摘要:

The oral administration of N, N'‐2, 7‐fluorenylenebisacetamide (2, 7‐FAA) induces leukemia, especially mature granulocytic leukemia, in rats. We compared the distribution of nodular foci of 2,7‐FAA‐induced mature granulocytic leukemia with that of transplanted leukemia for the purpose of proving hematogenous development of leukemia. The bone marrow of the vertebral bodies was examined in the cases of scattered lesion of 2,7‐FAA‐induced and transplanted leukemia. The leukemic nodular foci were most frequently located around the center of the craniocaudal axis of the vertebral bodies in both leukemias. On the other hand, they were evenly distributed along the dorso‐ventral axis in both leukemias. The similarity of the distribution of nodular foci between 2,7‐FAA‐induced and transplanted leukemia may be an evidence for the hypothesis that the former is spread by hema

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00905.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

As a part of the series of studies7,8,11on lipid metabolism in ischemic myocardium, the present study was attempted to analyze 29 infracted hearts with acute or scar lesions by a routine histopathology and lipid histochemistry. The time after the onset of attack till death ranged from one day to years. Sixteen were of the acute form, less than 2 month‐old, and 13 were of the chronic scarred form. Within the first day, fat deposition appeared in the survived muscle cells around the infarcts reaching the peak from 2 days to one week, but necrotized cells never contained fat droplets. Macrophages in granulation tissue in periphery of the infarcts tended to have significant fat droplets usually in 10 days to one month. Fat disappeared from the survived muscle cells and also from the scar later than 2 months. The survived cells around the infarcts might be degenerated with fat, probably triglyceride, which accumulated by a relative ischemia not severe enough to produce coagulation necrosis, and they bear some relationship with extension or limitation of size of infarct

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00906.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Three different macrophage chemotactic factors were separated from hypersensitivity skin lesions induced by DNP‐ascaris extract or PPD. The amount of each factor seemed to be changeable according to the nature of inflammatory stimuli. The chemotactic activity of the factor a was completely absorbed by anti‐IgG and anti‐light chain antibodies, while that of the factors b and c was not absorbed by the antibodies. The factor a was produced from IgG by neutrophil neutral serine protease resembling elastase but fatling to digest elastin‐orcein; its chemotactic generation was accompanied by release of dialysable peptide(s) from the IgG molecule, suggesting a minor structural change of the IgG molecule. Production of leucoegresin or lymphocyte chemotactic factor by europhile neutral thiol protease from IgG molecule was di

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00907.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Lysozyme activity of macrophages and giant cells in various human granulomas were examined with immunoperoxidase bridge method in tissue sections. Various numbers of epithelioid cells and giant cells of epithelioid cell granulomas of tuberculosis, sarcoidosis and Crohn's disease exhibited intense granular cytoplasmic lysozyme activity. Foreign body granulomas induced with various substances showed negative or faintly positive lysozyme stain. Macrophages and giant cells of aspergillus granuloma associated with thymus hypoplasia and T‐cell depression contained no lysozyme. The results suggest that cell‐mediated immunology plays an important role for the lysozyme synthesis of macrophages in granul

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00908.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Lysozyme activities of skin granulomas of 24 patients in leprosy were studied. Lepra cells of all 15 lepromatous leprosy showed strong lysozyme activity in cytoplasma. In the specimens stained with lysozyme and Ziehl‐Neelsen's carbolfuchsin double stain conspicuous lysozyme activity around M. leprae were observed. One borderline case was negative. Lysozyme of epithelioid cells and giant cells of 10 tuberculoid types were completely negative. These results suggest that lysozyme plays only a small role in the disposal of M. leprae in macrophages and other mechanisms than bacteriolytic function of lysozyme are responsible for the defence against these bacill

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00909.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Liver tissues of 180 autopsy cases of cirrhosis and hepatoma and 285 consecutive autopsy cases of other diseases were studied for liver cell dysplasia correlated with hepatitis B surface and core antigens (HBsAg and HBcAg) in liver cells and sera, and antibody to HBsAg (anti‐HBs) in sera. Liver cell dysplasia was characterietic in cirrhotic livers, particularly with hepatoma. No significant difference was found in age and sex between cirrhotic cases with and without dysplasia. Rate of positive HBsAg in liver cells and sera was significantly high in cirrhotic cases with dysplasia with or without hepatoma. Massive pattern distribution of orcein‐positive liver cells was statistically significant in cirrhotic livers with or without hepatoma, but morphological characteristics of orcein‐positive liver cells could not be correlated in significance with dysplasia and hepatoma. HBcAg showed neither correlation with liver cell dysplasia nor hepatoma. It appears to correlate with active cirrhosis, marked liver cell degeneration and necrosis, and membranous diffuse type HBsAg in liver

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00910.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An autopsy case of a 9‐year‐old Japanese girl revealed a carcinoid tumor originating in the duodenum and hyperplasia of the multiple endocrine organs as manifested by ectopic ACTH syndrome, carcinoid syndrome and giantism. The tumor cells were positive for histochemical argyrophile reaction and two types of secretary granules were identified by electron microscopy. Biochemical assay revealed the production of AGTH and β‐MSH by the tumor cells. Other changes of multiple endocrine organs included acidophll dominant hyperplasia of the pituitary, diffuse hyperplasia of the thyroid, chief cell hyperplasia of the parathyroid, hyperplasia of the islets of Langerhans and the adrenal cortex. This case was considered to be a type of multiple endocrine adenomatosis including carcinoid tumor. The relationship between the carcinoid tumor and multiple endocrine adenomatosis was dis

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00911.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An autopsy case of malignant pheochromocytoma arising in the organ of Zuckerkandl is reported, of which distant metastases were found in the liver and lymph nodes. The biochemical and electron microscopic findings from the tumor tissue showed nor adrenaline‐ secreting type. It was revealed that sex ratio in malignant pheochromocytoma was more prominent in the female, and the frequency of extra‐adrenal origin was higher in malignant pheo chromocytoma than hi benign one from comparative study of reported cases of malignant pheochromocytoma. ACTA PATH. JAP.28: 731–740,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00912.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A 6‐month‐old boy, having suffered repeated convulsive seizures since birth, died of severe epilepsy, the disease remaining unknown. However, when a brother, born after the death of the present case, displayed the same clinical symptoms and was diagnosed clinically as having pyridoxine dependent convulsion, the deceased became suspected of having been a case of familial pyridoxine dependency. Pathologically, bilateral cerebellar hemorrhages were found accompanied by subdural and subarachnoidal hemorrhages. Histologically, neuronal loss and diffuse astrocyte hyperplasia were found hi the brain: Beside marginal gliosis, proliferations of astroglia and glial fibers were found, especially hi the pons, medulla oblongata, and cervical cord, although the fibrillary gliosis may be representative for a physiological intermediate state. Foamy cells were found in the lymph nodes, but not hi the brain. Observed hi the kidneys were substances deposited hi the glomeruli and Bowman's capsules and materials hi the tubular lu

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00913.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A case of disseminated mycobacterial disease caused by mycobacterium sculoflaceum is presented in a three‐year‐old female. Atypical acid‐fast organisms were found in cultures from the tissue of lymph node and bone marrow, gastric juice and feces. Histologically the mesenterlc lymph nodes contained numerous large macrophages which had large numbers of acid‐fast bacilli. Gaseation necrosis was absent. Distinguishing features are the extensive involvement of lymph nodes and bones and the preference for intra‐cellular presence of acid‐fast bacilli.Up to the present in Japan there are only 17 reported cases of atypical mycobacteriosis

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00914.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY