摘要:

Basal cells of human bronchioles were studied by light and electron microscopic histochemistry, and compared with basal cells of major bronchi. Bronchiolar basal cells were found isolated or in isolated groups of a few linked cells. On the other hand, the basal cells of the major bronchi form virtually continuous layers covering the basement membrane. Bronchiolar basal cells were different in ultrastructure and alkaline phosphatase (ALP‐ase) activity from basal cells of major bronchi. Bronchiolar basal cells showed intense ALP‐ase activity on the plasma membrane, but basal cells of the major bronchi showed no activity. Basal cells of bronchioles were flattened, triangular or trapezoid in shape, and showed different organelle features from those of basal cells of major bronchi. ALP‐ase positive bronchiolar flattened basal cells with pinocytoic vesicles were not myoepithelial cells, since actin was not demonstrated by immunohistochemistry. The role of basal cells in the renewal of epithelium appeared to be that of stem cells in both major bronchi and bronchioles, since basal cells of bronchioles appeared to differentiate directly to Clara cells, and to become ciliated cells via intermediate

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02105.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A case of an epidermoid carcinoma which arose in a cystic adenolym‐phoma‐like lesion of the parotid gland is presented. Histologically, in the major part, the tumor tissue showed a papillary cystadenoma lymphomatosum‐like pattern with the stroma consisting of mainly plasma cells and lymphocytes, but the epithelial element was mostly multilayered, showing a keratinous differentiation. In some areas, sebaceous‐like cells and oxyphilic cells were found in the epithelial component. In the surrounding fibrous tissue, the invasive growth of the epithelial cells could be observed. Microdeposit of amyloid substance was found in the lymphoid stromal tissue and also in the intercellular space of the epithelial element. A mass of epithelioid cells and cholesterol crystal clefts were observed in the granulomatous tissue which proliferated around the tumor tissues. About 4 months after surgical excision, a recurrent tumor, which was well differentiated squamous cell carcinoma, appeared on the same site as the primar

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02106.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

An autopsy case of acute thyroiditis in acute lymphocytic leukemia is presented. The thyroiditis was mycotic and developed severe necrotic inflammation with a hemorrhage and a perithyroidal abscess, and resulting in disseminating mycosis with multiple microabscesses in both kidneys and in myocardium.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02107.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A case of duodenal somatostatinoma is reported. The patient, a 54‐year‐old male, had complained of an epigastric pain due to gastric ulcer and a duodenal polyp was unexpectedly found at a gastrectomy. The polyp showed basically tubular adenocarcinoma, with negative argyrophil and argentaffin reactions. By an indirect immunofluorescent examination almost all of the tumor cells were revealed as somatostatin‐immunoreactive. Big somatostatin was also positive. Radioimmunoassay of the tumor indicated 6400 pg of somatostatin‐like immunoreactivity per milligram of wet tissue. This seems to be the second case of duodenal somatostatinoma, following the case reported by us pre

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02108.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

An unusual case of Cushing's syndrome of a 59‐year‐old man with bilateral multinodular adrenal hyperplasia and microadenoma of the pituitary gland is presented. Failure to suppress plasma Cortisol with large doses of dexamethasone may suggest autonomous growth of hyperplastic nodules of the adrenals, which were at first induced by prolonged stimuli of ACTH from the microadenoma of the pituitary gland. ACTH could not be detected in the microadenoma cells on paraffin sections, while Crooke's cells were strongly positive for ACTH. The interrelation between bilateral multinodular adrenal hyperplasia and pituitary microadenoma is discus

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02109.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A rare autopsy case of undifferentiated carcinoma of the parotid gland with bizarre giant cells is reported. Grossly, the tumor was fist‐sized, firm, solid, grayish‐white in color, and was not encapsulated, with a bean‐sized ulceration on the skin. Microscopical examination revealed undifferentiated carcinoma of the parotid gland composed of bizarre giant cells, large tumor cells, and spindle cells in part. Ultrastructural examination, recovered from formalin‐fixed material, disclosed filamentous structure in some large tumor cells. It is strongly suggested that myoepithelial cells played an important role in the development of the undifferentiated carcinoma of the parotid gland. The clinical and histopathological characteristics of this case is described, and the literature concerning undifferentiated carcinoma of the parotid gland is r

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02110.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

An autopsy case of primary hepatic fibrosarcoma with severe hypoglycemia is reported. Only two cases have been previously reported. Histological features were well differentiated and partly indistinguishable from those of fibrous mesothelioma.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02111.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A 52‐year‐old man with a clinical diagnosis of aortitis and heart failure died of brain thrombosis. Autopsy revealed many non‐caseous sarcoid granulomas scattered in lymph nodes, lungs, heart, testes, liver, and meninges. An unusual finding of this case was the presence of sarcoid lesions in abdominal aorta and subclavian and common iliac art

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02112.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A case of cervical thymoma in a 51‐year‐old female is reported. The tumor was located on the left side of the anterior neck just beneath the left lower lobe of the thyroid gland and there was no connection to the mediastinal thymus gland. It was well encapsulated and lobulated on the cut‐surface. Histologically, the tumor showed a mixed proliferation of lymphocytes and epithelial cells. Mitoses were frequently seen. Several tiny fragments of ectopic thymic tissue were found around the tumor. Cervical thymic tissue, considered to be the original site of the cervical thymoma, was studied and found macroscopically in 12 out of 657 patients with Basedow's disease (

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02113.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY