摘要:

The response of rat pituitary somatotrophs to transplantation of the MtT‐W10 pituitary tumor and prolonged treatment with large doses of purified bovine growth hormone was examined. The effects of hypo‐thalamic lesions on the somatotrophs were also studied.Involution occurred in somatotrophs of the anterior pituitary of rats bearing a transplantable tumor. The changes in the somatotrophs were observable at 4 weeks and consisted of smaller cells and fewer secretory granules.Administration of growth hormone produced a triphasic response; (1) increased cross‐sectional area of cell, increased size and number of secretory granule, (2) return of parameters to normal levels, and (3) suppression of somatotrophs by exogenous growth hormone.Following destruction of ventromedial nucleus (VMN), the number of secretory granules per somatotroph increased. Concomitantly, there was an enlargement of the mean diameter as well as an increase in the mean surface area of the somatotrophs. After destruction of dorsomedid nucleus (DMN), the number of secretory granules decreased rapidly and reached the lowest level. Two days after the operation, the secretory granules re‐accumulated very slowly in the cytoplasm but remained below control level. Accompanying the decreased granule count, the mean diameter of the largest granule was smaller than that of the controls during all experimental

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01237.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Two thousand four hundred and fifty‐four autopsy cases of various mycoses were reported during the twelve‐year period from 1958 to 1969. These account for 1.203 % of all cases reported in the Annual of the Pathological Autopsy Cascs in Japan during the said period.The results of a statistical survey of deep mycoses in Japan as viewed from findings in a long series of autopsy cases are briefly described. It is noteworthy that (1) there is a nation‐wide distribution of mycoses throughout the country, where the most frequently affected organ was noted to be the esophagus for Candida and the lungs for Aspergillus and Cryptococcus, respectively; (2) common mycoses show a trend toward progressive increase in incidence whereas mucormycosis displays a tendency to decrease; and (3) frequently coexistent conditions which underlie secondary deep mycoses, especially leukemia, malignant lymphoma and aplastic anemia, were observed to show a conspicuous trend to diminish in incidence when viewed from ratios to total numbers of autopsy cases of respective dis

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01238.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Focal glomerular lesions were light microscopically found in 32 out of 436 renal biopsies by blind selection. Glomerular lesions in focal distribution are not an independent disease entity and may include a variety of diseases. They may be found in the early stage of some diseases which will progress to a diffuse lesion and also represent defective healing leaving persistent proteinuria or hematuria.The judgement of the presence of focal glomerular lesions should be based on the prominent changes such as nodular segmental mesangial proliferation, adhesions, segmental hyalinosis, organized crescent and localized necrosis. In a very strict sense there were almost no normal glomeruli at the level of electron microscopy. The result of quantitation of mesangial area and nuclear counts suggests that normal appearing glomeruli are not absolutely normal. Serial section study may disclose hidden segmental lesions.The clinical outcome of patients with focal segmental lesions is not simply favorable. Proteinuria or hematuria often perisisrs as long as 10 years or more; however, only a few cases fall into chronic renal failure.Historical background of this condition was also reviewed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01239.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

To clarify the pathogenetic factor of human chronic glomerulone‐phritis (CGN), acidic citric buffer eluates of the renal basement membranes (RBMs) purified from the kidneys obtained at autopsies and corresponding sera of 7 CGN, one Alport's syndrome and 22 other renal or non‐renal disease cases were immunopathologically examined.The renal eluates from all CGN cases contained certain amount of immunoglobulins especially IgG, the quantities of which roughly paralleled with the morphological activities of glomerular changes. Most renal eluates from CGN cases showed not only in vitro anti‐RBM antibody activity by Boyden's method of passive hemagglutination against the trypsin or collagenase digested and solubilized human RBM, but also in vivo glomerulonephritis producing capacity to rat kidneys with mobilization of complement fraction to the glomerular basement membrane (GBM) after intravenous administration to the animal. These findings lead to the postulation that considerable number of human CGN cases might be caused by anti‐RBM active autoantibody, which might have been in some way produced in the bodies and fixed to the RBM especially to the GBM, conducting initiation and progression of CGN course.As to the antigenic determinant(s) of RBM against anti‐RBM antibody, it was suspected that protein or polypeptide moiety of RBM constituents plays a more important role than polysaccharide moiety of glycoprotein or gly

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01240.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Comparative histochemical study for γ‐GTP and alkaline phos‐phatase was performed in several disorders of liver.Areas of extensively proliferated fibrosis in chronic active hepatitis and areas of newly formed fibrosis in cirrhosis showed prominent activity of γ‐GTP but poor activity for alkaline phosphatase. On the other hand, alkaline phosphatase activity was remarkably high in the connective tissue around proliferating bile ductules.Activity of both enzymes was prominent in the bile canaliculi and sinusoidal walls in obstructive jaundice, but marked decrease or loss of activity of the enzymes was observed in the degenerated or necrotic areas. While fatty degeneration of hepatocytes showed no increase in activity of the enzymes, prominent activity of γ‐GTP was noted in the connective tissue surrounding degenerated hepatocytes in alcoholic liver disease.There was marked activity of γ‐GTP in most tumor cells of hepatoma, while in metastatic tumor the activity of both enzymes was noted in only bile canaliculi and sinusoidal wall adjacent

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01241.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

A case of meningioma with marked extracranial remote metastases is described.The patient was a 33‐year‐old female and was operated according to a diagnosis of parasagittal meningioma in both frontal lobes. Nine years later, however, she died of local recurrence and extracranial metastases in the lungs, liver, pancreas and vertebrae. Histologically, the tumor was diagnosed as angioblastic meningioma with high cellularity, some mitotic figures and abundant intersecting network of reticulin fibers frequently outlining vascular architectu

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01242.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

An autopsy case of Creutzfeldt‐Jakob disease is reported in a 60‐year‐old man who developed an abrupt onset of delusion, intellectural deterioration and rapidly progressing dementia terminating in decorticated rigidity. Autopsy revealed a moderate gyral atrophy of the cerebrum, particularly in the frontal lobe (1320 g). Microscopically, diffuse and prominent status spongiosue was observed throughout the cerebral cortices, mostly accompanied by atrophy and occasional loss of neuronal cells. Similar changes were seen in the basal ganglia. Lipid pigments accumulated in most of the atrophic neuronal cells. Histochemical studies were made on vacuoles of the spongious state and lipid pigments stored in the neuronal cells. Clinico‐pathological subjects of the Creutzfeldt‐Jakob disease and its subtypes, especially its relationship to subacute spongiform encephalopathy, are briefly

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01243.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

An autopsy case of a 62 year‐old Japanese woman who showed marked hyperglobulinemia and anemia with two kinds of M‐components (IgG(L), Bence‐Jones protein(L)) and pyroglobulin was presented.There was no tumor formation detectable by repeated roentogeno‐graphic examinations in the skeletal system during the clinical course of one year and two months or on the autopsy table.Histologically, however, infiltration of plasma cells showing only mild atypia was noted diffusely in the bone marrow, spleen and lymph nodes. There was also a considerable infiltration of the same in the liver, kidney, ovary and lung. While, throughout the clinical course, leukemic increase of plasma cells in the peripheral blood was not found. No significant underlying chronic disorders were disclosed.Fairly rapid down‐hill course, a myeloma pattern of the serology and the pathological findings of this case denoted primarily a neoplastic proliferative disorder of the plasma cell, and thus this was diagnosed as so‐called diffuse myeloma.A short review was made on the literatures of diffuse myeloma and pyrog

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01244.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

Four cases of neurofibromatosis complicated by intracranial tumors are reported. Case 1 showed an intracranial neurofibromatosis while the other three cases contained gliomas in various stages of malignancy.Japanese autopsy records for 11 years from 1958 to 1968 were investigated from a statistical point of view. Meningiomas and neurinomas associated with neurofibromatosis show an earlier peak of age distribution than that of those tumors without neurofibromatosis. There is no different age distribution between gliomas related to neurofibromatosis and the ones not related to it.These facts suggest that both neurinomas and meningiomas associated with neurofibromatosis are intracranial manifestations of neurofibromatosisperse, while complicated gliomas are thought to be an incidental neoplasm, probably associated with transformation of disoriented neuroglial rests.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1974.tb01245.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY