摘要:

The oral administration of N,N'‐2,7‐fluorenylenebisacetamide induced leukemia, especially mature granulocytic leukemia, in rats. The peripheral blood was examined on various schedules, once or twice a week for a long term. The blood volume lost by a blood collection was little, but It was not negligible in small animals such as rats when the loss was repeated. We investigated the relationship between the volume of blood loss and the incidence of leukemia. The incidence of leukemia rose as the volume of blood loss increased. There was a positive correlation between them. The induction of mature granulocytic leukemia was thought to be increased by the promotion of the granulopoiesis which had been supressed by 2,7‐FAA. It was concluded that the blood loss by repeated blood collection for examination raised the Incidence of 2,7‐FAA induced l

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00870.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The role of coagulation and fibrinolysis in the pathogenesis of rabbit Masugi nephritis was studied. Fibrinolytic activity of urine decreased rapidly to the minimum values at the peak of the disease. Histologic observations showed a severe proliferative glomerulonephritis. Immunofluorescent studies revealed localization of rabbit gamma globulin along the glomerular basement membrane in a typical linear pattern. Fibrin was positive in glomeruli not only within fibrinoid deposits, but also often diffusely In the places where no obvious fibrin was detected in histologic sections. Bright strands of fibrin was present between the cells forming a crescent. Electron microscopy indicated accumulation of fibrinoid materials beneath the endothelium. The basement membrane was damaged by the deposition of fibrinoid and followed by massive escape of intracaplllary contents into the Bowman's space. Abundant fibrin and fibrinoid were seen in newly formed “monocytlceplthelial” crescents. Todd's fibrinolysis autography revealed diminished fibrinolytic activity in the severely affected glomeruli. Treatment with heparin prevented crescent formation and glomerular disorganization, while treatment with t‐AMGHA Increased fibrin and fibrinoid deposition and aggravated the glomerular injuries. It was concluded that the coagulation‐fibrinolysis system could play an Important role in the course of rabbit Masugi ne

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00871.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In addition to a light‐microscopical and histochemical investigation of primary and metastatic lesions in 27 cases of Ewing's sarcoma, biopsy materials from the primary bone lesions of 7 patients with this neoplasm were examined histochemically, enzyme ‐cytochemically and electron microscopically to elucidate the histogenesis and nature of the neoplasm. Ultrastructural observation has revealed that besides intracytoplasmic and extracellular deposition of glycogen the tumor cells possess several cytological features characterized by intracytoplasmic microfilaments of varying thickness up to 80 Å, occasional appearance of dense patches, fat droplets, desmosomal connections and reminiscent attachment bodies. The tumor cells are mostly round, oval or polygonal in shape, but spindle or elongated cells are intermingled and occasionally contain well‐developed rough endoplasmic reticulum, resembling pericytes or fibroblasts. In the intercellular spaces amongst the tumor cells, varying amounts of variable‐shaped amorphous materials are found, which are compatible with acid mucopolysaccharides and glycoproteins histochemically verified. These findings may suggest that Ewing's sarcoma is a highly malignant neoplasm originating from a transitional cell developed from pericytes to vascular smooth msucle cells in the bon

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00872.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The ultrastructure of “non‐pathologic” human pituitary gland obtained from eight cases at autopsy, who received no hormonal therapy and who revealed no significant changes in the pituitary and its target organs, was investigated in an attempt to identify human adenohypophyseal cells by comparing their secretory granules with those of experimental animals. Besides the follicular cell, Ave different granulated cell types were distinguished The Type I cell contained abundant, dense secretory granules (350–500 mμ across). The Type II cell was characterized by dense granules, which were the largest in size (500–700 mμ across) and the most irregular in shape. Granules of the Type III cell were less characteristic (200–300 m/t) across). The Type IV cell contained dense granules, which were the smallest in size (100–150mμacross) and were characteristically arranged along the plasma membrane. The Type V cell was characterized by the presence of small, haloed granules (100–200 mμ across). The cells of these five types could presumably be the somatotroph, lactotroph, gonadotroph, thyrotroph and cortico

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00873.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The right lungs of Sprague‐Dauley rats were irradiated with single doses of 1000 r, 2000 r or 3000 r to Induce radiation pneumonitis and diffuse fibrosis, and the alkaline and acid phosphatase (Al‐Pase, Ac‐Pase) activities of the lungs were observed histochemically. Only the lungs irradiated with 3000 r steadily exhibited sequential changes leading to radiation pneumonitis and subsequent diffuse fibrosis, whereas the lungs irradiated with 2000 r developed only some degree of radiation pneumonitis. Alveolar capillary endothelia in the lesion of pulmonary fibrosis exhibited an intense activity of Al‐Pase, while the endothelia in all the other experimental conditions did not show this activity. Alveolar macrophages increased their sizes and the activity of Ac‐Pase after the irradiation. In the later stages, large foamy macrophages with thin diffuse deposits of the reaction products became predominant. These macrophages never exhibited Al‐Pase activity. Type II alveolar epithelial cells showed an intense Al‐Pase activity on their microvilli, and their Ac‐Pase activity was negligible in non‐irradiated lungs. Bizarre cells, appearing at the stage of radiation pneumonitis, showed an intense Al‐Pase activity on their cell membranes and a weak and diffuse Ac‐Pase activity in their cytoplasms. Septal cells achieved the Al‐Pase activity 3 or 4 weeks after the irradiation when mast cells were not yet see

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00874.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The incidence of primay adenoacanthoma of the stomach is extremely low. In the Sasebo City Hospital, there were only two autopsy cases of adenoacanthoma among 46 cases of gastric cancer during the past four years. The first case was a 45 year‐old male with adenoacanthoma. The second case was a49 year‐old female with metachronous triple cancers; adenoacanthoma of the stomach, squamous cell carcinoma of the uterus and squamous cell carcinoma of the tongue. Histological examination showed muconodular adenocarcinoma of the stomach at the time of first operation and adenoacanthoma at the time of autopsy. These two cases suggest that adenoacanthomas of the stomach may originate from squamous metaplasia or squamous differentiation of a preexisting glandular carcin

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00875.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An autopsy case of mesenchymal hamartoma of the liver was reported and from the macroscoplcal observation and serial sections of the tumor the following findings were found: (1) macroscopically the tumor is supplied by only one large triad, (2) in the tumor hepatic lobular structure is fundamentally preserved and proliferated bile ducts with surrounding fibrosis and many bile thrombi are mainly elongated and dilated Hering's canals, (3) the cysts connect with dilated interlobular bile ducts, (4) there are two portions, where connection of bile ducts is incomplete, that Is, from Hering's canals to interlobular bile ducts and from interlobular ducts to large ducts in the large triad of (1), (5) almost all portal veins in the large triad of (2) are stenosed or obliterated by loose intimal fibrosis. From these findings it is considered that intrahepatic bile duct obstruction resulting in regional biliary cirrhosis is the fundamental process of this disease, and in addition the role of hemodynamic disturbance was discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00876.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

This is a case report of a 35‐year‐old female who showed a relatively short clinical course of severe liver cirrhosis and proteinuria. On light microscopical studies of autopsy material, besides active postnecrotic type liver cirrhosis, typical membranous glomerulonephritis was found. Immunofluorescent study disclosed not only clustered HBsAg (hepatitis type B surface antigen) in occasional hepatic cells but also beaded granular type deposition of HBsAg, IgG, IgM, IgA and complement Gsalong renal glomerular basement membrane (GBM). Electron microscopical study disclosed multiple particulated material in occasional inclusion bodies of hepatic cells and in subepithelial and subendothelial dense deposits along the GBM. Enzymatic immunoelectron microscopical study confirmed these particles especially along the GBM being HBsAg themselves. It was concluded that HBsAg‐Ab (antibody) complex was the pathogenetic factor responsible for the glomerular change of this particular case. Although HBsAg and Ab were examined to be negative in serum throughout the patient's clinical course, the possibility of the presence of circulating HBsAg‐Ab complex in serum was di

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00877.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A report was made on an autopsy case of myositis ossificans progressiva in a girl who died at the age of 8 years and 11 months. The first symptom appeared as right wryneck ten days after birth. Parathyroid hyperplasia and polycystic ovary with high level of serum parathyroid hormone, FSH and LH were confirmed at autopsy. Parathyroid hyperactivity might be a secondary response to the continuous stimulation by increased peripheral consumption of calcium ions due to relentlessly progressive ossification in fibrous connective tissue.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00878.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

On 58 cases of D1trisomy, which were classified as those with seven separate D chromosomes, including the one in this report, congenital brain and facial anomalies were reviewed and discussed. Congenital brain defects in this syndrome might be classified into three groups: (I) grossly normal brain, (II) absence of olfactory bulbi and tracts, but normally‐separated cerebral hemisphere, and (III) completely or {incompletely uncleaved hemispheres with absence of olfactory bulbi and tracts. 25.9% of the cases were found in group I, 56.9% in group II, and 17.2% in group III, respectively. Although facial anomalies predicted the brain defects in group III, malformations of the face were not concerned with the brain defects in group I and II. There were no cases with both, normal brain and fac

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00879.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY