摘要:

Endometrial carcinoma was induced with a high incidence in various strains of mice and rats, by means of intrauterine application of 3‐methylcholanthrene under continuous estrogen stimulation. And a transplantation study of one of induced adenoacanthomas in A strain mice was successfully carried out.The endometrium in the early stage of the experiment showed atypical adenomatous hyperplasia that was soon followed by atypical adenomyosis. In the group of ICR mice treated with 0.8 mg of MCA, carcinomatous change was seen in atypical glands of the endometrium after the 14th week of the experiment. Carcinoma invasion and metastasis to visceral organs were found after 19 weeks.The majority of induced carcinomas of the endometrium were histo‐logically classified as either adenocarcinoma or adenoacanthoma, and only a few were regarded as squamous cell carcinoma. Ultrastructural study demonstrated that the cells in adenocarcinoma reveal poor cellular differentiation, while in adenoacanthoma the cells show better functional differentiation. The squamous cell component in adenoacanthoma is produced by squamous metaplasia of carcinoma cells.All induced sarcomas of the uterus were of myometrial smooth muscle cell origin, many of which, were accompanied by endometrial adenocarcinoma to be resulted in a form of carcinosarcoma.In an ICR mouse, sacrificed before uterine tumefaction, many extra‐as well as intracellular fine particles consistent with C‐type tumor viruses were detected in the myo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00117.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The antiatherosclerotic effects of pyridinolcarbamate and estrogen, both of which have a preventative effect against acute edematous vascular injury, were studied using 40 rabbits. Ten rabbits each received orally 0.1 mg/kg or 1 mg/kg of diethylstilbestrol, 10 mg/kg of pyridinolcarbamate or potato starch as a placebo. All were fed cholesterol for 15 weeks. Treatment with pyridinolcarbamate of 1 mg/kg of diethylstilbestrol was shown to exert a powerful effect in preventing the appearance of atheromatous changes (p<0.01) but 0.1 mg/kg of diethylstilbestrol did not show a preventative effect. The three treated groups exhibited protection against coronary atherosclerosis which was statistically significant when compared with the controls. Atheromas in rabbits treated with pyridinolcarbamate were characterized his‐tologically by the regeneration of smooth muscle fibers and those treated with diethylstilbestrol by fibrous healing. Necrotic foci or calcification was sometimes encountered, especially in the rabbits treated with 1 mg/kg of diethylstilbestrol. These preventative properties of the substances studied are possibly much related to inhibit permeability‐enhancing conditions of the arterial w

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00118.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

A histoenzymatic study was carried out to elucidate the anti‐atherosclerotic effect of estrogen and pyridinolcarbamate, which has been supposed to be much related to a permeability inhibiting effect.Cholesterol feeding of 15 weeks' regimen led the aortae of placebo control group to the condition of a definite reduction of glycolytic, SDH and ATPase activities, a fair reduction of 5'‐N and an increase of esterase, lipase, β‐gl and acid‐Pase activities as compared with those of regular diet group. Atheromatous lesions characterized with an accumulation of foamy cells and necrotic foci exhibited a strong acid‐Pase and β‐gl. activities and a weak reaction of lipase, esterase and glycolytic enzymes.However, in diethylstilbestrol treated and cholesterol‐fed rabbits, glycolytic, esterase, lipase, acid‐Pase and ATPase showed a more reducing activity than those of the control rabbits. A definite reduction of β‐gl, acid‐Pase and lipase, and an increase of 5'‐N activity were certified in the atheromatous lesions whose histological feature was characterized with a diffuse fibrosis.On the other hand, in the aortic wall of the rabbits treated with pyridinolcarbamate under cholesterol feeding the increase in the activities of PR, G‐6PDH, SDH and ATPase was certified. In atheromatous lesions the appearance or the increase of glycolytic enzyme and ATPase activities was especially characteristic. Other hydrolytic enzymes exhibited the same inclination of activity as those of estrogen treated group. These histoenzymatic characteristics of both substances may suggest a different way to anti‐atherosclerotic effect which is physiopa‐thologically regarded as permeability inhibiting effect and may possibly reflect in the difference of their effect or the repair p

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00119.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Electron microscopic study on pretibial myxedema lesions revealed that, mucin consisted of three types of substances: (1) filamentous to finely granular or amorphous substances, (2) spidery projections extending from a granular core, and (3) fine granules arranged in beaded form. In the lesions, there were numerous mesenchymal cells referred to as the M‐cells which were not found in the normal skin and seemed to be participating in the production and extrusion of the first type of substance and possibly the precursor substances of the other two composing mucin. Most of them were two to three times larger in size than ordinary mast cells. Their cytoplasm displayed, like that of goblet cell, many mitochondria, well developed rough and smooth endoplasmic reticulum, and prominent Golgi apparatus accompanied by various lysosomal structures.It might be supposed that the above precursor of the other two types of substances possibly excreted from M‐cells and the mast cell granules released from mast cells might correlate in the extracellular formation of the second and third types of substances. Ultrastructural similarities and dissimilarities between the M‐cell and other types of cells in the same lesions seemed to indicate that the M‐cell might be transformed from the mast cell or reticuloendothelial cell or fibroblast by metaplasia which might occur by the influence of hormonal disturbance of pretibial m

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00120.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

The bone marrow taken by either sternal or iliac crest aspiration of four cases of erythroleukemia was studied electron microscopically to reveal the following results.The erythroblast in erythroleukemia showed abnormalities both in the nucleus and cytoplasmic organelles, especially in the nucleolus and mitochondria. In two cases of erythroleukemia, unclassifiable blastic cells which were usually located near the sinus, were observed. Generally, the erythroblast has a few, high electron dense granules having no internal structure.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00121.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Rabbits were experimentally infected with Scbistosoma japonicum to observe morphological alterations of the liver to the 60th week of infection in chronological sequence. In the present report, the developing process of liver cirrhosis due to Schistosoma japonicum was elucidated together with the repairing process occurring after its cirrhotic state. It is concluded that the experimental liver cirrhosis due to Schistosoma japonicum is repairable. Consequently, in the persistence and progress of a cirrhotic state in the liver, repeated infections appear to play an important role.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00122.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Ultrastructural observation was carried out on neuroblastoma cells in a 4‐year‐old girl. The nuclei of these neoplastic cells were irregular with occasional cytoplasmic invaginations, and proportionally large with diffusely dispersed chromatin substance. Rare mitotic figures were also present. The cell‐to‐cell interfaces were relatively simple with only finely wavy membranes but without interdigitations. A few desmosomes were, however, apparent. The cytoplasmic pseudopodes were frequently observed in a limited area of the cell surface and nearly free of organelles. The main findings of the intracytoplasmic organelles consisted of some mitochondrial changes, poor development of Golgi bodies, occasional formation of focal cytoplasmic degradation, and intracytoplasmic Abrillar aggregates. Numerous large round to oval dense bodies encircled by a double membrane were highly suggestive of lipid bodies. The central area of rosette‐like cell aggregates was noted to be composed of cytoplasmic processes of neoplas

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00123.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Eight cases of retinoblastoma were histopathologically and in part, electron‐microscopically investigated. Their histological patterns were compared with those of human medulloblastoma and of the human retina during early fetal life.Five cases showed true rosettes (A‐group), but three cases did not (B‐group). A correlation was noted between the mode of growth and histopathological type of the tumors; in A‐group excepting one case, they showed only intraocular endophytic growth, while in B‐group, they extended extraocularly and were biologically more malignant. Among tumor cells of A‐group, atypism and pleomorphism were not so conspicuous as those in B‐group. It was indicated that a true rosette could be regarded as a histological manifestation of tumor differentiation, and its epithelial nature was disclosed by electron microscopy. Para‐rosettes, pseudo‐rosettes and perivascular rosettes, which were characteristic in B‐group, resembled human medulloblastoma and human retina during early fetal life in cell disposal pattern. Many findings indicated the retinoblastoma to be an immature ne

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00124.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Three cases of primary sarcoma of the gallbladder are reported. They consist of autopsy cases of leiomyoearcoma and rhabdomyosarcoma and surgery case of reticulum cell sarcoma, one of which was complicated with cholelithiasls.The number of sarcomas of the gallbladder reported in Japan adding our three cases totalled 14 cases, and 93 cases were reviewed from the world literature. The histological types, morphogenesis, relation to cholelithiasis, distribution of age and sex were discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00125.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

An autopsy case of a 52 years old male with primary osteogenic sarcoma arising in the cirrhotic liver was reported. A huge, yellowishgray, firm, multinodular tumor was found in the right lobe of the liver. Several small metastatic foci were noted in the right atrium and the small intestine. Microscopic examination revealed that the lesions showed polymorphic features but an essentially similar appearance as osteosarcoma originating in the skeleton.Primary sarcomas of the liver producing bone and/or cartilage as the essential component of the tumor are extremely rare. The nomenclature and histogenesis of such tumors were briefly discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1971.tb00126.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY