ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03186.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Four cases of yolk sac tumor of the testis and ovary were examined by histochemistry, lmmunohistochemistry, and electron microscopy, and particular attention was directed toward the close relationship between hyaline globules and alpha fetoprotein (AFP). The hyaline globules were easily identified as eosinophilic globular structures located in the cytoplasm of the tumor cell as well as in the extracellular space. They were considered to be of glycoprotein in nature by their histochemical staining property. By an indirect immunoperoxidase method, the majority of intracytoplasmic hyaline globules were positive for AFP. Electronmicroscopically, the hyaline globules appeared as electron dense bodies with no limiting membranes. They were divided into two types by their electron density and inner structure: one is an electron high dense body consisting of homogenous or fine granular materials and the other is a moderately electron dense body composed of fine filamentous structures similar to the basement membrane materials. It is suggested that the former corresponds with the AFP positive hyaline globules produced by the tumor cells of visceral type, while the latter represents the AFP negative globules formed by the cells of parietal type in non‐neoplastic counterpart

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03187.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Sprague‐Dawley rats in a chronic toxicity test revealed specific pulmonary lesions after 180 days of intravenous injection of samples via the tail vein. Microscopically, thickening of arterial walls, periarteritis, edema of perivascular sheath, arteriosclerosis, vasodilatation, arteriofibrosis, abscess and necrosis of arterial walls, embolism and thrombus of small muscular artery or alveolar capillary, and granulomas sometimes accompanying giant cells were found in the lungs. The emboli consisted of hair of the rats, and granulomas with multinucleated giant cell formation and cellular infiltration were prominent around the emboli. The thrombi was characterized by perivascular cuffing, fibrinous and cellular components. These pulmonary lesions are thought to be caused by hair brought from the tail when intravenous injection was carried ou

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03188.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The difference in restoration of injured kidneys according to the time of contralateral nephrectomy was investigated in rats. When the opposite normal kidney was removed immediately or when both kidneys were rendered ischemic totally, the function of the injured kidney or kidneys was rapidly restored and showed almost normal level of blood urea nitrogen as well as normal histology one week after the ischemic damage. But delayed contralateral nephrectomy slowed down the speed of recovery, and the injured kidney did not function completely and showed severe inflammatory reaction in histology four weeks after the injury. It was discussed that retention of some factors like renal hypertrophy factor would cause rapid restoration of the damaged kidney.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03189.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A histological classification of resorbed bone is reported in this paper. The materials used were 426 human bones in autopsy and surgical cases, ranging from 3‐month‐old fetus to 95‐year‐old. The resorbed bones were divided into osteoclasis (osteoclastic resorption) and osteolysis (non‐osteoclastic resorption). Osteoclasis was observed in the cases of development, growth, active stage of granulation tissue, and inflammation, and some cases of malignant tumor invasion. Osteolysis was observed in the cases of senile atrophy, osteoporosis, ischemia, radiation damage, hormonal and chemical effects, non‐active stage of granulation tissue and inflammation, and some cases of malignant tumor invasion. Based on these findings, human resorbed bones can be classified into three histological types: rapid, slow, and static. Such a classification could be certified through the results of animal experiments. A possibility exists that osteoclasis occurs in rapid resorption and osteolysis is in slow and static resorption. Furthermore, it is suggested that osteoclasis is passive resorption and osteolysis i

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03190.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The potassium permanganate method and the unlabeled immunoperoxidase (PAP) method were applied for distinguishing different types of amyloid fibril proteins in conventionally fixed, paraffin‐embedded tissue sections obtained from fifty‐one autopsied cases of systemic amyloidosis and three control cases of well‐analysed fibril proteins. All of the eighteen cases “sensitive” to permanganate treatment, whose amyloid deposits lost completely their affinity to Congo red and birefringence under polarized light, were shown to have AA antigenic determinants by the PAP method. Meanwhile, all of the remaining thirty‐three “resistant” cases, where Congo red affinity and birefringence were retained at various degree even only in minimal areas, were negative for AA antigenicity. This indicated the feasibility of potassium permanganate method for the identification of AA protein based on this criterion of “sensitivity”. Twenty‐eight cases were classified as AA, Aγ, Akor AA+[Ak] the remaining twenty‐three cases were unclassified, and there were some discrepancies between the preliminary clinicopathological classification and the protein nature of the amyloid. It is important to differentiate the types of amyloid fibril protein of individual patients because the expedience of selective therapeutic approaches had been suggested. The two methods applied herein are handy and

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03191.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Light and electron microscopic studies on exocrine pancreas of diabetic dogs with duration of diabetes up to a year induced by streptozotocin were performed. In the pancreatic acinar cells of the long‐term diabetic dogs, atrophy, hyperplastic nodules, and interacinar and interlobular fibrosis were exclusively observed by light microscopy and autophagic vacuoles, lipid droplets, fragmentation of rough endoplasmic reticulum, and decrease or varying size of zymogen granules were much more frequently found by electron microscopy compared with the control. The results might indicate the possibility that insulinopenia causes the injurious effect on exocrine pancreas to produce interacinar fibrosi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03192.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

An autopsied patient with medullary carcinoma of the thyroid and ectopic ACTH syndrome is reported. A microadenoma of pancreatic islet coexisted in this case, which is assumed to be of D cell origin. Immunohistochemical study revealed decreased number of pituitary ACTH cells. Some of them showed Crooke's degeneration. Hormone assay study of tumor tissue and plasma disclosed abnormal ACTH, β‐MSH as well as calcitonin. Somatostatin and Substance P were also demonstrated in tissue. Histologically the tumor showed solid alveolar pattern with a minor part consisting of small cell variant and this histologic variation is discuss

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03193.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A 21‐year‐old woman developed rapid muscle weakness and quickly deteriorating renal function. Pathological findings revealed prominent vasculitis in the muscle and crescentic glomerulonephritis. Combined steroid and heparin treatments could not prevent the development of the renal lesion, but the muscle involvement had soon improved. Although the pathogenesis remains unclear, immune complexes may be involved in this renal les

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03194.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

This report presents an adrenal ganglioneuroblastoma containing several kinds of neuronal peptides. The tumour was found in an autopsy case of a 3‐year‐old girl with clinical manifestation of intractable diarrhea, hypokalemia, achlorhydria, and with elevated levels of plasma vasoactive intestinal peptide (VIP). Immunoperoxidase staining showed many immuno‐reactive VIP‐ containing cells, some somatostatin‐and substance P‐contalning cells on the tumour sections. Ultrastructurally, the tumour cells contained numerous secretory granules that could be divided mainly into two types; one is a small cored vesicle (50‐150 nm in diameter) and the other large electron dense secretory granule (200‐500 nm in diameter). It was suggested that the cells in ganglioneuroblastoma derived from neural crest are closely related to the cells that could differentiate into gut‐hormon

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1982.tb03195.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY