摘要:

Clinicopathologic, enzyme histochemical and electron microscopic findings in 52 patients with pigmented villonodular synovitis (PVS) are reported. The lesion was by far the most common in the knee joint (48%), followed by the ankle joint (25%). As to sex incidence, there seemed to be no predilection (46% in men, 54% in women). Microscopically, the PVS showed thin or thick villous projections of the involved synovial membrane, associated with or without nodular formation. The nodule of PVS consisted essentially of a proliferation of histiocyte‐like cells with phagocytic activities. Another characteristic feature was large clefts and pseudoglandular or alveolar spaces lined by synovial cells. Enzyme histochemical studies revealed that the lesional cells had functional properties of macrophages. Electron microscopically, the lesion consisted essentially of histiocyte‐like and flbroblast‐like cells, together with intermediate cells and myofibrob

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01022.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Fourteen cases of inflammatory fibroid polyp of the stomach were studied in terms of immunohistochemistry and ultrastructure. They occurred as polypoid lesions in the antrum, except for two found in the body of the stomach. Out of the 14 cases, two were found to be multiple and the remainder solitary. In all but one lesion, the mucosal layer was involved and six lesions were entirely localized within the mucosal layer, suggesting that inflammatory fibroid polyps of the stomach originate in the mucosal layer. Neither S100 protein, factor VII‐related antigen, alpha 1‐antitrypsin nor lysozymes were found in the cytoplasm of the proliferating cells. The ultrastructures of the proliferating cells were fibroblastic rather than neurogenic, angiogenic, or myofibroblastic. These findings suggest that the cells are fibroblasts, though the possibility that they are facultative fibroblasts remains. An interesting observation made with electron microscope was the infection of micro‐organisms similar to mycoplasma. This seems to deserve further investigation as a possible etiologic factor of the di

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01023.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Of 683 cases of primary epithelial tumors arising in the parotid gland, 20 cases could be defined as adenocarcinomas, constituting 2.9% of the total number or 10.0% of 201 malignant tumors. These adenocarcinomas were characterized by a marked diversity in the histologic manifestations, presenting tubular, papillary, pseudoadenoid cystic, cribriform, trabecular, sarcomatoid, and other patterns. Basically, however, they could be classified into two major subtypes, i.e., tubular and papillary variants on the basis of their predominant histological patterns. The tumor cells showed a distinctive sign of high grade malignancy such as the occurrence of many mitotic figures and involvements of lymphatic vessels and/or blood vessels. Ultrastructurally, the tumor cells consisted of two basic varieties, resembling myoepithelial cells and duct epithelium. It is thus suggested that immature tumor cells could differentiate into a structure mimicking an intercalated duct. Clinicopathologically, the tumors were seen with a higher frequency in middle‐aged males (average 44 years of age

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01024.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Twelve autopsied cases with adult T‐cell leukemia (ATL) were reviewed clinicopathologically. The prognosis of three cases who had suffered from severe cutaneous lesions was much better than that of the other nine cases with no or negligible cutaneous lesions. The surface marker of leukemic cells from six cases was ordinary inducer/helper phenotype (OKT4+ and 8‐), but in one case leukemic cells showed OKT4+ and 8+. In another case, a significant amount of leukemic cell infiltration was found in the thymic cortex. Calcium content in the bone of ATL cases was lower than that of the patients without ATL (control group), and six cases with ATL (50%) were complicated by severe hypercalcemia. Neither adenoma nor hyperplasia of the parathyroid glands was found in any case. In most severely hypercalcemic patients, bone trabeculae were actively absorbed by numerous osteoclasts and partly replaced by fibrous tissues. In two normocalcemic patients, skeletal calcium content was also markedly reduced by osteoporosis, but the activation of osteoclasts was inconspicuous. It was speculated that the manner of bone resorption in ATL cases was diverse and there were some clinicopathological subtypes in ATL from the viewpoints of cutaneous lesions, hypercalcemia, and bone lesi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01025.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

A clinicopathological study was undertaken in 15 cases of massive hepatic necrosis after shock. The GOT and GPT level exceeded 1000 units in 10 cases. The 15 cases consisted of 3 diagnosed as fulminant hepatitis clinically and 12 diagnosed as disseminated intravascular coagulation (DIC) or multiple systemic organ failure (MOF) from the unremarkableness of liver dysfunction. It was noteworthy that sepsis and surgery were closely associated with these lesions. The weight of the liver at autopsy ranged from 800 to 2,700 g. Liver necrosis was macroscopically characterized by clear demarcation of the necrotic areas sharply separated from the surrounding liver parenchyma, showing the appearance of so‐called “map‐like necrosis”. Microscopically, the lesions in these subjects showed mainly the pattern of centrilobular necrosis. As observed in the burn shock case (case 12), the shock which provoked in different phases of time seemed to have repeated its attack. These liver necroses were considered to result from severe systemic circulatory disturbance or intrahepatic circulatory disturbance. The possibility is indicated that the generalized or univisceral Shwartzman reaction, and repeated and combined severe shock participated in the pathogenesis. Fibrin thrombi aggrevate tissue perfusion and accelerate anoxia. Heparin therapy seemed effective in these cases if administered at an appropria

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01026.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Changes of hepatic microcirculations in 22 autopsy cases of liver cirrhosis were analyzed by corrosion cast/scanning electron microscope (SEM) examination. By this method, the site of arterioportal (A‐P) communication in liver cirrhosis was clearly demonstrated between proliferated portal venules and arterial capillaries. The communications were observed at the same site as in the normal liver and were not at larger arterial and portal vein branches. The findings indicate that the increase of A‐P communication in liver cirrhosis may be called “capillary shunting”. On the basis of the findings, it was postulated that the A‐P shunt could not assist in the development of portal hypertension by the transmission of high arterial pressure to the portal vein but could only compensate for decreased portal flow and/or elevate the oxygen concentration in the sinusoids to improve the hypoxic state of the liver parenchyma. It was also demonstrated that the arterial capillarization of the interstitial septa in micronodular wide septal cirrhosis was more prominent than that in macronodular thin septal cirrhosis. A grade of portal vein reduction and compensatory arterialization in a fibrous septum have been regarded as an index to estimate the advancement of liver cirrhosis. Therefere, if alcoholic micronodular cirrhosis could change into macronodular, the process should have occurred at least before the establishment of micronodular wide septal

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01027.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

The purpose of this study was to examine the effects of actinomycin D on localization of acridine orange (AO) binding to DNA in rat astrocytoma C6 cells and to discuss briefly the significance of AO chromatin interaction products. Actinomycin D markedly inhibited 3H‐uridine incorporation into RNA and the percentage of AO positive cells was reduced to approximately 40% of that of the untreated control cells, whereas no distinct decrease of 3H‐thymidine incorporation was induced by actinomycin D. Electron microscopic radioautography combined with the AO ultracytochemistry revealed that silver grains indicating binding of 3H‐actinomycin D are located mostly over the euchromatin portion near the segregated nucleolus and heterochromatin and that no or only a few AO chromatin complex was found in nuclei labeled heavily with3H‐actinomycin D. The results of the present study together with the results of the previous studies seem to indicate that AO might selectively bind to active or derepressed DNA template sites for DNA dependent RNA polymerase in the euchromatin portion of the cell

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01028.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

The histological distribution and ultrastructural findings were investigated in 52 amyloid‐positive cases obtained from 80 F, mice (32 males and 48 females) receiving 126 to 502 daily intraperitoneal injections of ferric nitrilotriacetic acid (Fe‐NTA) resulting from reciprocal crossing of 20 parental mice receiving daily intraperitoneal injections of Fe‐NTA for 5 months. Of 52 amyloidotic F1mice 49 (94%) developed a moderate degree of amyloid deposits in the gastrointestinal tract. Moderate amounts of amyloid deposits were sporadically discernible in the lamina propria of the stomach pars glandularis, the duodenal mucosa, and to a lesser extent in that of the rectal mucosa. Electron microscopic observation revealed that macrophages adjacent to amyloid mass were radiating outward abundant bundles of non‐branching amyloid fibrils from the cytoplasmic invaginations. In the cytoplasm of the macrophages there were occasionally acid phosphatase‐positive lysosomes including amyloid fibrils measuring approximately 100 Å in width. Moreover, it is discussed whether fibroblasts or fibroblast‐like interstitial cells are involved in amylo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01029.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

When porcine serum is used to induce hepatic fibrosis in rats, linear septal fibrosis develops and outlines the periphery of Rappaport's functional liver acinus. A sequential morphological study was done to clarify the histogenesis of this hepatic fibrosis, especially in the early stages. Under light microscopic examination, the fibrotic septa developed as a thin fibrotic strand connecting terminal hepatic veins without any massive necrosis. Electron microscopic examination, however, revealed a thickening of the walls of the portal veins with narrowing lumen and damage to hepatocytes prior to the development of fibrosis. There was only mild inflammation and examination showed three types of mesenchymal cells; Ito cells, myofibroblasts, and fibroblasts. These changes suggested that this fibrosis is a result of hepatic damage, which in turn was possibly caused by disturbance of the portal vein.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01030.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Administration of the pineal hormone melatonin to young female rats provided significant prevention of the injurious effects (decrease of body weight gain, atrophy of the thymus and adrenals, glucosuria, elevation of the blood level of glucose, free fatty acid, triglyceride, and total cholesterol) caused by three different glucocorticoids, i.e. dexamethasone, prednisolone, and hydrocortisone. Although these protective effects of melatonin were slightly more remarkable in dexamethasone‐treated rats than in prednisolone‐ or hydrocortisone‐treated rats, our hypothesis of melatonin's anti‐glucocorticoid effects is said to have been confirmed rather universally and with a considerably wide range through this exp

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb01031.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY