摘要:

The Valvular structure developing at the site from which an artery was given off was examined. The valvular structure consisted mainly of smooth muscle cells, and was found at the openings of such small arteries as the intercostal and lumbar arteries. It was a crescent membrane‐like structure extending from the peripheral edge of the opening to the downstream edge. This structure was indistinct in newborn infants, became gradually distinct in infants and stood out in teen‐agers. It became rather thick and rounded in human beings more than 20 years of age. With further advance in age, the smooth muscle cells became degenerated and hyalinized with some disappearing eventually. In the valvular structure smooth muscle cells running longitudinally in the same direction as the blood stream were arranged in such a manner as a Venetian blind. This arrangement seemed to suggest that the valvular structure might have some function to adjust the blood stream at the branching portion of the aorta. ACTA PATH. JAP.: 669–676,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00935.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

To investigate the presence of intraglomerular immunoprotein deposition in chronic pyelonephritis (CPN), 29 renal specimens from patients with various urological diseases were examined by immunofluorescence. The relationship between immunohistological Andings and types of glomerular changes which were classified according to Heptinstall's criteria was studied. Only type 2 glomeruli, which were considered to be ischemic changes, demonstrated granular and globular depositions of IgM and C3 in the collapsed and solidifled shrunken tufts. IgM was positive in 117 of 258 (45.3%), and C3 in 122 of 264 (46.2%) type 2 glomeruli. The distribution patterns of IgM and C3 were much the same. IgG and IgA were rarely observed and neither fibrinogen nor albumin was observed in the tufts of type 2 glomeruli. Normal glomeruli and other types of glomerular changes in CPN showed few or no intraglomerular immunoprotein deposition. ACTA PATH. JAP.29: 677–685, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00936.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The tissue differentiation of the zona glomerulosa of the fetal adrenal cortex of rats was studied by giving experimental treatments to the fetus in vivo. A low‐glucocorticoid‐condition was given to the fetus by bilateral adrenalectomy of pregnant rats for removing exogenous glucocorticoids from the fetus, and by brain aspiration of the fetuses for removing the fetal pituitary gland (ACTH) and endogenous glucocorticoids. When the fetus was placed under a low‐glucocorticoid‐condition for the last couple of days of gestation, poor differentiation of the zona glomerulosa occurred speciflcally in the fetal adrenal cortex. The degree of the poor differentiation seemed to be proportional to the duration of the low‐glucocorticoid‐condition. Supplemental administration of glucocorticoids could prevent this poor differentiation of the zona glomerulosa. These results indicate that the tissue differentiation of the zona glomerulosa of the fetal adrenal cortex depends much on gluc

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00937.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

SHR rats (Nihon Rat Inc.) were used to study spontaneous arterial lesions morphologically resembling human periarteritis nodosa (PN). Male SHR rats (159) developed PN in 76.1%, whereas females (39) in 10.3% during a period of 2 to 15 months of age. The frequency of PN in male SHR rats tended to increase with ageing and reached 100% at 9 months of age. PN lesions were widely distributed with only the lungs, brain and aorta being spared. PN in females was restricted to the tongue, parametrium and mesenterium, Male SHR rats with hypertension of more than 180 mm Hg showed PN in 81.7%, whereas in females with the same hypertension PN was found in only 17.4%. Although there was apparent sex difference in the incidence and background of hypertension, male SHR rats might be a useful animal model of human PN.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00938.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Intracytoplasmic localization of immunoglobulins in neoplastic cells of malignant lymphomas was studied by both light and electron microscopic immunoperoxidase methods. This was demonstrated in 17 out of 71 cases submitted to light or electron microscopic immunoperoxidase methods. Out of 19 cases examined by the electron microscopic immunoperoxidase method, immunoglobulins were intracellularly identified in 10 cases; 3 out of 6 cases which were diagnosed as follicular lymphoma, 3 out of 5 cases of reticulosar‐coma, 2 out of 6 cases of lymphosarcoma and 2 cases of immunoblastic sarcoma. Out of the above 10 cases, IgM was demonstrated in 9 cases except one of immunoblastic sarcoma in which IgA, IgG and IgM were identified intracellularly. In addition to these findings, our ultracytological and pathological studies have indicated that immunoglobulin‐producing tumors can be classified into the following three major groups according to their cellular origin; germinal centers(group 1), primary follicles (group 2) and extrafollicular (group 3). Group 1 is comprised of follicular lymphoma and reticulosarcoma, group 2 lymphosarcoma, and group 3 immunoblastic sarc

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00939.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Adult T cell leukemia was classified into two distinct types, monomorphic and pleomorphic, according to their histological and cytological features. The former type is composed of uniform neoplastic cells with round or slightly indented nuclei without any marked deformation. The latter type, on the other hand, occupies a unique position in lymphocytic leukemias with the following characteristics: a) onset in adulthood, b) an acute and subacute course, c) well‐differentiated T cell origin of the neoplastic cells, d) pleomor‐phism of the neoplstic cells with markedly deformed nuclei, e) difkuse proliferation of the neoplastic cells without nodular pattern, f) histologically heterogeneous features of lymph nodes frequently admixing a cluster of normal lymphocytes, proliferation of macrophages and dendritic cells, and well‐developed high endothelium venules, g) high incidence of skin lesions due to the infiltration of neoplastic cells, and h) exclusively limited localization of patients' birth p

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00940.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Fifty‐two cases of non‐Hodgkin's lymphomas were studied with enzyme histochemical methods. Forty‐four cases of these were also investigated for surface markers with immunological techniques, and results of histochemical, routine histological and immunological observations were correlated. Twenty‐one of 27 B‐cell lymphomas showed prominent ATPase activity, while all 13 T‐cell lymphomas, except one case, did not show such activity. Nodular lymphomas, though of B‐cell nature, were often negative for ATPase and it remained negative after diffuse evolution in some. Four of 7 AlPase positive lymphomas were of B‐cell origin. Dot‐like localized AcPase and β‐glucuronidase activity characterized T‐cell lymphomas while 5 T‐cell PDL, including lymphoblastic type with double markers, showed localized esterase activity. Enzyme histochemical characteristics of lymphomas were fairly honest reflection of those of various functional units in the normal lymph nodes. Enzyme histochemical methods appeared to be a useful tool fo

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00941.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A new classification for non‐Hodgkin's malignant lymphoma is proposed as the one suited for the Lymphomas in Japan, which is to provide a new subtype “pleomorphic” for those more or less rapid‐growing lymphomas of peripheral T‐cell nature, along with another subtype lymphoblastic, after Nathwani et al. for those of central T‐cell nature. The proposal is based on the result of the investigation by the Study Group for Histopathological Diagnosis on Malignant Lymphoma that (1) the presence of a significant number of T‐cell lymphomas with peculiar “pleomorphism” is responsible for the very low reproducibility rate of histopathological diagnosis on the diffuse, mixed L&H type of Rappaport classification, and (2) the relative incidence of lymphoms of peripheral T‐cell nature including the so‐called adult T‐cell leukemia is much higher in Japan than i

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00942.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A necropsied case of macroglobulinemia Waldenström with unusual complications was presented; the patient was found to have autoimmune hemolytic anemia, first. During the course of its treatment, he developed monoclonal immunoglobulin M in serum together with lytic osseous lesion in both femurs, and died of meningeal involvement by tumor cells. Clinically, he had hepatosplenomegaly and generalized lymphadenopathy. The macroglobulin was kappa type of light chain, ultracentrifugation showed a sharp spike of 21S in 18.6%, and myelogram revealed increased lymphocytoid series of 29.6%. It was proved that autoantibody causing autoimmue hemolytic anemia was composed of IgG and macroglobulin itself had no activity as an anti‐red cell antibody. An emphasis was made that autoimmune hemolytic anemia followed by macroglobulinemia is based on the state of immunodeficiency of this patie

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00943.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The ultrastructure of benign osteoblastoma of the maxilla in a 14‐year‐old boy was studied. Morphologically, the tumor tissue was composed of abundant osteoid of a trabecular form, and cellular and vascular connective tissue. The cellular components were osteoblasts, osteoclasts, osteocytes entrapped within the osteoid, and small perivascular cells of two types. The small cells of one type were ovoid and had a relatively large nucleus and a dark cytoplasm. The cells of the other type were elliptical and had a clear cytoplasm. The former seemed to be a preosteoblast and the latter could not be identified. The osteoblast was the predominant cell in this lesion and was characterized by the presence of abundant rough‐surfaced endoplasmic reticulum and several Golgi complexes. These characteristics indicated the pronounced activity of collagenous fiber synthesis and the matrix of the osteoid t

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00944.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY