摘要:

An autopsy case of malignant fibrous histiocytoma (MFH) with widespread metastases and lung carcinoma in a 64‐year‐old Japanese woman is reported. The initial signs were cough and sputum, followed by hemosputum. A chest X‐ray photo showed a right pleural tumor, which could not be identified from a biopsy specimen, but was identified as MFH by light and electron microscopic studies on biopsy specimens of tongue tumors. Autopsy examination revealed metastases of the MFH to the brain, lung, liver, kidney, adrenal, pancreas, retroperitoneum, and some bones, and pulmonary adenocarc

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01465.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Ultrastructural and immunohistochemical studies on an appendiceal carcinoid tumor in a 53‐year‐old man disclosed an intimate association of nerves and tumor cells. Electron microscopy revealed that the tumor nests were composed of neurosecretory cells containing neurosecretory granules and peripherally‐located Schwann cells encasing axons. Some tumor nests were continuous with nerve fibers invested in the common basal lamina. These findings suggest that at least some carcinoid tumors of the appendix show intra‐nerve fiber growth, and that the neurosecretory cells might be present in the nerve fibers from the beginning or infiltrated into the nerve fibers at a very early stage of neoplastic transfo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01466.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

A 56‐year‐old Japanese man was admitted to the hospital with a large mass in his right axilla. Histological investigation revealed that it was a Burkitt's lymphoma. Ultrastructures of the tumor cells showed immature lymphoid features with frequent lipid droplets within the cytoplasms. Virological studies before the treatment revealed that the lymphoma was closely related to EB virus infection, being positive for EBNA (more than 95% of all tumor cells) and IgG antibodies to VCA (× 5, 120), EA (× 640), and EBNA (× 160). The tumor cells exhibited low levels of cytoplasmic IgM and other properties of B cells. They were positively stained with L26, L27, Leu 14, and HLA‐DR MAb. In cultured tumor cells, L25 and CALL? antigens were demonstrated, but no surface Ig was shown. In contrast, the tumor cells were negative for T cell markers including AcP, E‐receptor, and Leu 1, 2, and 3. Cytogenetic studies demonstrated that the karyotype of the tumor cells was 46, XY, dup (1q), t(2; 8)/46, X, ‐Y, t(2;8), +mar. VEMP therapy was immediately conducted. However, following a two‐month partial remission, a relapse with bone marrow infiltration occurred. Thus, a case of Japanese Burkitt's lymphoma with EBNA (+) and t(2;8) properties is described, and the relationships among primary sites, phenotypes, and genotypes

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01467.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

An autopsy case of Cornelia de Lange syndrome with intracranial germinoma is reported. Clinically, the patient was diagnosed as having this syndrome at one year of age, she was found to be suffering from diabetes insipidus at 18 years of age and soon she had an accidental death.The autopsy disclosed that the tumor grew from the hypothalamus to the optic nerve and the posterior lobe of the hypophysis. Microscopically, this tumor was a germinoma with a “two cell pattern”. On the other hand, examination by peroxidase‐antiperoxidase complex (PAP) method of the anterior lobe of the hypophysis demonstrated that thyroid‐stimulating hormone (TSH) and follicle‐stimulating hormone (FSH) producing cells had

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01468.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Immunohistochemical and electron microscopic examinations were made of a carcinosarcoma of the esophagus in an 80‐year‐old man. An immunohistochemical examination showed that sarcomatous spindle cells were vimentinpositive, whereas squamous carcinoma cells were keratin‐positive. No coexistence of vimentin and keratin in a single tumor cell was found. Electron microscopically, the sarcomatous spindle cells were characterized by well‐developed rough endoplasmic reticulum, abundant intermediate filaments, and the occasional presence of peripheral aggregates of microfilaments. No definite desmosomes were identified among these cells. These results appear to indicate that most of the spindle‐shaped tumor cells assume fibroblastic cellular features and synthesize the intermediate filament protein usually expressed in mesenchymal cells, even though such tumor cells could be epithelial

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01469.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY