摘要:

For the purpose to study the humoral control of defensive responses, kinetics of colony forming cells (GFC) In peripheral blood of histamine ‐injected mice was assayed by modification of McCulloch and Till's method, with usual hematological examinations. Effects of histamine on adrenalectomized mice and hydrocortisone injection into intact animals were also examined in the same manner. In conventional mice, histamine caused marked leukopenia and a rise of hematocrit value by 15 minutes after the injection, the latter of which was restored within 30 minutes. On the other hand, high hematocrit value continued for more than 1 hour in adrenalectomized mice.Histamine administration into conventional mice caused a temporary increase of peripheral CFC by 1–3 hours after the injection, accompanied by granulocytosis. Afterwards, CFG count reverted to control level. In adrenalectomized mice, count of peripheral CFG was about two times of that of control. Histamine administration into adrenalectomized mice caused remarkable increase of peripheral CFC by 3 hours after the injection. On the contrary, hydrocortisone decreased peripheral CFC count distinctly. ACTA PATH. JAP. 20: 141 ‐ 152,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02742.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The present study consists of 16 cases of idiopathic cardiomyopathy ranging between 7 to 68 years of age. All cases demonstrated moderate degree of dilatatory hypertrophy of both ventricles with some having mural thrombosis. Over‐all distribution of scar and degeneration of heart muscle cells was considered to be the characteristic features of idiopathic cardiomyopathy. A variety of transitional changes between myocardial degeneration and collagenous scars were found in the younger age group, and fall‐off of myocardium was interpreted to result in scar formation. Hypertrophy of heart muscle cells is a compensatory phenomenon following partial fall‐off of muscle cells. Vacuolar changes, deposition of waxlike substance and bizarre nuclei found in the hypertrophic muscle cells are in general not characteristic for this condition.One must be careful in differentiating idiopathic cardiomyopathy and mitral insufficiency having multiple scars and of rheumatic nature from both clinical and pathologic standpoints.Endocardial fibroelastosis should not be included in the entity of idiopathic cardiomyopathy, since the role played by the myocardium in the pathologic process is much less in endocardial fibroelastosis. ACTA PATH. JAP. 20: 153–16

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02743.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

An autopsy case of sarcoidosis associated with intermittent fever and marked splenomegaly and 28 biopsy cases were studied on its histological changes according to the stage. Diffuse lymphoreticular histiocytosis was considered to precede typical granuloma formation, though it has not been mentioned in the literature. Hyalinizing fibrosis following epithelioid cell granuloma occurred fairly rapidly and frequently from the periphery of the tuberculoid granuloma and progressed towards the inside of the granuloma with only giant cells of the foreign body type remaining. The entity of this phenomenon has been referred to as localized immune mechanism or local hyperglobulinosis. The author recognized the evidence in a previous study that immune globulins, polyclonal in type, were concentrated in and around the granuloma. From the concept that some antigenic agent consists in the Kveim reagent, the direct method of fluorescent antibody technique was introduced and distinctive fluorescence suggestive of an antigenic agent was obtained. ACTA PATH. JAP. 20: 171 ‐ 182, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02744.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The right ventricular myocardium of the cor pulmonare in the rat induced by subcutaneous single injection of monocrotallne has been studied by electron microscope. The hypertrophy and wearing of myocardium was sequentially categorized into (1) preparatory stage, (2) hypertrophied stage, and (3) damaged stage.Slightly enlarged and injured mitochondria and incomplete division of mitochondria were noticed in the first stage. An increase in number of mitochondria, appearance of giant mitochondria, many free ribosomes and small bundles of myofilaments were recognized in the second stage. In the third stage, mitochondria located in the subsarcolemmal region and between the myofibrils tended to migrate to the central portion of the muscle cell, and the myofibrils were simultaneously pushed away towards the plasma membrane. A large number of spherical, electron‐opaque granules, not containing acid phosphatase, were found in the enlarged central sarcoplasmic core. The transverse cell boundary was expansively widened at the intermediate junction and its space contained many small membrane‐limited particles. Injured cells, reduced in size, were isolated and localized in the tissue space. After degeneration of this cell, it is finally replaced by collagen fib

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02745.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Two autopsy cases of congenital hydronephrosis are reported, and a short comment was made concerning its pathogenesis.One was unilateral and caused by membranous obstruction at the ureterovesical junction, and the other was bilateral and due to fibrous, cord‐like change of both ureters about 1–2 cm below the ureteropelvic junction. Comparative studies were made between our two cases and with cases which had been published so far in Japan and in some other countries. ACTA PATH. JAP. 20: 207–213,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02746.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

A 49‐year‐old Japanese woman, who developed adrenal and thyroid insufficiency approximately 8 years prior to death and expired from adrenal insufficiency was described. No specific endocrinological and immunological tests were performed. Autopsy revealed idiopathic Addison's disease, Hashimoto's thyroiditis, acute glomerulonephritis and primary hyperplasia of parathyroid gland. Reviewing the literature some comments were made on the incidence, morphology and pathogenesis of idiopathic Addison's disease and Schmidt's syndrome. This is the first case of Schmidt's syndrome as well as of idiopathic Addison's disease in Japan. ACTA PATH. JAP. 20: 215 ‐ 226,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02747.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

A case of congenital lipoid hyperplasia of the adrenal cortex in a male baby with male external pseudohermaphroditism who died 79 days after birth was presented. Prominent clinical signs were recurrent vomiting, brown pigmentation of the skin and retardation of the growth. Histologically, the adrenal cortex was characterized by nodular hyperplasia of so‐called spongiocytes loaded with cholesterol ester.Electron‐microscopic study showed that the spongiocytes were filled with numerous vacuoles of very low electron density. These cells also showed cytoplasmic degeneration as indicated by autophagosomes and myelin figures.Chemical analysis of the adrenal tissue revealed that the total cholesterol was four times higher than that in the control, while the ratio of total to esterized form was not significantly different. ACTA PATH. JAP. 20: 227 ‐ 237,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02748.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

A case of diprosopus, a very rare malformation belonging to dupli‐citas, of a female newborn is reported. This diprosopus monauchenos tetrophthalmus triotus dioris was delivered from a 33 years old multipara. Autopsy revealed duplication of cerebral hemispheres, 1st, 2nd and 3rd cranial nerves, hypophysis, intracranial internal carotid arteries, basilar artery and tip of tongue. This diprosopus had also congenital cardiac and great vessel anomalies consisting of double outlet right ventricle without pulmonary stenosis, coarctation of aorta (infantile type), ventricular septal defect, patent ductus arteriosus, patent foramen ovale and thick right ventricular wall. Except for mesenterium commune, the organs in the chest and abdomen, and the extremities were normal in position, shape and number. ACTA PATH. JAP. 20: 239–249, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02749.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Autopsies were carried out on a ten‐month old male and another 7‐year‐old boy who died within a few days after showing slight upper respiratory infection as a prodromal symptom, followed by vomiting, disturbances of consciousness and high fever. Both of these cases showed high transaminase levels, accompanied by low blood sugar, and patho‐anatomically, they had marked fatty degeneration of the liver and kidneys, and remarkable edema of the brain. The lung showed a slight inflammation of the interstitiums. Only mild inflammation was found in the intestines.These clinical and pathological findings coincide with the conception of Reye's syndrome, and some discussions have been made about the differentiation between Reye's syndrome and those closely resembling this syndrome. ACTA PATH. JAP. 20: 251–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb02750.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY