摘要:

A large, poorly demarcated, elevated lesion over the area ranging from the lower end of the esophagus to the lesser curvature of the cardiac region was examined in a 19 year old woman, and demonstrated an irregular and highly infiltrative proliferation of spindle cells over the full thickness of the gastric wall. Although the spindle cells grew mainly in the submucosa, they penetrated the muscularis propria, leaving intact muscle tissue that formed an irregular, island‐like pattern, and reached the subserosa. The cells were identified as myofibroblasts by light microscopy, immuno‐histochemistry and electron microscopy. The present case is considered to be of an inflammatory pseudotumor due to extremely infiltrative growth of myofibroblasts. This lesion differed from inflammatory fibroid polyp (similarly consisting of proliferating myofibroblasts accompanied by inflammatory cells) in terms of age at onset, tumor size, pattern of cell proliferation and main inflammatory cell component. This report also discusses the relationship between this lesion and a very recently advocated new entity, inflammatory fibrosarcoma of the mesentery and retroperito‐neum, which is a tumour closely simulating inflammatory pseudo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02916.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

A primary leiomyosarcoma of the thyroid gland in a 72 year old Japanese woman is described. This is the second case reported in the English literature. The patient presented with a 7 month history of a gradually expanding tumor in the right neck. The surgical specimen taken by thyroid lobectomy revealed a relatively well demarcated tumor, 2X2X3 cm in size, confined to the right lobe. Histologically, the tumor showed a classical leiomyosarcomatous appearance of interlacing fascicles of spindle‐shaped cells with occasional blunt‐ended nuclei and a high frequency of mitotic figures. lmmunohistochemistry of the tumor cells clearly showed smooth muscle differentiation; the cells were positive for desmin, muscle‐specific action and vimentin and negative for cytokeratin, epithelial membrane antigen, carcinoembrionic antigen, thyroglobulin and calcitonin. The patient was free of disease for 3 years and 11 months without further treatment when evidence of multiple bone metastases appeared on bone scintigraphy. She died of pneumonia 4 years and 3 months after the lobe

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02917.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

A case of pulmonary artery leiomyosarcoma in a 37 year old Japanese man is reported. The patient complained of chest pain and hemosputum. CT scan and angiography revealed that a tumor arose from the right main branch of the pulmonary artery. The surgical specimen was interpreted as an undifferentiated sarcoma at this time. The tumor recurred 6 months after the resection, and he died of right‐sided heart failure. At autopsy, the pulmonary artery truncus was distended by the tumor, which protruded into the lumen. The tumor was composed of pleomorphic cells, giant cells and spindle‐shaped cells. Many of the tumor cells were immuno‐histochemically positive for alpha‐smooth muscle action and vimentin. Electron microscopy revealed microfNaments with dense bodies in the cytoplasm and a discontinuous basement membrane around the cells. Although adenocarcinoma was also observed in the colon, the authors conclude that the present tumor is not a metastasis but a primary leiomyosarcoma arising from the pulmonary artery. Imaging techniques were very useful for differentiating sarcoma from thrombus in this site, and immunohistochemical demonstration for alpha‐smooth muscle action was necessary for making a histological diagnosis of leiom

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02918.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

We describe a case of well differentiated adenocarcinoma of the gall‐bladder that arose from a localized type of adenomyomatosis. Grossly, the cancer was located in the fundus and exhibited a polypoid and well demarcated nodule with multiple small cysts. Histologically, the nodule consisted of glandular structures and stroma containing bundles of smooth muscle cells. The glandular epithelia were varied in appearance, ranging from malignant to benign glands. The adenocarcinoma was limited to the nodule, with normal surface mucosal epithelia and without obvious stromal invasio

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1993.tb02919.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY