摘要:

Acidophilic crystalline inclusion bodies (AGBs) within the cytoplasm of large neurons of the caudate nucleus and putamen were described. ACB was eosinophilic needle‐shaped intracytoplasmic material and electronmicros‐copically composed of filamentous material. Some were found in the cisterns of rough‐surfaced endoplasmic reticulum. There was no histochemical and electronmicroscopic similarity between ACB and Mallory's hyaline bodies of hepatocytes. Though ACBs were noted in a high incidence in alcohol drinkers (65.7%), particularly suffering of alcoholic encephalopathy (72.2%), they were also found in patients without drinking habit (53.9%). In the latter cases, the incidence was high in aged people and patients dying of debilitating diseases (75%) or malignant tumors (57.1%). Consequently, ACB is not pathognomonic for chronic alcoholisms. On histochemical and electron microscopic studies, ACB was considered as a proteinic material, originated from rough‐surfaced endoplasmic reticulum, and resulted from some disordered protein synthesis of the

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02133.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The lymph nodes from 10 cases of histiocytic necrotizing lymphadenitis (HNL), 3 cases of necrotizing lymphadenitis with follicular hyperplasia (NLFH), and 11 cases of various types of lymphadenitis (abscess‐forming, tuberculous, Piringer‐type, “viral”, and nonspecific lymphadenitides) were comparatively studied. The NLFH, clinically representing a milder form of collagen disease, showed necrotizing lesions similar to those of HNL but with follicular hyperplasia, more plasma cells, and scattered neutrophils; the latter features closely resemble those of some lymph nodes in systemic lupus erythematosus (SLE). Ultrastructurally, HNL and NLFH both showed coagul‐ative necroses of individual lymphocytes, the macrophages with large cellular debris, prominent immunoblasts, and cytoplasmic inclusions such as frequent tubuloreticular structures (TRS) and “intracytoplasmic rodlets” (ICR). The necrotic modality in abscess‐forming and tuberculous lymphadenitides was different and the macrophages contained smaller debris. The immunoblasts were less prominent in “viral” lymphadenitis and much less in the others. While TRS were present in may cases of other lymphadenitides as well, they were positive in a much smaller number of cells only; the ICR were found exclusively in HNL and NLFH. These findings suggest a relationship between HNL and NLFH; they may form a spectrum of hyperimmune reaction that includes fSLE as an ex

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02134.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Eight fatalities due to cardiac rupture, of 40 consecutively autopsied myocardial infarctions, were clinicopathologically examined. Total duration of infarctions in 8 cases ranged from 9 hours to 14 days. The longer the period, the more the infarction extended, and aneurysmal dilatation of infarcted wall and tissue weakness were striking. The weakness was caused by the lack of replacement of necrotic muscle fibers by granulation, and was related to aneurysmal structure per se and also to its paradoxical pulsations. Postinfarction cardiac rupture occurring in relatively later phase was considered to be mainly due to weakness of infarcted wall, with less influence factors of mechanical stress such as physical exertion, hypertension, or intracardiac pressure. In the case where cardiac rupture took place in a relatively early stage of the episodes, infarction covered only a small range and aneurysmal change of the ventricle was slight, for which dynamic factors, represented by the degree of a localized strain elicited by myocardial contraction of non‐infarcted site, seemed to play a significant rol

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02135.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The adenylate cyclase and 5′‐nucleotidase activity was measured biochemically in the thyroid glands from patients with various thyroid diseases in comparison with normal thyroid. The basal adenylate cyclase activity in normal thyroid was 159.3 p‐moles cAMP/min./g tissue. The activity was elevated to 230% of basal with 20 mM NaF and 190% of basal with 100 mU/ml TSH. These values in chronic thyroiditis and Graves’disease were not significantly different from the values of normal thyroid. In adenomatous goiter, adenoma and carcinoma, the basal adenylate cyclase activity was significantly higher than that of normal thyroid. Parallel to the biochemical determination of both enzyme activities, the distribution of histochemically demonstrable adenylate cyclase and 5′‐nucleotidase activity was described in the follicular cells with normal and various thyroid diseases. The reaction product of adenylate cyclase and 5′‐nucleotidase activity was restricted to the plasma membrane of the follicular cells. However, the distribution and intensity of the adenylate cyclase reaction varied in each thyroid disease, except for the absence of reaction product in the basal plasma membrane. The lack of demonstrable adenylate cyclase activity in the basal plasma membrane suggests the possibility that the basal plasma membrane may not play an important role o

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02136.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

This paper referred to primary Immunodeficiency diseases (PID)‐malignancy association in autopsy cases in Japan. The occurrence of malignant neoplasms almost centered upon ataxia‐telangiectasia among PID in Japan. It seems to be due to extremely shorter life span in Japanese patients with PID except for in those with ataxia‐telangiectasia, compared with that in European and American patients. Most of the malignant neoplasms seen in Japanese patients with PID were epithelial and were seen mostly in older patients, while lymphoreticular tumors were rare. Gastric cancer was the most frequent of the epithelial t

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02137.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Fatty liver was induced in the rats shortly after administration of cycloheximide, ethionine, orotic acid, monensin or colchicine. It was strongly suggested that derangements in one or more of the hepatic lipoprotein metabolic steps, which occur at the levels of endoplasmic reticulum, Golgi apparatus and secretory vacuoles lead to an accumulation of triglyceride within hepatocytes.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02138.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Using fractionation, subcellular pathogenesis of the fatty liver was investigated. Floating lipids were isolated from a small amount of the liver obtained by needle biopsy. The volume of the floating lipids was correlated to the grading of fat infiltration of the intact tissue. Of lipid‐rich particles bound by membranous structures, the volume of lipolysosomes in the patients with liver damage associated with diabetes mellitus was greater than that of alcoholics. Hypercholesterolemia was another feature characteristic of the liver disease exhibiting lipolysosome proliferation. These observations suggest a lysosomal involvement in fatty degeneration of the liver in diabetics through an overload of cholestero

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02139.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The effect of a generalized phospholipidosis inducing drug, diethylamino‐ethoxyhexestrol (DH, a coronary vasodilator), was studied using rats. The initial alterations are characterized by the appearance of abnormal cytoplasmic inclusion bodies. At the early stage of DH administraion, they appeared near the Golgi apparatus. Histochemical and ultrastructural evidence showed that the inclusion bodies consisted of polar lipid, mainly of phospholipids. From cytochemical and biochemical observation, the lysosome was regarded as the primary site of the drug‐induced morphological changes. The drug‐induced abnormal cytoplasmic inclusion bodies were of three basic morphological types, i.e., multilamellated, crystalloid and finger‐print‐like bodies. Additionally, many intermediate forms were found showing structural features of those basic types. These drug‐induced cytoplasmic changes, namely storage of phospholipids, were considered to be reversible both morphologically and biochemically after the cessation of DH adm

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02140.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A large number of foamy cells were noted in the spleens from fourteen ITP patients, and two patients ‐who received a large amount of platelet rich plasma. Using the unlabelled immunoperoxidase method, these foamy cells were shown to contain platelet antigen. Platelets in varying stages of intracellular digestion, from intact‐apperaring forms to myelin‐like materials, were disclosed in foamy cells.Foamy cells were experimentally induced in granulomas by subcutaneous injection of platelets with or without accompanied administration of steroid, the platelets reacted with anti‐murine platelet antibody, commercialized phospholipids (PE, PC, SM, PS, and the mixture of them), and the red blood cell membrane. The foamy cells induced by the subcutaneous injection of platelets are similar to those in the spleens of ITP patients. The lipid in foamy cells is chiefly derived from the membrane phospholipid of injected platelets. Concentric myelin‐like materials were also noted in the foamy cells after injection of erythrocyte membrane. The myelin‐like materials in these foamy cells are similar to those appearing in macrophages following injection of PC and SM. This suggests that these phospholipids derived from cell membrane are more resistant to intracellular digestion by lysosomal enzymes. We conclude that the foamy appearance of the cordal macrophage in ITP spleens results from incomplete intracellular degradation of platel

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02141.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The fundamental infrastructure of lipid storage in the xanthoma cells of various xanthomatous diseases, including familial hyperlipoproteinemia type Ha, III, and V, cerebrotendinous xanthomatosis, Wolman's disease, Tangier disease, Hand‐Schiiller‐Christian disease, and normolipidemic cutaneous xanthomatosis, revealed lipid vacuoles, either membrane‐bound or with no single unit membrane, cholesterol crystals, multivesicular or multi‐locular lipid bodies, myelin‐like bodies, and ceroid granules (residual bodies). According to the presence or absence of such a single unit membrane and enzyme cytochemical demonstration of acid phosphatase activity, these lipid storage inclusions were largely classified into lysosomal and non‐lysosomal ones; the former included membrane‐bound lipid vacuoles, cholesterol crystals, multivesicular or multilocular lipid bodies, myelin‐like bodies, and ceroid granules and the latter was lipid vacuoles with no limiting membrane. The ultrastructural relationship on formation of these lysosomal and non‐lysosomal lipid storage inclusions and pathogenesis of the lipid storage in the xanthoma cells of the disorders were presented. As for the origin of the xanthoma cells, the majority of them were considered to be derived from macrophages in many of the diseases; however, transformation of fibroblasts into xanthoma cells was confirmed in xanthomatous diseases, such as Hand‐Schiille

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1983.tb02142.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY