摘要:

Expression of IgD was studied immunopathologically on 50 cases of B cell lymphomas (B MLs), together with various B cell markers including IgM, ϰ and Λ chains, B1, B2, (OK)B2, (OB)B7, (OK)T10, NUB1, Leu 1, Leu 14, and PCA. IgD was demonstrated on 19 cases heavily and on 8 weakly. It associated well with expression of two antigens, B2 (C3d receptor molecule) and Leu1 (pan‐T antigen), besides IgM, while, B2 was closely related in expression on B MLs to (OK)B2, (OK)B7, and NUB1. Λ chain was dominant on IgD heavily‐stained cases. Histopathologically, IgD positive MLs were distributed in various types. All of diffuse intermediate type were shown to be IgD positive (4/4, 3 heavily). As cases of this type were shown to express most of other B cell antigens present on non‐tumorous primary follicle B cells or mantle zone B cells, this type of MLs is speculated to be a neoplastic counterpart of such non‐tumorous B cells. Eight out of 18 cases of diffuse large cell type were IgD heavily positive, suggesting some unusual mechanisms in IgD expression on these neoplastic large cells, as non‐tumorous B cells lose most of their surface IgD soon after blastoid transformation. Other types of MLs were discussed with special emphasis on expression of IgD. ACTA PATHOL. JPN. 36: 142

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02815.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

The morphological and immunological features of 22 patients with transformation of Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) were evaluated. Patterns of differentiation in blast crisis were as follows: myeloblastic 5 cases, lymphoblastic 6 cases, basophil differentiation 4 cases, monoblastic 3 cases, megakaryoblastic 1 case, and mixed 3 cases (myeloblastic and lymphoblastic, monoblastic and lymphoblastic and panmyelosis). Three cases were diagnosed as acute lymphoblastic leukemia (ALL) in early stage. After complete remission was achieved rapidly with vincristine and prednisolone, the hematological findings showed CML features. The immunological phenotype of lymphoblasts in lymphoid crisis was Ia+, CALLA+, surface and intracytoplasmic immunoglobulin negative. It was suggested that the neoplastic cells in two cases had B cell differentiation because of B1 or B4 positive. The terminal deoxynucleodidyl transferase (TdT) activity was examined by immunoperoxidase and immunofluorescence techniques on 11 cases. All TdT+cells were the small lymphoid cells in 5 cases of lymphoid crisis and one case in mixed type. Heterogeneity of the terminal phase of CML was recognized. It was thus suggested that blast crisis of CML occurred in the pluripotent stem cell. ACTA PATHOL. JPN. 36: 1441‐1454, 19

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02816.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Lymphocyte subsets in the tumor nests of breast carcinoma were immunohistochemically investigated and a quantitative analysis was added. The majority of cases showed predominance of T cell and suppressor T cell (T8). A decrease in number of lymphocyte subsets and the helper T (T4)/T8 ratio in the stroma of tumor nests correlated well with the progression of clinical stage and the presence of metastasis. This correlation could not be found in the peripheral region of the tumor nests. Macrophages and NK cells were infrequently observed only in the peripheral region of ductal carcinoma. T cell infiltration was prominent in medullary carcinoma with lymphocyte infiltration (MC), and macrophages, NK cells, and T zone histiocytes were frequently encountered. For the purpose of knowing the activity of T cells, IL‐2 receptor (Tac) and transferrin receptor were examined irnmunohistochemically. The fact that a few activated T cells were found only in the peripheral region of tumor nest suggested the local immune response in ductal carcinoma not to be so active as to reject the tumor cells. Since numerous activated T cells were recognized in the tumor nests of MC, this type of breast carcinoma was thought to have a higher immune reactivity. There was little evidence indicating NK cells to play a role for natural cytotoxicity in breast carcinoma. ACTA PATHOL. JPN. 36 1455‐1468,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02817.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Forty‐nine patients with minute carcinoma of thyroid gland (clinically silent carcinoma less than 10 mm in diameter) underwent partial thyroidectomy and regional lymph node dissection. Nodal metastasis was found in 33 patients (67%). Histologically, no difference in the incidence of nodal metastasis was found between sclerosing carcinoma and nonsclerosing carcinoma. During the period of follow‐up (from 3 to 18 years), neither recurrence of the carcinoma nor death was observed in 16 patients without nodal metastasis and 24 patients who had less than 4 metastatically involved nodes. In these 24 patients, most of the metastatic deposits were less than 5 mm in diameter and even the largest one did not exceed 16 mm. Recurrence without death was found in 2 of 4 patients who had many metastatically involved nodes, more than 8, or at least one large metastatic deposit measuring larger than 16 rnm in diameter (moderately involved group), whereas recurrence followed by death occurred in 3 of 5 who had many involved nodes and at least one large deposit (extensively involved group). In both moderately and extensively involved groups, recurrence and death occurred in elder patients. The present study suggested that the prognosis of minute carcinoma depends on the degree of nodal involvement and age of the patient. ACTA PATHOL. JPN. 36 1469‐1475,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02818.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Seven cases of cavernous hamangioma of the liver found accidentally at autopsy were studied by electron microscope. The structures of the hemangioma consisted of capillaries and the intervening stromal cells. The endothelial cells contained pinocytotic vesicles, scattered ribosomes, rough endoplasmic reticulum, and Golgi apparatus. A distinct basement membrane was present beneath the endothelial cells, and multilaminated arrangement of the basement membrane was sometimes observed beneath the endothelial cells. The endothelial cells also contained numerous cytoplasmic filaments, but contained sparse specific endothelial granules. The internal elastic lamina was hardly seen at all in the hemangioma. The stromal cells showed typical smooth muscle cells, modified smooth muscle cells, and fibroblast‐like cells. Elastic tissue as well as collagen fibers was present within the intervening stroma. Neither adventitia nor nerve fibers were found in the cavernous hemangioma. It is thought that cavernous hemangioma of the liver may be of a hamartomatous nature. ACTA PATHOL. JPN. 36:1477‐ 1485, 19

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02819.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

An immunohistochemical study was carried out on 28 cases of giant cell tumor of tendon sheath. Although this tumor has been considered to be of histiocytic origin on the basis of light and electron microscopic findings, there remains some debate about the histogenesis of the tumor. To clarify this point, by using the PAP method, each surgical specimen was stained for α1‐ antitrypsin, a1‐antichymotrypsin, lysozyme, ferritin, neuron specific enolase, and S‐100 protein. Tumor cells in fifteen out of 28 cases were positively stained for α1‐antitrypsin, 19 for α1‐antichymotrypsin, 23 for lysozyme, 22 for ferritin, 22 for neuron specific enolase, but no case for S‐100 protein. These results suggest that this tumor is composed of cells with histiocytic character. In addition, from the immunohistochemical point of view, at least two types of giant cells seem to exist in this disease. ACTA PATHOL. JPN. 36:1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02820.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

A transplantable tumor strain desi?nated YNnu and a cultured cell line desi?nated YN were established from the human paratesticular rhabdomyosarcoma of a 15‐year‐old boy.In vitrothe cells showed ultrastructural features of immature mesenchymal cells, and a few cells were labeled by antibodies to myo?lobin and/or desmin. In nude mice, the cells became to contain numerous myofibrils with Z‐bands, and considerable number of cells reacted with anti‐myoglobin and/or anti‐desmin antibodies. We conclude that spindle‐shaped or small round cells are the most immature rhabdomyoblast with multiplicity for cellular differentiation. ACTA PATHOL. JPN. 36: 1495

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02821.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Increased susceptibility toRhizopus oryzaein diabetes was investigated using mice in which diabetic ketoacidosis was experimentally induced. All of the diabetic mice which had developed ketoacidosis died within four days after inoculation ofR. oryzaeand their serum UIBCs (Unbound iron binding capacity) were significantly lower than those of the normal control mice. This study suggested that the decreased serum UIBC produced by diabetic ketoacidosis enhances the growth ofR. oryzae in vivo. ACTA PATHOL. JPN. 36: 1507‐1512, 198

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02822.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Unexpected sudden cardiac death among children with a history of Kawasaki disease has come to be reported in Japan. Death occurred between 2 months and 8 years after complete recovery from Kawasaki disease according to our study material. To study the lesions of Kawasaki disease sequelae we examined 61 cases of Kawasaki disease which came to autopsy. In 17 of these the deaths apparently to be due to sequelae of this disease, were characterized by cardiac insufficiency caused by ancient coronary aneurysm with or?anized thrombotic occlusion and superimposed acute ischemic myocardial de?eneration and/or necrosis. The age of the lesions appears to correlate with the interval period between complete recovery from this disease and death. Six cases succumbed incidentally of other causes: one traffic accident, one hemophilus meningitis, one chronic myeloid leukemia, one neuroblastoma, one menin?eal hemorrha?e due to rupture of basilar arterial aneurysm, and one acute lymphatic leukemia. Even in these cases, definite sequelae of arteritis were detected. A surgically resected coronary aneurysm and a ventricular aneurysm were also examined. It was disclosed by mass physical check‐up of school children that 0.1% had a history of Kawasaki disease, among which 5‐6% showed cardiac and/or coronary abnormality includin? aneurysms. The high incidence of cardiac involvement in Kawasaki disease has been proved in this study and this kind of lesion has the possibility of resulting in unexpected cardiac death of children. ACTA PATHOL. JPN. 36: 1513‐1527,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02823.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Electron microscopically the role of acid phosphatase (acid P) positive lysosomes in the patho?enesis of intramyocardial coronary artery lesions of hypertensive rats with bilaterally constricted renal arteries was studied. At 3 postoperative weeks, acid P positive lysosomes were increased in endothelial cells of the coronary arteries, but at 5 weeks and thereafter, they were decreased in number. In the intima, intimal smooth muscle cells with acid P positive lysosomes appeared at 3 postoperative weeks, but their number remained small as late as 9 postoperative weeks. The internal elastic lamina was fra?mented into amorphous masses from 3 postoperative weeks, at 5 weeks and thereafter the fra?mentation and disruption became severer, and at 9 weeks the lamina disappeared because of marked disruption. At 3 postoperative weeks, acid P positive extracellular lysosomes were observed in the ?aps of the fra?mented internal elastic lamina. At 5 weeks and thereafter, extracellular lysosomes and attenuated processes of medial smooth muscle cells with lysosomes were seen extending through the ?aps of the fra?mented internal elastic lamina. Necrosis of these extendin? cell processes and lysosomes remainin? after the necrosis were observed. The findin?s su??ested that the fra?mentation and lytic chan?e of the internal elastic lamina observed in hypertensive rat intramyocardial coronary arteries might be induced by extracellular lysosomes dischar?ed not only from endothelial cells and intimal smooth muscle cells but also from the extendin? processes of medial smooth muscle cells into the gaps of the internal elastic lamina. ACTA PATHOL. JPN. 36: 1529‐1536, 198

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1986.tb02824.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY