摘要:

Autopsy series of 19 patients with pineal and anterior third ventricle (suprasellar) tumors were analyzed with regard to shift in pituitary‐adrenal axis. Germinomas formed the most common subgroup in this series (79%). Metastatic tumor growth in the pituitary gland caused adrenal atrophy In 4 cases. Some patients with pineal neoplasms had larger adrenals in weight compared with age‐ and sex‐matched controls of Japanese. In three patients with sexual precocity, adrenal weight was larger. It is concluded that clinical importance exists in anterior pituitary insufficiency with adrenal atrophy, but hyperfunction of the hypophyseoadrenal system might occur during the course of the di

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02075.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Fifty‐two cases of liposarcoma were analyzed clinicopathologically, and were grouped into the following five types: myxoid (28 cases), well‐differentiated (14 cases), pleomorphic (4 cases), round‐cell (3 cases), and mixed (3 cases). Three of the 28 myxoid tumors showed a pleomorphic pattern resembling that of the myxoid variant of malignant fibrous histiocytoma, and one of the 3 round‐cell tumors was considered to be a malignant counterpart of hibernoma. Ages ranged from 22 to 86 years with the average age of 49 years, the average patients with myxoid or round‐cell liposarcoma being over 10 years younger than those with well‐differentiated or pleomorphic liposarcoma. There was also a variation in the site of predilection of the cases: the great majority of myxoid type tumors occurred in the thigh, popliteal fossa and buttock (23 cases), while the majority of well‐differentiated type tumors were seen in the retroperitoneum (10 cases). The rate of local recurrence of the tumor was 46%. Four of the 5 well‐differentiated liposarcomas which recurred exhibited dedifferentiated pleomorphic components resembling those in malignant fibrous histiocytoma. The prognosis was more favorable in patients with ordinary myxoid tumors than in those with well‐differentiated tumors. The overall relative five‐year su

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02076.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Distribution of intracytoplasmic lysozyme in proliferative and neoplastic fibrohistiocytic lesions and non fibrohistiocytic tumors was studied by immunoperoxidase technique on formalin fixed, paraffin‐embedded sections. The cases examined were 161 fibrohistiocytic lesions and 86 non‐fibrohistiocytic tumors. Contrary to our expectation, the lysozyme positive cells were found only in the minority of cases with fibrohistiocytic lesions. Cells positive for lysozyme were found only in 13 out of 100 cases of dermatofibroma, one out of 4 cases of xanthogranuloma and 8 out of 33 cases of malignant fibrous histiocytoma. Dermatoflbrosarcoma protuberans and non‐fibrohistiocytlc tumors were negative for lysozyme. It is suggested that In proliferative fibrohistiocytic lesions, Induction of lysozyme synthesis is weak or absent. Some malignant fibrous histiocytomassh owed scattered lysozyme positive neoplastic cells, indicating their probable histiocytic origin or differentiation. On the other hand, evidence of histiocytic differentiaton of dermatofibrosarcoma protuberans was not obtained using lysozyme immunohistiochem

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02077.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The ultrastructural changes of human or rabbit platelets in response to release inducers I were studied by using isolated cells from the respective platelet rich plasma. The changes of platelets were more dynamic in ADP than those in epinephrine and endotoxin though common changes occurred in all cases. In the platelets on release reaction, there were well preserved alpha‐granules and the disappearance of very dense granules accompanied by simultaneous appearance of round vesicles. The contraction wave of the microtubules rarely occurred and the microfibrils increased in amount in the cytoplasm of platelets. The canalicular system in response to ADP alone is morphologically interpreted as the open canalicular system. On the other hand, epinephrine and endotoxin did not cause obvious morphological changes of the open canalicular system. When the contents of very dense granules alone were discharged leaving the round vesicles behind in the release I, it seems likely that the microfibrils play a more important role than the microtubules. Furthermore, the author suggests that the dense tubular system or third canalicular system may play an essential role for the release I as a secretory pathway in place of the open canalicular syste

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02078.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The ultrastructural changes of the platelets stimulated by release inducers II such as thrombin, collagen, and latex particles were studied to compare the differences in morphology of release I and II. The characteristics of platelets in response to thrombin were the decrease in number of alpha‐granules and marked dilation of the open canalicular system containing fibrin preceded by the disappearance of very dense granules. In the platelets in response to collagen or latex, the release of alpha‐granules was initiated after taking the particles into the open canalicular system. In all of the cases, the amount of microfibrils was seen in the cytoplasm, while contraction wave of the microtubules was rare in the cytoplasm during the release and uptake of particles. Accordingly, the release of very dense granules seems to be followed by that of alpha‐granules. It is suggested that the microfibrils play a more important role than the microtubules in the release II as well as release I. Furthermore, the contents of alpha‐granules may be discharged via the open canalicular system on the release II by thrombin, collagen or latex pa

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02079.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Twenty three mucinous tumors were studied by histochemical, auto‐fluorescence and immunoperoxidase methods, and electron microscopy to investigate the existence of gastro‐entero‐pancreatic (GEP) endocrine cells in mucinous tumors of the ovary. Out of 11 mucinous adenomas, 6 cases contained autofluorescence positive (EC‐) cells and 1 case contained somatostatin‐and gastrin‐cells. Out of 4 borderline malignancies, 4 cases contained EC‐cells and 3 cases contained somatostatin‐ and gastrin‐cells, and of 8 mucinous adenocarcinomas, 3 cases contained somatostatin‐cells and 2 cases contained EC‐ and gastrin‐cells. Electron microscopic observations of 7 cases including 4 mucinous adenomas, 2 borderline malignancies, and 1 adenocarcinoma revealed 3 different types of endocrine‐type granulated cells including EC‐, D‐and G‐cells. Furthermore, muco‐endocrine cell was found in a mucinous adenoma case. These findings agree with the results from autofluorescence and immunoperoxidase studies. The histogenetic origin of mucinous tumors is rather problematic and the appearance of various types of GEP endocrine cells support their endodermal derivation. These results strongly support the possibility that GEP endocrine cells in mucinous tumors are developedin lo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02080.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Argyrophil cells were seen in 2 of 134 cervical tissue blocks obtained from 18 uteri, but none in the endometrium. In 10 of 30 cases of differentiated endometrial adenocarcinoma cells contained argyrophil granules stained with Grimelius method. These argyrophil reactive glandular cells gave positive d‐PAS and Alcian blue (pH 2.5, PH 1.0) reactions, but gave no argyrophil reaction with PAS‐Grimelius double staining method. It was also demonstrated that these glandular cells contained sulphomucins, because High iron diamine (HID) method gave positive reaction with HID‐Alcian blue pH 2.5 double staining. Dense granules, which were submicroscopically seen in cells of well differentiated endometrial adenocarcinomas, were diagnosed as exocrine secretory granules, because of their localization in the cytoplasm and distinct morphological transformation from condensed vacuoles into mature secretory granules. From these findings, argyrophil granules which were seen in cells of the differentiated endometrial adenocarcinomas were thought not to correspond to endocrine granules but mucosubst

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02081.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The cardiac conduction systems including sinoatrial (SA) node, atrioventricular (AV) node, atrioventricular(His) bundle, and peripheral conduction system (left and right bundle branch, and Purkinje fiber) of 23 patients with Duchenne progressive musculr dystrophy(DMD) were studied with light microscope. Infiltration of fat tissue and mild fibrosis were occasional findings in SA and AV nodes. Degeneration of the conduction muscle fiber was hardly noted in SA node, AV node, and His bundle. Only the peripheral conduction system (Purkinje fiber) showed significant degenerations such as eosinophilic, necrotic and vacuolar changes with fibrosis. These necrobiotic changes resembled hyaline and vacuolar skeletal and cardiac muscular degenerations in DMD and were assumed to have occurred on the basis of the structural and constitutional characteristics of the peripheral conduction fiber as a striated muscle fiber. The vascular changes and amyloid deposit suggesting precocious aging in the conduction systems were not observed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02082.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Myosin ATPase activity was fine‐structurally examined in various skeletal muscle lesions including atrophy, degenerations, necrosis, “deltashaped subsarcolemmal lesion”, and apparently normal fibers from seven patients of Duchenne muscular dystrophy (D M D). The enzyme activity was almost completely lost in the foci of necosis, and more or less markedly diminished in various kinds of degenerations, while it was well preserved in the apparently normal and simply atrophic fibers. The results suggested that there were two different lesions in wasting of the skeletal muscles in D M D; necrotic process with degenerations in which myosin‐ATPase activity was affected and simply atrophic process which had little influence on the enzyme activity. The former lesion might be related with direct or indirect damages such as proteolysis, while the latter seemed to be an expression of basically different process such as disuse or denervation, or a more mild expression basically of the same process ultimately resulting in n

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02083.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Effects of heparin, urokinase, and ancrod were concurrently compared on intraglomerular coagulation using a model of progressive Masugi nephritis. Evaluations were performed with light and immunofluorescent microscopy. Treatment significantly reduced crescent formation, more markedly with ancrod. In contrast, endocapillary proliferation was enhanced in the groups treated with urokinase and, especially, ancrod. Ancrod appeared to be most effective in decreasing the glomerular deposition of fibrinogen‐related materials as judged from the immunofluorescence, and a relatively high dose was required for urokinase to be comparable with ancrod. However, in some glomeruli fromtwoof 13 animals given ancrod, mesangiolytic lesion developed. Thus, although promising, ancrod has many problems to be solved before using it to control endocapillary proliferation and mesangiolysi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb02084.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY