age he presented with diarrhoea, irritability and an eruption identical to acrodermatitis enteropathica. Breast milk zinc concentrations were low. His course was complicated by milk protein intolerance. After 7 weeks, zinc supplementation was ceased without recurrence of diseas

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00959.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYLymphocutaneous sporotrichosis presented in a 10 year old child 1–2 weeks after an abrasion. A series of nodules, two of which ulcerated, appeared along the arm with tender unilateral axillary lymphadenopathy in the absence of systemic symptoms. Biopsy showed a granulomatous infiltrate but failed to reveal the organism; however, culture was positive forSporothrix schenckii. The primary lesion healed with a scar after 3 months of systemic therapy with potassium iodid

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00960.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

SUMMARYA case is presented with tender swelling and nail bed hyperplasia in 2 fingers. Histopathology revealed Bowen's disease in both fingers and after amputation, invasive squamous cell carcinoma in one finger.

ISSN:0004-8380    

DOI:10.1111/j.1440-0960.1995.tb00961.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY