摘要:

The incidence of splenomegaly was 39.6% in the nontreated group 41.0% in the treated group, not significantly different between both gr Thymic lymphoma group shared 27.6%, while the nonthymic lymphoma gr 67.9%, significantly different between both. Histological findings of sp megaly of the nonlymphoma groups were divided into the following types. 1) follicular form, 2) periarterial lymphatic sheath form, 3) red hematopoietic form, 4) marginal zone form, and 5) red pulp reticulosis Histology of the spleen in the lymphoma group resembled each form of of splenomegaly in the nonlymphoma group. Lymphoma based upon mune abnormality and specific to this kind of mouse in nonthymic lympl continuously takes place from prelymphomatous changes in the nonlympl group. Splenic origin and role of marginal zone of nonthymic lymphor murine lymphoma is discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01314.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A histopathological study on how the common bile duct and main pancreatic duct open into the duodenum was performed on autopsied cases of infantile obstructive jaundice diseases, and control cases. The so‐called “common channel” formation type (Type III) was divided into two types; the junction of the common bile duct and the pancreatic duct was situated in the mucosal or submucosal layer of the duodenum in type IIIa and the junction below the propria muscularis of the duodenum in type IIIb. Type IIIb was identified in 17 out of 28 cases in congenital biliary atresia and in 2 cases of congenital choledochal cyst, while the control cases all belonged to type IIIa. In cases of type IIIb the well‐developed sphincter muscle was located in the submucosal layer and it surrounded the common channel after joining of both ducts suggesting the possibility of free communication of both ducts. As the intraductal pressure of pancreatic duct is normally higher than that of the bile duct, reflux of pancreatic juice may occur into the bile duct. Abnormal choledocho‐pancreaticoductal junction was suggested to be a pathogenic factor which causes infantile obstructive jaundice

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01315.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Seventy‐nine cases of non‐Hodgkin malignant lymphoma were light and electron microscopically evaluated with special reference to intercellular correlationship comparing with non‐neoplastic lymph nodal cells and cultured B cells. Reticulum cells and histiocytes are regarded as an independent cell unit. Reticulum cell sarcoma shows a fibrosarcomatous proliferation with abundant reticulin fibers, while histiocytic sarcoma is confined to a pleomorphic neoplasm with valid phagocytization. Lymphoid cells are divided into large, intermediate and small lymphocytes. Under inflammation and cultivation they, especially intermediate and large, preferentially proliferated clustering in a reticular fashion, which are designated as reticular lymphocytes, in contrast with nonreticular lymphocytes individually separated. The desmosome‐like junctions are found among reticular lymphocytes not only in but also outside germinal centers as well as in vessels and among cultured B cells. Lymphocytic sarcomas, either nodular or diffuse, are classified into reticular and nonreticular types in association with their cellular sizes. The desmosome‐like junctions are predisposedly disclosed in reticular lymphoma irrespective of proliferating patterns, nodular or diffuse, and of membrane character, B or T. And the junctions are not regarded as a hallmark for follicular or nodular lymphomas of germinal center ce

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01316.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

In an attempt to clarify the etiology of idiopathic pancreatitis, 14 cases of chronic idiopathic pancreatitis were histologically examined. A nest of small cysts consisting of cystic, distended pancreatic ductules with a complete lack of elastic fibers in the wall was observed in 3 out of 14 cases. Studies were then focused on the behavior of elastic fibers in pancreatic ductal system in 100 cases of normal pancreas, 55 cases of chronic pancreatitis and 10 cases of pancreatolithiasis. Partial hypoplasia and/or aplasia of elastic fibers in the walls of pancreatic ductules were demonstrated with a frequency of 30% in normal pancreas, 36.3% in pancreatitis and 50% in pancreatolithiasis cases. Formation of a nest of small cysts was detected in 4 cases of normal pancreas, 3 cases of pancreatitis and 1 case of pancreatolithiasis. It was presumed that these abnormalities of elastic fibers and formation of small cysts containing inspissated secretions might act as potential etiologic or aggravating factors in pancreatitis by a mechanism of either disturbing normal pancreatic outlow or changing pressure in the duct.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01317.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The author has investigated grossly and microscopically 90 intracranial aneurysms among 63 Individuals, autopsied at the Tokyo‐to Medical Examiner Office and partly at the 2nd Department of Pathology, Showa University School of Medicine. These aneurysms consisted of 74 of the saccular type, 5 of the arteriosclerotic type, 6 of the spindle‐shaped aneurysm of the vertebrals and 5 of the dolichoectatic type, respectively. In this paper, the author has discussed the differences of pathogenesis of the above mentioned four types of aneurysms. The saccular aneurysm is thought to occur from turbulence of blood stream by intimal thickening developing from “Verzweigungspolster” (VP) of Rotter15at the neck of the aneurysm, and the arteriosclerotic aneurysm to occur by the same manner as the saccular one, superimposed on severe atherosclerosis during a long time. The spindle‐shaped aneurysm of the vertebral arteries is thought to be of inflammatory nature, relating to slowness of blood stream in the vertebral arteries, and the dolichoectatic aneurysm to be due to hemodynamic disturbance of the vertebro‐basilar artery system by means of atherosclerosis of the arterial walls neighboring to the top of the bas

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01318.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

In order to examine the effect of cemented tungsten carbide dust on the animal lung, saline suspensions were intratracheally administered into the lungs of rats in a single dosage. About one‐fifth of the animals died during the first three days. The acute response of the lungs was hemorrhagic edema with intense alveolar congestion. The animals killed at six months all presented pulmonary lesions of patchy fibrosis in the vicinity of the deposited dusts, occasionally associated with focal traction emphysema and broncho‐bronchiolar ectasia. At twelve months, two‐third of the animals had neither fibrosis nor dust deposition, although the remaining animals showed pulmonary lesions similar to those seen in the six‐months responders. Pibrosis of the lungs seemed to consist of collapsed alveoli with condensation of the preexistent reticulin fibers, but without noticeable collagenization. It is supposed that both the early toxic and the late flbrogenic effects of the carbide dust are attributable to the cytotoxic action of cobalt present in the dust particles. It is possible that recovery of the pulmonary lesions results from removal of the dusts from the

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01319.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Ossification of the posterior longitudinal ligament (OPLL), which causes marked spinal cord compression, occurs more frequently in Japan than in other parts of the world. To investigate the mechanism of this ossification, we examined two cases of mixed type of OPLL inducing severe neurological signs due to spinal cord compression and three cases of segmental OPLL type without neurological signs. Ossification of the ligament begins at the upper end of posterior margin of the vertebral body and distends mainly downward along the posterior longitudinal ligament (PLL) and finally replaces the PLL completely. Ossification consists of compact bones with lamellar structures. In the upper end of the posterior margin of the vertebral body, where the PLL fuses with the cortical bone of vertebral body, ossification always has a direct contact with cortical bone and in this portion proliferation of cartilaginous tissue and calcification were observed. Proliferation of cartilaginous tissue plays a key role in the formation of OPLL and occurs mainly by an enchondral ossification. In three among twenty one cases of cervical vertebrae examined as the control, small foci of ossification were observed which might be related to the initial phase of OPLL. Spinal cords of case 1 and 2 showed marked indentation and flattening with the loss of nerve cells, severe fibrous gliosis of the gray matter and demyelination of the anterior column. Venous congestion due to compression and vulnerability of gray matter to anoxia is important for the histological changes of spinal cord.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01320.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A biopsy case of basal cell adenoma of the submandibular gland was reported in a 15‐year‐old boy. The tumor was pigeon's egg‐sized, spherical in shape and encapsulated by fibrous tissue, and its cut‐surface was grayish white. Histologie feature of this neoplasm was a trabecular or tubular monomorphic adenoma with well‐developed elastic fibers (elastin‐basement membrane complex) in the interstitial tissue. Electron microscopy disclosed 4 kinds of tumor cells, that is, secreting cells, squamous cell‐like cells with tonofibrils and tonofilaments, clear cells with a few filaments, and myoepithelial cells. The interstitium contained elastin, collagen fibrils and basement membrane‐like substance. Possible production of elastic fibers by the myoepithelial cells of this adenom

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01321.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

An autopsy case of tyrosinosis was reported. The patient was a 5‐month‐old boy who had jaundice and hepatosplenomegaly since 10 weeks after his birth. Tyrosine blood level was 6.937 mg/dl and the level of p‐HPPA oxidase low. Neuropathologically, the cerebral lesions were characterized by a spongy state, vacuoles in neuronal cells and focal deposition of PAS‐positive substance in and around the axon. The electron microscopic examination revealed axonal degeneration and unusual deep cortical structure, possibly axons, containing numerous lysosomes, elongated mitochondria and MCB‐like bodies in unmyelinated axon. These facts were suggested to represent morphologic evidence of altered cellular metabolism, related to impaired tyrosine de

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01322.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A case of a 41 years old Japanese woman with widely disseminated primary lung cancer (adenocarcinoma) metastasizing to renal cell carcinoma (hypernephroma) is presented together with a brief review of the literature.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb01323.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY