摘要:

The adequate appraisal of precancerous changes is of the utmost importance in our everlasting fight against cancer, and its socio–rnedical relevance is acknowledged world–wide. In every country where epidemiologists register a rising incidence of malignant neoplasms, endeavours must focus not only on the early diagnosis of existing cancers, but even more on detecting the signs of coming tumors. That is why today the precancerous lesions are a main point of interest in cancer research all over the world for pathologists, radiologists, surgeons, obstetricians, etc. ACTA PATHOL. JPN. 33: 195–217,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01411.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Human renal biopsy specimens (472 cases) from varied kidney diseases, especially minimal glomerular change group and other idiopathic glomerular diseases having nephrotic manifestation of mainly juvenile individuals, showed morphologic evidence of paraarterial deposits of afferent arterioles at the glomerular entrances in more than 50% of examined cases. Because these deposits were often accompanied with concomitant mesangial, intraarterial and subendothelial deposits of afferent arterioles, it was felt that retarded mesangial transport which is ordinarily associated with certain glomerular diseases might be an important factor to produce these particular paraarterial deposits. The referred deposits of minimal glomerular change group cases were thought to predispose the occurrence of focal sclerotic capillary lesions at the vascular poles of glomeruli. The experimental chronic nephrotic rats produced by daily administration of aminonucleoside of puromycin revealed mesangial dysfunction with increased uptake and retarded disposal of secondarily overloaded aggregated human gamma globulin at mesangial areas in glomeruli. Besides, the increased deposits of autologous serum proteins in mesangial areas and arteriolar walls were common findings in those rats, and these deposits were observed to be always preceded to the occurrence of segmental sclerotic changes of glomeruli, which were often associated in the later stage of this experiment. ACTA PATHOL. JPN. 33: 219∼236, 198

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01412.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Proliferative activity of possible preneoplastic cells (subependymal cells and glioblasts), early neoplastic cells and glioma cells induced by transplacental ethylnitrosourea (ENU) treatment in the rat was analysed by historadioautography and electron microscopy. Labeling index of2H–thymidine in subependymal cells was the highest in the cerebrum of postnatal age, but no difference was observed between the normal and ENU treated groups. Thus, preneoplastic cells could not be distinguished from normal cells by morphology and proliferative activity. Focus of early neoplastic proliferation was composed of rather heterogenous and less differentiated cells, such as oligodendroblast–, glioblast– and subependymal cell–like cells, and preferentially located around the periventricular areas. Labeling index of early neoplastic proliferation was very low although the value gradually increased with age. Proliferative activity of glioma cells was higher than that of the early neoplastic cells and lower than subependymal cells, and further differed according to the degree of differentiation and morphological type. Finally, it is suggested that glioma might develop mainly through the differentiation from the focus of early neoplastic proliferation. ACTA PATHOL. JPN. 33: 237–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01413.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Four cases of Ischemic enterocolitis without arterio–occlusive lesion were described. Three cases were associated with sigmoid colon carcinomas. Ischemic lesions developed anal to the carcinomas in two cases, and oral to sigmoidostomy to relieve intestinal obstruction by carcinoma in one case. One other case was associated with inguinal hernia. Grossly, ischemic lesions involved relatively short intestinal segments, and the ischemic colonic lesions were not related to teniae coli. Extensive veno–occlusive lesions were discovered in a case of ischemic stricture of the ileum, which had been incarcerated in the right inguinal hernia. Reversible mechanical occlusion of the intestinal vessels caused by transient or recurrent intestinal strangulation is the most probable cause of these ischemic lesions., ACTA PATHOL. JPN. 33: 249–256,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01414.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Four cases of chronic annular ulcers of the stagnant ileum were described, The ulcers developed at the necks of the distended oral blind loops formed by side–to–side intestinal anastomoses in 3 cases and orally to the site of ileal stenosis by a congenital mesodiverticular band in one case. All ulcers were shallow and characterized by desmoplastic reaction and extensive veno–occlusive lesions. Arterio–occlusive lesions were sparse except for the youngest case. Intestinal ischemia caused by transient or recurrent ileal intussusception is the possible cause of these ulcers. ACTA PATHOL. JPN. 33: 257–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01415.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Single and repeated restrained stresses in rats were conducted as a model for evaluating sequential changes of gastric submucosal arteries evoked by stressful stimuli with an emphasis on medial alterations. By single restrained stress, three distinct acute changes of the media were found after a short time of the stress–withdrawal; (1) focal cytoplasmic necrosis, (2) fibrin in–sudation, and (3) leukocyte migration. These acute lesions were readily healed within 20 days without cellular increase or fibrous thickening of the intima. When the stress was repeated over a long period of time, medial smooth muscle cells showed marked degenerative changes (“atrophy with moth–eaten structure”) with an increase of granular cell debris and basement membranelike materials. The results suggest that angiopathic effects of stresses may be attributed to the unsuited responsiveness of small artery to vasospasm and its sequential hemodynamic derangements. ACTA PATHOL. JPN. 33: 265

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01416.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Human thymuses, ranging in age from newborn to 62 years old, were studied enzyme histochemically. The thymic epithelial cells covering cortical surface and bordering vascular areas in the medulla were positive for 5′–nucleotidase, but not for other enzymes. The thymic epithelial cells composing Hassall's corpuscles were positive for acid phosphatase, esterases, –glucuronidase, and alkaline phosphatase, regardless of age, but totally negative for 5′–nucleotidase and ATPase. All enzymes examined except for glucuronidase were demonstrated income of the thymie epithelial cells scattered in the medulla, although the pattern of distribution and the degree of positivity were different by enzymes. These findings suggest that the thymic epithelial cells are composed of functionally heterogenous subpopula–tions. Acid phosphatase was demonstrated in thymocytes in both cortex and medulla, but 5′–nucleotidase and ATPase were observed in some thymocytes in the medulla of young thymus. ACTA PATHOL. JPN. 33

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01417.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A total of 164 gastric carcinomas comprising 97 advanced cancers and 67 early cancers were examined immunohistochemically for human chorionic gonadotropin (hCG). Tumor cells containing immunoreactive hCG was found in 7 cases or 10.4% of the early cancer cases and in 11 cases or 11.3% of the advanced cancer cases. Moreover, the incidence of hCG–beta subunit positive cells was 8.2% in the advanced cancer cases and 6.0% in the early cancer cases. The incidence of these cells didjnotjdiffer significantly by histological type and by infiltrative growth of gastric carcinoma. However, hCG–containing tumor cells were frequently detected in poorly differentiated or undifferentiated area within the tumor, fa addition, these cells did not contain mucin or argyrophil granules. The three year survival rates indicated a tendency for advanced gastric cancer containing hCG to have a poor prognosis. ACTA PATHOL. JPN. 33: 287–296,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01418.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

To Investigate morphological features of the human pancreatic ductal system, light and electron microscopic studies were performed, on the comparative basis with those of several species of mammals. The human pancreas possessed relatively well–developed ductal system, as compared with those of other mammals. Furthermore, it had unique centroacinr cells containing numerous mitochondria. The mode of innervation to the ducts, and cytological features such as cilia formation and mucin production were also revealed. Several kinds of endocrine cells including A, B, D1, ECn, presumptive EC1, and presumptive EC2or K could be identified, but a few remained unclassiflable. The above findings are considered to be prerequisite for understanding the physiology, especially of bicarbonate production, and pathology, especially of oncogenesis of the exocrine and endocrine pancreas. ACTA PATHOL. JPN. 33: 297–321, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01419.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Renal vascular changes In severe hypertension were studied. Twenty–five cases selected from 4,629 autopsies were classified into 2 groups according to the cause of death: group 1 (9 cases died of renal failure) and group 2 (16 cases of extra–renal death). Group 1 had been clinically diagnosed as malignant hypertension and had the hallmarks of malignant nephrosclerosis characterized by arteriolar fibrinoid necrosis and edematous intimal thickening. Group 2 had been clinically diagnosed as benign hypertension and basically exhibited the changes of benign nephrosclerosis. However, about half of the cases of group 2 had arteriolar fibrinoid necrosis, though the lesion was usually less extensive than in group 1. Immunofluorescence revealed similar deposits of immunoglobulins and fibrinogen in the site of fibrinoid necrosis observed in both groups. As for the changes of interlobular arteries, a quantitative analysis disclosed a distinctive difference between groups 1 and 2 with respect to the narrowing ratio of arterial lumina, though edematous intimal thickening was recognized on relatively rare occasions in the distal interlobular arteries to a few cases of group 2. From the results, the problem of transition from the benign to malignant nephrosclerosis was discussed. ACTA PATHOL. JPN. 33: 323–331,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb01420.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY