摘要:

This article reviews aspects of the molecular pathology of cholesteryl ester accumulation in atherosclerotic lesions. 1. Transcytosis of lipoproteins through a cultured endothelial monolayer. 2. Effects of platelets and PGI, on intercellular transport of endothelial cells. 3. Transformation of macrophages to foam cells. 4. Cholesteryl ester deposition in the extracellular space of atherosclerotic lesions. The development and use of novel monoclonal antlbodies recognizing atherosclerotic lesions and peroxidized lipoproteins prepared from then are also discussed. Acta Pathol Jpn 42: 625–631, 199

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03042.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A clinicopathologic and DNA flow cytometric study was performed on seven patients (three males, four females) with atypical adenoma of the thyroid gland, using formalin‐fixed paraffin‐embedded tissues. The results were compared with those of 30 follicular adenomas and 13 follicular carcinomas. The patients ranged in age from 32 to 74 years (mean: 55.8 years), and the mean follow‐up period was 11.0 years. All patients except two who died of other diseases were free of thyroid disease after initial surgery. It showed that there was no evidence of clinical cancer in this follow‐up study of patients operated on for atypical adenomas. Four of the atypical adenomas were diploid, two were aneuploid, and one was tetraploid. Twenty‐seven of the 30 follicular adenomas were diploid. Three patients with aneuploid follicular adenoma were free of disease. Of the 13 follicular carcinomas with a mean follow up period of 6.9 years, five were diploid, seven were aneuploid, and one was tetraploid. Two patients with aneuploid follicular carcinoma and one with diploid carcinoma developed lung metastases, and one patient each with diploid and aneuploid follicular carcinoma died of disease. There was no significant correlation between histologic features, ploidy status and prognosis among follicular carcinomas. The results of this study suggest that DNA flow cytometric analysis is not a useful tool for predicting the clinical behavior of follicular neoplasms. Acta Pathol Jpn 42: 632

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03043.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Data on 43 neuroblastic tumors (30 neuroblastomas and 13 ganglioneuroblastomas) obtained from 22 untreated and 21 pretreated children, were analyzed to determine the correlation between N‐myc oncogene amplification and immunohistochemically identified S‐100 protein positivity. Sixteen patients In whom the tumor showed significant amplification of N‐myc (more than ten copies) died, irrespective of S‐100 protein positivity and other conventional factors. Among 27 patients with low amplification of N‐myc (less than ten copies), the estimated progression‐free survival for those whose tumors had numerous S‐100 protein‐positive cells (P group), and few or no positive cells (N group) was 75% and 17%, respectively (p<0.0001). Thus, in addition to N‐myc oncogene amplification as a reliable indicator of outcome, S‐100 protein positivity should be useful for prediction of prognosis in children with neuroblastic tumors showing low amplification of N‐myc. Correlations among these results and other clinical factors are briefly discussed. Acta Pathol

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03044.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Thirty‐one cases of mammary carcinoma were examined immunohistochemically for the expression of transforming growth factor (TGF) β, fibronectin (FN) and fibronectin receptor (FNR) in order to clarify the reason for the reported relationship between TGF β expression and a high incidence of lymph node metastasis. It was revealed that TGF β expression is closely related to the expression of FN, an intercellular matrix protein, and its cellular receptor FNR, one of the integrins. The interaction between FN and FNR in a tumor is considered to form the basis of the invasive nature of carcinoma cells. Thus, it is suggested that TGF β expression in carcinoma cells induces the interaction between FN and FNR, which may lead to carcinomatous invasion resulting in lymph nodal metastasis. Aeta Pathol Jpn 42: 645–65

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03045.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A 58‐year‐old man developed polyneuropathy, or‐ganomegaly, gynecomastia, skin pigmentation, and multiple myeloma (IgG‐Λ type). Although transient clinical improvement was obtained with prednisolone and cyclophosphamide, his general condition deteriorated progressively, and he died 3 years after onset. Lymph nodes showed angiofollicular hyperplasia, and the sural nerve revealed segmental demyellnation. At autopsy, the glomeruli were enlarged and showed mild mesangial cell proliferation with segmental mesangiolysis and proliferation of endothellal cells forming abnormal vessels. The massive volume of ascites contained a high level of inter‐leukin‐6 (IL‐6). IL‐6, a multifunctlonal cytokine, may be the pathogenic factor which induces the various clinical symptoms and pathological features of Crow‐Fukase (POEMS) syndrome. Acta Pathol Jp

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03046.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The authors report a case of Wegner's granulomatosis with the unusual manifestation of diffuse pulmonary hemorrhage. A 58‐year‐old man complained of bloody sputum and fever. Chest X‐ray films showed multiple nodular shadows in both lung fields. He was diagnosed as having Wegener's granulomatosis by transbronchial lung biopsy, which revealed necrotizing granulomatous inflammation with necrotizing vasculitis. Despite treatment with cyclo‐phosphamide and prednisolone, his condition rapidly deteriorated. An extensive diffuse alveolar shadow appeared in both lung fields in chest X‐ray films, anemia became worse, and he died of respiratory failure. Autopsy revealed diffuse alveolar hemorrhage with necrotizing capillaritis in addition to the typical pathological findings in Wegener's granulomatosis. The capillaritis was characterized by neutrophilic infiltration of alveolar septa, and fibrin thrombi in alveolar capillaries. Diffuse pulmonary hemorrhage is uncommon in Wegener's granulomatosis. However, once diffuse pulmonary hemorrhage occurs, the respiratory condition rapidly deteriorates and is life‐threatening. Therefore, accurate diagnosis and appropriate treatment are required. Acta Pathol Jpn 42: 65

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03047.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A 73‐year‐old Japanese man with a history of partial gastrectomy due to gastric cancer 4 years previously was admitted because of intermittent fever. The patient developed abdominal pain, erythema, and myalgia in addition to the fever during the final clinical course, and died of acute heart failure. Autopsy disclosed atrophy of the left lobe of the liver and acute myocardial infarction. Neither metastasis nor recurrence of the cancer was observed. Small and medium‐sized arteries of the visceral organs showed various stages of necrotizing vasculitis with narrowing of the lumina. The vasculitis was most prominent in the left lobe of the liver and in the heart. Narrowing of the portal vein due to portal tract inflammation in addition to vasculitis of the hepatic arteries may have induced ischemia and infarction, which had resulted in atrophy of the left hepatic lobe. Acta Pathol Jpn 42: 662–66

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03048.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A 75‐year old man initially complained of pollakiuria and low abdomlnal pain, and died of massive bleeding from an exacerbated gastric ulcer. The dlagnosis of primary cardiac lymphoma was made postmortem. The tumor involved only the epicardium and myocardium, which met the criteria of primary cardiac lymphoma as defined by the Armed Forces Institute of Pathology. The lymphoma consisted of large cells and expressed the B cell marker, CD20. Although chronic inflammation due to chronic renal failure was observed in the pericardium around the lymphoma, polymerase chain reaction (PCR) was conducted to detect monoclonality at the DNA level in lymphoma cells, which were shown to comprise a monoclonal population. Acta Pathol Jpn 42: 667–671, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03049.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A 78 year old woman complaining of a neck mass underwent right hemithyroidectomy. The 7×6 cm thyroid tumor consisted predominantly of mildly atypical, epithelial membrane antigen‐positive plasma cells and scattered lymphoid follicles. Features of follicular colonization (plasma cell infiltration into germinal centers) were noted. Numerous CD45RO‐positive reactive T cells and a smaller number of CD2O‐positive blast‐like B cells were also distributed among the plasma cell infiltrate. IgG, x‐type mono‐clonality with J‐chain reactivity was identifled in the plasma cells, including those in the lymphoid follicles. The association of pre‐existing lymphocytic thyroiditis was confirmed histologically in the non‐tumorous thyroid tissue. The tumor exhibited deposition of reticulin flber‐rich, amorphous eosinophilic substances, provoking pronounced foreign body reactions. The deposit, polytypically im‐munoreactive for immunoglobulin γ‐,μ‐, ϰ‐ and Λ chains, β2‐microglobulin and HLA‐DR, was scarcely reactive upon amyloid staining, and consisted ultrastructurally of electron‐dense, non‐fibrillar material and entrapped collagen fibers. Multiple myeloma was ruled out by laboratory, histologic and clinical examinations. The possible categorization of this extramedullary plasmacytoma of the thyroid within low‐grade B cell lymphoma of the mucosa associated lymphoid tissue (MALT) is d

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03050.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A rare α‐fetoprotein (AFP) producing carcinoma that originated in the rectum of a 54‐year‐old man is reported. High levels of AFP are found in the serum (5,126 ng/ml) and homogenate of the tumor tissue (2,600 ng/g). Two morphologic patterns were noted in the tumor. One was that of well differentiated tubular adenocarcinoma and the other was more polymorphous, in which the tumor cells grow in a solid‐sheet with occasional glandular and papillary structures. Hyaline bodies and Schiller Duval body‐like structures were also found in the polymorphous area. There was a gradual transition between the well differentiated and the polymorphous area. AFP was positive in the polymorphous area and negative in the well differentiated area on immunohistochemical examination. These morphologic and imrnunohistochemical characteristics may suggest a differentiation toward embryonal carcinoma of the polymorphous component. Moreover, the polymorphous component showed marked vascular invasion and metastasis of liver as well as regional lymph nodes. AFP‐producing carcinoma cells may be more aggressive than ordinary adenocarcinoma. Acta Pathol Jpn 42: 6

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03051.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY