摘要:

The vascular structures in the lymph node and their relation to fluid exchange have been reported in previous communications and it was considered that the morphological changes of the vascular structures were closely correlated with the functional development of lymph nodes as an antibody forming organ. In order to clarify the localization of the given antigen and newly formed antibody in relation to the morphological structure of lymph nodes, the popliteal lymph nodes of rabbits were studied by immuno‐fluorescent techniques.The antibody was found in the pavement arrangement (solid) of reticulum tissue which was formed by the expel of lymphocytes in the cortical mass and by the morphofunctional alterations of the reticulum cells. The given antigen and newly formed antibody were never detected in the follicles throughout the period of this experiment. ACTA PATH. JAP. 22:427–440, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01842.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The morphological changes of the mesenterial arteries of guinea pig were studied with the administration of intravascular or intraperitoneal injection of soluble immune complexes. The main change consisted of vacuolar alteration of arterial endothelium. This was considered to have been caused by a regurgitation mechanism of the exudated plasma across the arterial wall and is the initial morphologic change of so‐called allergic vasculitis. ACTA PATH. JAP. 22:441–455, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01843.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

This report is concerned with the studies on the changes of the intimal elastic lamella and the intermuscular matrix with the administration of hyaluronidase which is thought to have the enzymatic activities for the decrease of the viscosity of acid mucopolysaccharide by way of depolymerlsation. With the administration of hyaluronidase, the remarkable morphological changes of Internal elastic lamella and the intercellular matrix of the large vein were demonstrated. ACTA PATH. JAP. 22:457–464, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01844.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Delayed hypersensitivity reaction is characterized by Infiltration of mononuclear cells (macrophages and lymphocytes). The mechanisms of emigration and function of mononuclear cells in local skin lesions were studied in experimental tuberculosis. A chemotactlc activity for mononuclear cells was found in the extract of tuberculin skin sites, and proteases active at pH 3, 6, and 9 were found in the extract and partially purified using ammonium sulfate and column chromatography. Relationship between chemotactlc activity and protease activities was discussed. Similar protease activities were found in the extract of sensitized lymph node cells, and proteases active at pH 6 and 9 were increased when homo‐genate of sensitized lymph node cells was Incubated with PPD for 3 hours at 37°C. It appears that PPD could concern to release protease from sensitized lymphocytes and involve in delayed hypersensitivity reactions. The role of mononuclear cells in tuberculous skin lesions were studied in the sense of bacteriocidal activity for tubercle bacilli. Certain macrophages in the skin lesions were produced locally by cell division. Macrophages in granulation tissue around necrotic foci were specifically matured and strongly active for/9‐galactosidase, and the number of acid fast bacilli in macrophages and the intensity of staining for /3‐galactosidase were reversely correlated. This was also confirmed in irradiated rabbits with 400 rads of whole body radiation. These findings suggest that high levels of lysosomal enzymes are involved in destruction of b

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01845.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The Initial changes of leukemia were examined in rats which were fed 2,7‐diacetylaminofluorene. The appearance of erythroblasts in the peripheral blood was employed as an index of the initial stage of leukemia. Histological examination of the bone marrows revealed one or two nodular foci of leukemic cells at the early stage of the appearance of erythroblasts. The leukemia in rats which were fed 2,7‐diacetylaminofluorene was considered to begin as one or two nodular foci in the bone mar

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01846.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The pathological findings In four infants with chronic myeloid leukemia (GML) of the juvenile type were compared with those in adults with GML. In three cases Hb‐F of erythrocytes was positive and Ph1chromosome was negative. In one case these examinations were not performed.The bone marrow shows a wide range of maturation of granulocytes in both types. Immature forms, however, are more abundant in the juvenile type than in the adult type. Advanced structural alteration as splenoid marrow is rare in the juvenile type. Decrease of megakaryocytes is more profound than that of erythroblasts. Involvement of lymph node and lymphatic apparatus is much more extensive in the juvenile type than in the adult type. Proliferation of erythroblasts is prominent in foci of extramedullary infiltration, frequently showing a nodular pattern.For examination of Hb‐F of erythrocytes in formol‐flxed paraffin sections, alkali denaturatlon followed by spectrophotometry with UMSP‐I was applied. The denaturatlon rate of erythrocytes In the liver is lower In the juvenile type of GML than in the control adults and adult type of CML. ACTA PATH. JAP. 22:489–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01847.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The peripheral blood of four patients with acute myelogenous leukemia was used to study the relationship between the granules and the Auer bodies. Electron microscopic observation revealed the picture of fusion of these organelles. Pictures such as an unusually developed granule with changed internal structure, and the developmental process of the Auer body were observed. It was concluded that the origin of the Auer body was a granule, as previously reported, and they were classified into three types according to their different internal structures. No particular relation between the size of the granule and the degree of electron density was noticed, though some authors Indicated that the size of the granule was related to the electron density. Several microtubules with diameter of 60 A which run parallel to each other were frequently seen In the granules. It was not clarified as to what kind of granule corresponded to the azur granule in this study. ACTA PATH. JAP. 22:509–515, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01848.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Drug‐Induced generalized phosphollpldosis in human beings is described. Detailed study of phospholipid fatty liver, which was first reported by us in 1968, disclosed that phospholipid accumulation is not only found in the liver but is also distributed throughout the body. From clinical as well as experimental survey, it may be concluded that this phospholipido‐sls was caused by administration of 4.4′‐diethylamlnoethoxy hexestrol. Three autopsy cases showed liver cirrhosis of a peculiar form, such as fine granular thln‐septal cirrhosis with phospholipid deposition and alcoholic hyalines. This septal cirrhosis may have resulted from phospholipid deposition. The relationship between alcoholic hyaline and lipid metabolism is discussed. ACTA PATH. JAP. 22: 517

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01849.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Carcinoid tumors arising in mucosa of respiratory and alimentary tracts were found to form a distinct group with characteristic endocrine function in relationship to their site of origin. These include ACTH‐secretlng bronchial carcinoid, histamine‐producing gastric carcinoid, and serotonin‐producing ileal and appendiceal carcinoid. It is also conceivable that the carcinoid‐islet cell tumor of duodenum and the rectal carcinoid may constitute other groups of the carcinoid tumor, though the humoral substances produced by these tumor groups have not yet been identified. On the basis of morphologic and metabolic features of the carcinoid tumors occurring in different sites, it is proposed that the carcinoid tumor is derived from the neuroendocrine cells which embryo‐logically migrate into the primitive alimentary tract mucosa and mature Into the endocrine cells with unique metabolic function in the final resting site of the respective organs. ACTA PATH. JAP. 22:533

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01850.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A case of argyrophil cell, B type, carcinoid of the stomach In a 36‐year‐old male is presented. The patient had no special clinical manifestations as to carcinoid syndrome, and the biochemical analysis on the preoperative urine and blood and on the tumor tissue itself failed to disclose significant increase in either active or end products of corresponding amines. Diagnosis was based merely on morphological findings including those of silver impregnations of both argentaffin and argyrophil reactions and electron‐microscopic demonstration of the specific secretory granules. The importance of preoperative diagnosis by all possible means on cases such as ours is our special emphasis in order to obtain correlative analysis of silver reactions and biochemistry along with electron‐microscopy. ACTA PATH. JAP. 22:541–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1972.tb01851.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY