摘要:

Among well differentiated thyroid tumors, oncocytic neo plasms feature a distinctive set of clinical, morphologic and biologic characteristics, some of which have been a matter of controversy. The world literature on this subject has been reviewed to show that: 1) Morphology accurately predicts the behavior of Hurthie cell tumors assuming that the specimen has been adequately sampled; 2) Capsular and/or vascular invasion is thesine qua noncondition for a diagnosis of malignancy; 3) “Indeterminate” or “pos sibly malignant” categories are useless because in the absence of invasion these neoplasms almost invariably behave in a benign fashion; 4) Among cases histologically classified as malignant, a clinically aggressive behavior is to be expected in a high percentage of cases; 5) Size alone cannot be used as a criterion of malignancy; 6) Less than total thyroidectomy provides an adequate treatment for histologically benign tumors; aggressive surgical proce dures (i.e. total thyroidectomy) do not diminish the inci dence of metastasis; 7) Analysis of DNA content may be helpful in defining subsets of patients with Hurthle cell carcinomas having a particulaly poor prognosis; 8) Mito‐chondrial and/or nuclear DNA abnormalities probably play an important role in the cellular alterations which charac terize the phenotype of oncocytes. Acta Pathol Jpn42: 305

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02879.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The pathogenesis of fetal brain damage caused by acute maternal hypoglycemia was investigated experimentally in cats: profound hypoglycemia (blood glucose concentration:less than 30 mg/dl) was induced in 12 pregnant cats at various stages of gestation by intravenous bolus injections of insulin. Maximal hypoglycemia was attained within 2 3 h, although the grade and duration in individual cats varied. The EEGs of all of seven maternal cats examined showed an increased frequency of slow high‐voltage waves as hypoglycemia progressed, eventually becoming flat in 3 for a maximum period of 20 min. Some fetuses showed severe neuropathological changes, such as infarction or intrauterine death. Subventricular soften ing, cortical hemorrhage and ischemic neuronal changes also occurred, being distributed symmetrically in the para‐sagittal areas of the cerebrum, basal ganglia, thalamus and tegrnentum of the brainstem. In general, these patho logical changes were more marked in fetuses and neonates than in the maternal cats, in which only ischemic neuronal changes were present, and may have been due to fetal systemic hypotension and cerebral ischemia induced by hypoglycemia. In maternal cats, the distribution of neu rons showing ischemic changes was widest in the cerebral cortex, and some were also present in the dentate gyri of the hippocampus. Moreover, ultrastructural examination of the ischemic neurons in maternal cats, unlike those of the fetuses, showed no mitochondrial swelling. Therefore, the distribution and ultrastructural nature of the ischemic neurons found in the maternal cats were considered to be characteristic of hypoglycemia, as proposed by Agardhet al. (1980). Acta Pathol Jpn42: 316–324,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02880.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Severe glomerulonephritis was induced successfully in (B1OxDBA/2)F1(BDF1) mice by injection of parental DBA/2 lymphoid cells. The mice manifested typical ne‐phrotic syndrome dying around 10 weeks post injection. Electron microscopical examination demonstrated electron dense deposits first in the mesangial matrix, then in the subepithelium compatible with immune complex glomerulonephritis. Subendothelial deposits were not ob served. lmmunofluorescent study revealed IgG deposition in the capillary wall and IgM in the mesangium early in the process. As the lesion progressed, both IgG and IgM were present in the mesangial area and along the capillary wall. Some glomeruli showed segmental mesangiolysis, suggest ing that altered mesangial cells have a role in the develop ment of glomerular change, which together with rise in serum anti‐DNA antibody titer suggest that autoantibodies promote the glomerular lesions in this model system. Acta Pathol Jpn42: 325–332,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02881.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The clinicopathologic and immunohistological features of 20 Japanese patients with non‐Hodgkin's lymphomas (NHLs) limited to the sinonasal area were studied using a broad panel of T‐ and B cell markers on paraffin‐embedded and fresh frozen tissue. All cases showed a diffuse growth pattern. Nine cases were B cell lymphomas (immunoblas‐tic n = 4, centroblastic n = 3, immunocytoma n = l, centrocytic n = l), and nine were T‐cell lymphomas (pleomorphic medium and large cell n = 8, angioimmuno‐blastic n = 1). In two cases, the cell lineage could not be determined. No morphologic features of angiocentric/an‐giodestructive lymphoproliferative lesions or lymphoepithe‐lial lesions in ductal or glandular epithelium were seen in our series. Eight (89%) of the nine T‐ cell tumors and four(44%) of the nine B ‐ cell neoplasms involved both the nasal cavity and paranasal sinuses. Six of the nine T ‐ cell neoplasms showed a clinical presentation of rhinitis, whereas all of the B ‐ cell neoplasms showed tumor masses in the nasal cavity and/or paranasal sinuses. The two‐year survival rate for T cell lymphomas was poorer than that for B‐cell lymphomas. The five‐year survival of patients with NHLs involving both the nasal cavity and paranasal sinuses was also poorer than that of patients in whom NHLs were limited to the nasal cavity. Ac

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02882.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We have examined the distribution of antigens detected by MB1, MB2 and MB3 on non‐hematopoietic normal human tissues and various types of benign and malignant tumors. MB1 and MB2 reacted with various organs, such as the epithelium of various glands, smooth muscle cells, vascular endothelial cells, and peripheral nerve tissue. The distributions of these two antibodies were essentially identical. Reactivity with MB3 was confined to the ductal eDithelium of salivary glands, the pancreas, and sweat glands, and the cortex of the adrenal gland. lmmunoblotting analysis demonstrated that MB1 and MB2 reacted with a few bands of an extract of myometrial cytoskeletal fraction and salivary gland cytosol fraction, whereas MB3 failed to show any bands on these materials. The reactivities of MB1 and MB2 with various neoplasms were similar to those in normal organs, with slight variations of staining pattern and preponderance in well differentiated tumors. Exceptionally, carcinoid tumor and small round cell tumors, such as small cell carcinoma or neuroblastoma, were not reactive with MB1 and MB2. MB3 reacted with several cases of well differentiated benign and malignant epithelial tumors in various organs, and exceptional cases of malignant schwannoma and glioma. These results indicate that the antigens detected by MB1 and MB2 are distributed broadly on non‐hematopoietic normal organs, whereas those detected by MB3 are confined to exceptional cases of epithelial and non‐epithelial tumors. Thus, although the use of MB1, MB2 and MB3 is of little value for differential diagnosis of various tumors, these three antibodies may be useful for determining of the origin of some tumor types. Acta Pathol Jpn 42: 339–34

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02883.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Three helper T cell lines, designated CR ‐IIA (CR‐IIA‐1, CR‐IIA‐ 2, and CR‐IIA‐3), were established by coculturing nor mal human cord leukocytes with a lethally irradiated HTLV II (human T lymphotropic virus type II)‐ infected rabbit leukocyte cell line (Ra‐IIA). CR IIA had a normal human karyotype and expressed the surface markers CD3(+), CD4(+), CD8(‐), CD19(‐), CD25(+) and HLA‐ DR(+), confirming their helper T cell nature. CR‐ IIA cells were all free of Epstein‐ Barr virus nuclear antigen and were im‐muno reactive with serum samples from HTLV‐ I‐ or HTLV‐Il‐ infected patients and with anti HTLV‐ I, p19 or p24 anti body. The provirus genome of HTLV‐II was detected in these cell lines by the polymerase chain reaction combined with a digoxigenin‐ enzyme‐ linked immunosorbent assay. Electron microscopy of CR‐IIA‐1 cells revealed a few im mature type C virus particles. These results suggest that HTLV‐ II was transmitted from the infected rabbit leukocyte cell line to human cord helper T lymphocytes with the development of immortalized HTLV ‐ II‐ pr

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02884.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A case of meningeal hamartoma of the scalp is reported. A 15‐year‐old girl was admitted complaining of scalp nodules in the midline occipital region. A midline skull defect was found under the nodular lesions. Histologically, the mass had a fibrocollagenous tract extending to the dura and showed an admixture of mature adipose tissue, small ves sels, strands of fibrocollagenous tissue, and scattered foci of meningocytes. lmmunohistochemically, the menin‐gocytes were positive for vimentin. Ultrastructurally, the meningocytes had scattered desmosomes, interdigitating processes, and intermediate filaments. The patient's brother also had the meningeal hamartoma of the scalp. Meningeal hamartoma as a variant of primary cutaneous meningioma is extremely rare, and this is the first report of such a case in Japan. Acta Pathol Jpn 42: 353–35

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02885.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A rare case of epithelial myoepithelial carcinoma of the parotid gland, which occurred in a child, is reported. An 8 year old boy presented with swelling of the right parotid gland. He underwent total parotidectomy followed by irradiation for a parotid gland tumor. Three years after the operation, a recurrent tumor invading the base of the skull and the brain and metastases in the lung were noted. The patient expired in spite of extirpation of the intracranial recurrent tumor. The resected tumor showed a character istic histologic feature:double ‐layered tubular structures composed of inner dark cells (epithelial cells) and outer clear cells (myoepithelial cells). This patient may be the youngest one with the epithelial‐myoepithelial carcinoma reported in the literature. Acta Pathol Jpn 42: 358–363,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02886.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A case of primary pulmonary mesenchymal chondrosar‐coma is reported. The tumor occurred first in the lower lobe of the right lung of a Japanese female aged 45. Three years after the first operation it metastasized to the upper lobe of the left lung. The tumors were highly cellular and composed of undifferentiated mesenchymal cells and inter spersed islands of well‐differentiated cartilaginous tissue. lmmunohistochemistry failed to detect S‐ 100 and vimentin in the undifferentiated cells. In contrast, Leu‐ 7 and blood coagulation factor Xllla were positive in these cells. Electron microscopically, undifferentiated mesenchymal cells had narrow cytoplasm with sparsity of organelles, but no intermediate‐sized filaments were detected. In the transitional areas between undifferentiated cells and cartilaginous components, thin intracytoplasmic filaments were sometimes observed in the tumor cells. The differ entiation toward cartilaginous cells of undifferentiated mesenchymal cells was suggested by immunohisto chemistry and electron microscopy. This is the first case of mesenchymal chondrosarcoma occurring in the lung with long‐ term follow‐ up. Acta Pathol Jpn 42:

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02887.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A 62‐ year‐ old woman with a complaint of abdominal dis‐tention underwent surgery to remove a tumor in her left ovary. The serum alpha‐ fetoprotein (AFP) level was 4,130 ng/ml. Histologically, the tumor was diagnosed as a mucinous cystadenocarcinoma with a small area of solid proliferation of tumor cells. The cells of the latter part were shown immunohistochemically to possess AFP. We suppose that a part of the mucinous cystadenocarcinoma dedifferentiates and produces AFP. Acta Pathol Jpn 42: 372–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb02888.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY