ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03001.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryBy repeated administration of fumaric acid which belongs to the Krebs's TCA Cycle and which is influentially connected with the metabolism in body, the rabbit develops slight regressive changes in its parenchymatous organs, as well as a parenchymatous goiter. Marked atrophy is observed in the gonads especially accentuated in the testis, a correlated decrease in hyaluronidase being recognized in the atrophied testis. In this case two types are developed, i.e., hypergonadotropic hypogonadism and hyperestrogenic hypogonadism. The administration of the serum of hypergonadotropic hypogonadism to virgin rabbits results in the development of maturity of follicles with seems to be related with ovarian cystoma. Gynecomastia is observed in hyperestrogenic hypogonadism.The atrophy of testes following repeated administration of fumaric acid is inhibited by the combined administration with RNA or DNA, and with histidine. It is assumed that the fumaric acid is directly correlated with a biosynthesis of pyrimidine base. So, it is concluded that the etiological mechanism of the marked atrophy of gonads, especially the testes, is interpreted as a direct metabolic influence to the nucleic metabolism of germinal cells, and the metabolic disturbance in body influences the gonads, and the endocrine glands.The atrophy of gonads and the production of arteriosclerosis of aorta on rabbits due to the TCA Cycle disturbance seems to have given a significant value in clarifying the so‐called aging or senile symptom

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03002.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryAn autopsy case of chronic rheumatic carditis is described. The patient was a woman aged 32 years and the duration of the disease was more than eight years.At autopsy, the heart showed typical mitral stenosis with verrucous scarring, calcification and contraction of the valve. Areas of degenerating muscle cells and proliferation of the interstitial connective tissue, partly with perivascular infiltration, were seen throughout the myocardium, and heart muscles showed narrowing and fragmentation. There was fibrinoid degeneration of the wall in small coronary vessels. Numerous Aschoff bodies of various structures were found mostly in the proliferated interstitial connective tissue, between damaged muscle bundles and adjacent to the small coronary vessels of the myocardium. A small number of Aschoff bodies were situated in the subendocardial tissue in which there was no muscle.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03003.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryWe examined the myocardium on the occurrence, changes with age, distribution and character of fibrosis and its factor with large specimens taken from 348 male cases and 181 female cases which were picked up at random out of autopsy cases.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03004.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryAn autopsy case of the so‐called giant cell myocarditis, which was understood to be sarcoidosis, the main lesion of which situated in the myocardium, was reported.In the morphogensis of asteroid bodies, the protein moiety of lipoprotein was considered to participate. The theory that these bodies would be derivatives of elastin could not be supporte

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03005.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryThe lesions of this disease are seen mainly in the trunks of larger and medium sized arteries where focal coagulation necrosis and granuloma consisting of epithelioid cells and giant cells of Langhans type occur primarily, and these focal changes extend to the surrounding area forming irregular scar tissues and in turn cause a diffuse productive inflammation of the arterial walls. Such lesions seem to begin centering at the vasa vasorum in adventitia and media, and changes in the intima or formation of thrombi are interpreted to be secondary. It is important to note that marked thickening of the arterial wall in some portions is found immediately after branching off, while no changes are visible proximal to the branching.From these findings it is proposed that the preferable designation for this disease is Trunco‐arteritisDiffusa(or Granulomatosa) Productiva.In this case, marked stenosis due to thickening of the wall of the left subclavian artery causes an absence of radial pulsation of this side, that of the renal arteries brings about degenerative changes in both kidneys, and marked stenosis of the short gastric arteries causes an ischemic necrosis of the stomach wall, through which perforations occur.Atypical tubercle bacilli of viral type are suspected as the etiologic factor of this disease. In has been said that this disease occurs most frequently among women in puberty, and therefore, this is the first autopsy report of a boy in the first decade such as 5 years of ag

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03006.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

A sporadic outbreak of encephalopathia from unknown causes was experienced at the farming and fishing area facing the Bay of Minamata (1×2.5 km), having about ten thousands population, through the end of 1953 up to 1956. Seventeen out of all fifty‐six patients died during the period. The disease was noticed throughout a year, but the‐incidence was relatively more numerous from spring to autumn. The clinical symptoms demonstrated numbness around the mouth and of fingers in the beginning stage, but with no fever to the end. And then ataxia, hypertonic staggering gait, tremors of fingers, impairment of speech, difficulty of hearing, and restriction of the visual field were seen in some of these patients. In a severe case, the disturbance of the involuntary motion such as intention tremor, blindness, choreiform movement, athetosis and ballismus were recognized. Furthermore, dysphagia, muscular rigidity or hypotonia of muscles followed. In the terminal case, the disturbance of the coordination of feeling with condition leading to impaired consciousness was observed, and finally the patients fell into cachexy and died of pneum

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03007.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryThe authors have carried out investigations on horses with cerebral symptoms clinically, pathologically, and epidemiologically which were obtained in various areas in Hokkaido in non‐epidemic years—1955, 1956 and 1957. Among cases investigated, there were three cases in which the authors could certainly prove the existence of encephalitic changes histopathologically in addition to two cases, one being positive to the complement‐fixation test and the other in virus isolation. In five out of eighteen cases investigation, slight leucocyte emigration was observed in the brain tissue. Comparing such facts with the judgement from the viewpoint of epidemiology and differential diagnosis, the authors have concluded that all of the cases with encephalitic symptoms were infected with Japanese encephalitis (Encephalitis epidemica japonica). They have also added considerations pertaining to the infection‐pathology of Japanese encephalitis based upon the discrepancies in infected horses between epidemic and non‐epide

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03008.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03009.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY

摘要:

SummaryRegarding primary aldosteronism, 24 cases have been already reported since Conn made his first description, but among them only three were autopsy cases. Although this case had no periodic paralysis nor tetany, the existence of such findings emphasized by Conn, namely confirmation of adrenocortical adenoma and its greater content of aldosterone, hypokalemia and the existence of the conspicuous hydropic degeneration in the tubular epithelium of the kidney and other clinical findings may indicate a primary aldosteronism.There have been no reports of malignant nephrosclerosis which was based upon primary aldosteronism. Although the probability that the malignant hypertension and adrenocortical adenoma co‐existed independently could not be wholly denied, at least in this case because of the greater amount of aldosterone in the adrenocortical adenoma, being proved in the clinical examination, it would be reasonable to consider that the hypertension may have occurred as a result of the hypersecretion of aldosterone and from this condition malignant nephrosclerosis might have been develope

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1957.tb03010.x

出版商:Blackwell Publishing Ltd    

年代:1957

数据来源: WILEY