摘要:

The effect of a synthetic steroidal anti‐androgen, TZP‐4238, on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Old male beagle dogs (5–9 years old) were divided into three experimental groups. Group 1 consisted of BPH controls. Groups 2 and 3 received TZP‐4238 0.1 mg/kg/day and chlormadinone acetate (CMA) 0.3 mg/kg/day P.o., respectively, for 5 months. In group 1, glandular hyperplasia of the prostate was clearly detected. In contrast, TZP‐4238 (Group 2) or CMA (Group 3) produced marked atrophy of the glandular epithelium. In addition, a histopathological study showed that TZP‐4238 or CMA medication for 5 months exerted no effect on the testes and the pituitary luteinizing hormone (LH) cells. Therefore, it is suggested that TZP 4238 (0.1 mg/kg) or CMA (0.3 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes and pituitary LH cells. However, slightly decreased serum testosterone levels were found in TZP 4238 treated animals, due apparently to a direct and/or indirect effect on the testes. Thus, it is suggested that a marginal antigonadotrophic effect cannot be excluded. It is concluded that TZP‐4238 is a potent anti‐androgen for the treatment of spontaneous canine BPH, without any negative influence on the function of the testes and the pituitary LH cells. Acta Pathol Jpn 42

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01666.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The initial histological changes of leukemia were investigated in rats to which 1‐ethyl‐ 1‐nitrosourea and 1 butyl 1 nitrosourea were orally administered. The appearance of orthochromatic erythroblasts in the peripheral blood was used as the index of the initial stage of leukemia. The rat leukemia progressed from solitary lesions to scattered and further diffuse lesions. These leukemias are thought to begin as one, or only a few nodular foci, mainly in the bone marrow and partly in the spleen. Acta Pathol Jpn 42: 158–16

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01667.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Seven subclones derived from a chemically induced rat nephroblastoma cell line, ENUT, were isolated and their cytological characteristics were examined in order to investigate the biological nature of the parent tumor. The subclones were divisible into two types based on morphological and biological features: polygonal cells with well developed junctional complexes and less developed cell surface microvilli, showing a doubling time of 13.0 to 14.0 h and tumorigenicity in nude mice of 42 100%, and spindle ‐shaped cells with poorly developed junctional complexes and well developed microvilli, showing a doubling time of 9.7 to 12.2 h and 100% tumorigenicity. Potential for both spontaneous and experimental metastasis to the lungs was apparently higher in the spindle — shaped clones than in the polygonal clones. In spite of their differing characteristics, the cytochemical phenotypes of the two clonal types were almost identical to those of immature renal tubules of the developing fetal kidney. The present findings suggest that these subclones possess characteristics of early neph‐rogenic epithelial cells, and we speculate that the biological differences observed among the subclones may be explained by differences in malignant progression. In addition, these clones appear to be a useful model for the study of tumorigenicity and metastasis. Acta Pathol Jpn 42: 166–17

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01668.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A light and electron microscopy study was performed on endothelial cells of alveolar capillaries in biopsied lung tissues obtained from 28 patients with interstitial fibrotic lung diseases, including idiopathic pulmonary fibrosis, sar‐coidosis, hypersensitivity pneumonitis, chronic eosinophilic pneumonia, collagen vascular diseases and acute interstitial pneumonia. In the relatively early stages of acute interstitial pneumonia, hypersensitivity pneumonitis and other diseases, the cytoplasms of the endothelial cells appeared swollen and electron‐lucent and occasionally showed degeneration and necrosis. Although mitosis was not evident in the endothelium at any disease stage, some capillary endothelial cells showed regeneration. Furthermore, although rarely, they showed obvious phenotypic transformation into diaphragmed fenestrae in some limited segments of fibrotic lungs in the 20 of the 28 patients examined. The frequency of endothelial fenestration seemed to be correlated with the degree of interstitial fibrosis along the alveolar walls. In such fibrotic lung tissues, cuboidal metaplastic cells of bronchiolar origin proliferated on the luminal side. The mechanism of endothelial fenestration in the alveolar capillaries is assumed to be comparable with cuboidal metaplasia of alveolar epithelial cells. The alveolar capillary endothelium is recruited from the bronchiolar capillaries via bronchopul‐monary anastomoses unless endothelial repair occursin situ. Regenerating endothelial cells move into the alveolar capillary tubes along the remnant sleeves of the basement membrane. New endothelial processes finally display their original fenestrated structure while secreting irregular fragments of basement membrane during implantation in the capillary beds. Acta Pathol Jpn 42: 177– 18

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01669.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

In an attempt to reveal characteristic DNA ploidy patterns in primary renal tumors in children and adults, the nuclear DNA contents of 71 tumors were investigated. Nuclear DNA contents were measured by epifluorescence microscopy. The ploidy patterns of renal cell carcinomas (RCCs) and Wilms’tumors (WTs) were different. In RCCs there was no predominant DNA value, and aneuploidy indicated a poorer prognosis than diploidy. In contrast, a diploid pattern was predominant in WTs regardless of the prognosis. These results appear to reflect differences between adults and children in the mechanisms of tumorigenesis of renal tumors. Acta Pathol Jpn 42: 185–192, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01670.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Epithelial hyperplasia in the duct, ductule or lobule of the breast is a very common lesion and has been considered to carry a risk of subsequent invasive carcinoma. However, it is not known whether epithelial hyperplasia can transform into carcinoma or whether malignant change occursde novo. We analyzed the incidence of epithelial hyperplasia of the breast by making a comparison between cases of breast carcinoma and control autopsy specimens, and studied differences in the membrane antigens of the constituent cells using immunohistochemical staining of blood group antigens. It was found that the frequency of epithelial hyperplasia was higher in the cases of breast carcinoma. The lesions showed loss of A, B and H antigens at high frequency, and the proportion of lesions showing loss of these antigens became higher as the atypia of the lesion increased. On the other hand, expression of Leaantigen was observed more frequently in atypical epithelial hyperplasia orin situcarcinoma than in ordinary epithelial hyperplasia. These findings suggest possible transformation from epithelial hyperplasia to carcinoma, and indicate that atypical epithelial hyperplasia may be precancerous in nature. Acta Pathol Jpn 42: 193–200, 199

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01671.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We describe the first recorded case of segmental mediolytic arteritis (SMA) in Japan. A 71‐year‐old Japanese woman developed sudden abdominal pain and went into shock during hospitalization for treatment of valvular heart disease. Laparotomy revealed a ruptured pseudoaneurysm of the left gastric artery. Histological examination of the resected artery revealed multiple extensive areas of the dilated wall where the media had partially or totally disappeared with or without the intima. These features were typical of those described previously for SMA (1, 2). Three dimensional analysis of the arterial lesions revealed that the residual media formed branches and cavities down the long axis of the artery, indicating that the major cause of the medial disappearance was arterial dissection. Three months later, the patient died of sepsis. Autopsy revealed pseudoaneurysm formation at three different locations in the splenic artery. Histologically, these pseudoaneurysms showed destructive changes in the arterial wall similar to those described above, with organization and thrombosis, and were considered to be the end stage lesion of SMA. This case is considered to be the fifth adult case of SMA in the literature and the first one showing chronic changes. Acta Pathol Jpn 42: 201–209,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01672.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A case of localized primary amyloid tumor of the thyroid gland developing in the course of Hashimoto's thyroiditis was studied using histochemistry, immunohistochemistry and electron microscopy. The patient was diagnosed as having Hashimoto's thyroiditis by histological examination of the thyroid and by the presence of a high titer of serum thyroglobulin and thyroid microsomal antibodies. In addition, the thyroid gland exhibited multiple nodular deposits of amyloid which were resistant to prior incubation with potassium permanganate. The amyloid deposits were surrounded by numerous histiocytes and multinucleated giant cells which contained small amyloid droplets in their cytoplasm. However, no amyloid deposits were observed in the walls of blood vessels. lmmunohistochemistry showed that the amyloid was strongly positive for amyloid P component, IgG and kappa light chains. Ultrastructurally, the amyloid was composed of straight fibrils with a diameter of 7 to 10 nm. Histiocytes extended slender cytoplasmic processes in a radial fashion into amyloid fibrils, which exhibited a highly organized star‐like pattern. This was considered to be an extremely rare case of localized primary amyloidosis of the thyroid, in which IgG, especially kappa light chains (AL), was present as a precursor protein. Acta Pathol Jpn 42: 210–216. 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01673.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The first case of benign fibrous histiocytoma of the renal capsule is reported in a male aged 44 years. The tumor had its point of origin in the renal capsule. Histologically, the tumor was composed of intersecting fascicles of fibro‐blastic cells forming a loose crisscross or “storiform” pattern. Electron microscopic studies of tumor cells revealed intermediate filaments and membrane‐bound collagen fibers which continued to extracellular collagen bundles. This deep‐seated fibrous histiocytoma had a more prominent storiform pattern and fewer secondary elements such as xanthoma cells than cutaneous ones. Acta Pathol Jpn 42: 217

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01674.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report myelolipoma found in two patients, of whom one had hormonal abnormalities related to adrenal function. The first patient was a 36 year‐old woman, who was found incidentally to have a left adrenal tumor by CT scan during admission for treatment of Guillain Barre syndrome. Obesity, hirsutism and osteoporosis were also evident, and the patient was forwarded for additional endocrine function analysis, which revealed elevation of serum cortisol, urine 17 OHCS and 17 KS, and a decreased level of ACTH. These abnormalities returned to normal after excision of the tumor. Pathologically, the tumor was composed of mature fat cells and hematopoietic components, and was diagnosed as myelolipoma. The second patient was a 63 year‐old woman, who was receiving follow‐up care for hyperthyroidism. A right adrenal tumor was noted incidentally in a routine examination by CT scan. Endo‐crinologically, she was found to have no abnormalities of adrenal function. The tumor was excised, and diagnosed pathologically as myelolipoma, being composed of mature fat cells and hematopoietic components. Generally, although most rnyelolipomas have no endocrine function, our first patient showed features of Cushing's syndrome. Thus it is suggested that an interrelationship may exist between myelolipoma and endocrinological alteration. Acta Pathol Jpn 42: 221 22

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb01675.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY