摘要:

Eight beagle dogs of four‐month‐old received both oral administration of N‐Ethyl‐N'‐Nitro‐N‐Nitrosoguanidine (ENNG) and subcutaneous injection of gastrin, and one of them was found to have an annularly infiltrating advanced carcinoma with marked fibrous thickening of the antral wall resulting in stenosis of the antrum (carcinoma scirrhosum) which resembled “Linitis plastica” (Borrmann's type IV carcinoma)

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03171.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The adrenal histology of 107 adult autopsy cases hospitalized within 8 days before death was examined. Thirteen (21.7%) of 60 cases given glucocorticoids within 24 hr of death showed the zona reticularis and lower zona fasciculata composed of clear type cells, while only two (4.2%) of the remaining 47 cases without corticoid administration showed the same histology. The difference was significant (p<0.05), and it was referred to the exogenous corticoids. Administration of adrenalin and/or noradrenalin did not significantly influence the adrenocortical histoloy. The effect of the corticoids depended partly on the diseases from which the patients suffered: the effect was not observed in cases of severe infection or myocardial infarction, but it was shown in cases of cerebral apoplexy and miscellaneous diseases. The above results, on the basis of clear/compact cell morphology, suggest that exogenous glucocorticoids occasionally suppress the pituitary release of ACTH under the stress of dying.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03172.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Proximal portions of the anterior cerebral arteries in rats with long‐term hypertension were electron microscopically studied. The abnormal substances such as granules, vesicles, vacuoles and other membranous structures, relatively homogeneous masses, and basement membrane‐like substances were observed around the medial smooth muscle cells. Basement membrane‐like substances were increased with advancing age and the majority of these substances are thought to be turned from the granulo‐vesicles. Abnormal substances deposited in the media are thought to be “hyalino‐fibrous materials”. The majority of our materials had a clear‐cut border between the media and the adventitia. The subendothelial spaces were slightly distended with fibrillar and/or finely granular substances with age, but neither cellular element nor fibrinoid substance wa

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03173.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Three hundred and sixty cases of breast cancer were collected from among the 63,000 female members of the Radiation Effect Research Foundation (RERF) extended Life Span Study sample which includes atomic bomb exposed women and controls of Hiroshima and Nagasaki. The relationship of these breast cancer cases to A‐bomb radiation was sought, and in studying of 5‐year survival, the following conclusions were obtained concerning its relationship to histopathological findings. The prognosis of the 50+ rad high dose group is the best, followed by the nonexposed group and the low dose group. The apparently better survival may be due to the fact that this group is heavily weighted in favor of those who were younger at the time of the bomb (ATB). There is no specificity of the histologic type of breast cancer in the survivors by dose. Nor is any significant difference observed in the distribution of tumor size and histological grade, though the survival rates of this series are worse than those of usual Japanese women with breast cancer. Cellular reaction is significantly marked in the stroma of carcinoma tissue in the high dose group. Immune reaction is considered to be strong in the affected site of breast cancer in the high dose group and this can be regarded as a finding suggestive of good prognosis. Further extended studies are therefore warren

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03174.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

An autopsy case of sarcoidosis with chronic intrahepatic cholestasis for 2 and a half years was presented. Generalized distribution of noncaseating epithelioid granulomas and positive Kveim test were consistent with sarcoidosis. Histological examination of the liver revealed extensive bile duct destruction similar to that seen in the liver of primary biliary cirrhosis. Destructive cholangitis found in the liver appeared to be responsible for long term intrahepatic cholestasis, and no sarcoid granulomas in the liver were found to destroy any bile duct. The possible relation in pathogenesis of the bile duct destruction between primary biliary cirrhosis and sarcoidosis was discussed.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03175.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

An autopsy case of adult T‐cell luekemia with generalized cytomegalic inclusion disease and pneumocystis carinii pneumonia is reported. Tumor cells had T‐cell characteristics (E‐rosette) and cerebriform nucleus similar to Sèzary cells. Generalized lymphadenopathy, hepatosplenomegaly and an ectopic pancreas in the ileum were found at the time of autopsy. Histologically, leukemic infitration was observed in almost every organ, and perivascular infiltration, vascular invasion were conspicuous findings. Cytomegalic inclusion bodies were observed in most organs(lungs, salivary glands, pancreas, liver, ectopic pancreas, sweat gland, stomach, thyroid gland, pituitary body, etc.). An acute hepatitis, probably caused by cytomegalovirus, was also noted. Presumed correlation of adult T‐cell leukemia, cutaneous T‐cell lymphoma and T‐cell lymphoma w

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03176.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Pathological findings of a 15‐year‐old girl with polyposis of the colon who has subsequently developed primary lymphoma of the brain are reported. The authors consider this case to be a rare example of Turcot's syndrome although the histological typing of the brain tumor is not classical and familial background of the polyposis has not been demonstrated. Literatures on 14 previously reported cases of Turcot's syndrome are reviewed and clinical and pathological findings are summarized. The present case is the second report of Turcot's syndrome associated with lymphoma of the brain and is unique in regard to the age as cerebral lymphoma is extremely rare in the second dec

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03177.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Fine structures of melanosomes incidentally found in the secretory cells of the paranasal sinusal glands associated with nasal malignant melanoma are described and their origin is discussed. It is suggested that these melanosomes in the secretory cells are notde novoproducts but are ingested by cytocrine process.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03178.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A case of a 55‐year‐old Japanese female who died of adenocarcinoma originating from heterotopic gastric pancreas is presented. The autopsy revealed, extensive metastases of bones. Though careful examination was done, other primary focus except that of the stomach could not be detected. In review of literatures, 11 malignant tumors originating from heterotopic gastric pancreas could be found including our c

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03179.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

An autopsy case of a 69‐year‐old male with acute diffuse interstitial fibrosing pneumonitis complicated by bilateral renal cortical necrosis was presented. Autopsy revealed acute diffuse interstitial fibrosing pneumonitis, bilateral renal cortical necrosis, non‐bacterial thrombotic endocarditis, involving the aortic and mitral valves, and some interesting vascular lesions, dissemination of fibrinoid change of arterioles and fibrin thrombus of small vessels in various organs; accumulation of polymorphonuclear leukocytes in the lumen of the smaller interlobular arteries and arterioles of the kidney with cellular infiltration and disintegration of the wall; severe disorganization of the wall with intraluminar and intramural fibrinous exudation in smaller branches of the hepatic artery; diminution and disarrangment of muscle fibers and patchy hyalinization in the media of the renal and interlobar arteries. The inter‐relationship between acute diffuse interstitial fibrosing pneumonitis, bilateral renal cortical necrosis which may be regarded as a ‘hallmark’ of the generalized Shwartzman reaction, and disseminated intravascular coagulation wa

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb03180.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY