ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03218.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

To clarify whether serpentine and amphibole asbestos have different effects on the lung, UICC chrysotile and amosite asbestos were injected intratracheally into hamster lung, and the lungs were examined at 30 min, 1,4,8, and 24 h, and 2 and 4 days after asbestos application by light and scanning electron microscopy. A leukocyte and macrophage reaction appeared at 4 h and increased up to 2 days, and the cell reaction was stronger and more prolonged after application of chrysotile than after application of amosite asbestos. Furthermore, chrysotile induced more prominent cell (leukocytes or/and macrophages) necrosis and alveolar wall thickening. These findings indicate that chrysotile asbestos induces more stronger cell reactions in the alveolar wall, and is more noxious than amosite. Acta Pathol Jpn 42: 707–711, 199

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03219.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Human embryonal carcinoma is thought to be a counterpart of mouse embryonal carcinoma, which has provided useful information for studying early molecular events in murine embryogenesis. A major practical problem in the use of human embryonal carcinoma for molecular pathological studies is the lack of an efficient expression system for foreign genes. The SRα promoter is a fusion promoter containing the SV 40 early promoter and the R segment and part of the U5 sequence of the long terminal repeat derived from human T cell leukemia virus type I. We analyzed the expression pattern of the SRα promoter in human and mouse embryonal carcinoma lines and transgenic mouse tissues. Efficient and stable expression was detected in all cell lines tested, and tissues from all mice of four independent transgenic lines carrying the SRα CAT vector showed a detectable level of CAT expression. These data suggest that the SRα promoter is useful for studies of both human embryonal carcinoma and transgenic mouse tissue. Using this expression system, we are now able to label human embryonal cacinomas with various genes, for example β galactosidase, and follow their fate at the single cell level in nude mice, where xenotransplanted human embryonal carcinoma expresses differentiation capability. Acta Pathol Jpn 42: 712–718

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03220.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We describe histological, immunohistochemical, and ultra‐structural findings in pulmonary eosinophilic granuloma (PEG) from three patients. The specimens were taken by open‐lung biopsy. The lesions of the lung were composed of histiocytic cells, macrophages and eosinophils. The histiocytic cells reacted positively with anti‐S‐100 protein antibody. The histiocytic cells had various types of Birbeck granules in the cytoplasm. The histiocytic cells were histiocytosis X (HX) cells considered to be derived from Langerhans cells. Sporadic mitosis of HX cells was observed. Some HX cells had migrated from the lesions into the alveolar spaces through the alveolar cell layers. In the lesions of PEG, HX cells have self‐reproduction and migration capability. Acta Pathol Jpn 42: 719

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03221.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Proliferative activity of carcinomas arising from salivary glands was analyzed by enumeration of argyrophilic nucleolar organizer regions (AgNORs). The mean numbers of AgNORs in the various tumors were as follows: muco‐epidermoid carcinoma, 2.20; acinic cell carcinoma, 2.51; adenoid cystic carcinoma (ACC), 2.57; carcinoma in pleomorphic adenoma, 1.00 (benign component) and 3.99 (cancer‐bearing area); salivary duct carcinoma, 4.49; polymorphous low‐grade adenocarcinoma, 3.37; sebaceous carcinoma, 2.57; oncocytic carcinoma, 4.63; adenocarcinoma, 4.53. Cells of most tumors showed heterogeneous activity within the same tumor. In mucoepidermoid carcinoma, the mucous cells had suppressed activity in comparison with the epidermoid cells and intermediate cells. In ACC, the activity of the tumor cells increased according to growth pattern in the order tubular, glandular and solid. In carcinoma in pleomorphic adenoma, vigorous proliferative activity was observed in the malignant component, whereas less active cells were seen in the myxoid or chondroid matrix. AgNOR staining was useful for distinguishing benign from malignant regions in carcinoma in pleomorphic adenoma. Our results suggest that mucoep‐idermoid carcinoma, acinic cell carcinoma and ACC, except for that with a solid growth pattern, may be considered as low‐grade malignancies, whereas solid‐type ACC, the cancer component in carcinoma in pleomorphic adenoma and some of the other carcinomas have high‐grade malignant behavior. Acta Pathol Jpn 42:

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03222.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Northeast Thailand has a very high incidence rate of intrahepatic biliary tumors which is believed to closely related to infestation with the liver fluke,Opisthorchis viverrini.This study was conducted to ascertain whether there are any phenotypic differences in such tumors between northeast Thailand and Japan, a country free of liver flukes. Forty one intrahepatic cholangiocarcinomas from patients in northeast Thailand were histopathologically compared with 39 lesions collected in Japan. The proportions of each type of adenocarcinoma in the Thailand cases were similar to those of the Japanese cases except that medullary type poorly differentiated tubular adenocarcinoma was only found in the series from Thailand. Whether the presence of medullary lesions only in the cases from the area of endemic fluke infection implies differences in etiology remains in question. The similarity in the majority of histological types, the inflammatory reactions observed in the bile ducts and the earlier development of tumors in association with parasites suggests that tumor promotion resulting from liver fluke infection rather than quantitative or qualitative differences in genetic alterations is responsible for the high frequency of cholangiocellular carcinomas in northeast Thailand. Acta Pathol Jpn 42: 734–739, 199

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03223.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

An autopsy case of spontaneous rupture of aortic arch through an atheromatous plaque which resulted in pseudoaneurysm is reported. The aorta was involved by severe atherosclerosis with scattered calcifications over the entire surface, and there was a fusiform aneurysm protruding from a transmural tear in the aortic arch. Histopath‐ologically, no evidence of dissection or inflammatory change was noted in the aorta, and no histologic component of the aortic media was observed in the aneurysmal wall. However, degenerative change of cystic and laminar medial necrosis were recognized near the ruptured site. Such localized degenerative change was considered to be caused by circulatory disturbance which originated from disruption of the vasa vasorum due to aortic rupture. Acta Pathol Jpn 42: 740–744, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03224.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We describe a 54‐year‐old woman with primary pulmonary adenocarcinoma showing a characteristic papillary architecture and prominent cilia formation. Immunohistochemically, the tumor cells were positive for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and Leu Ml, and negative for lactoferrin and surfactant apoprotein. An ultrastructural study also indicated differentiation toward bronchial surface epithelial cells. To our knowledge, this type of neoplasm has not been reported as peripheral‐type adenocarcinoma of the lung. Acta Pathol Jpn 42: 745–75

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03225.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

True pulmonary carcinosarcoma (squamous cell carcinoma and chondrosarcoma) originating in the right lower lobe in a 62‐year‐old Japanese male is reported. The tumor, measuring 5.5×3.5×3.5 cm, was markedly necrotic and its apex protruded into the bronchial lumen. Light microscopy showed that the tumor was composed of squamous cell carcinoma with sarcomatous spindle or polygonal cell proliferation and true chondrosarcoma. Immunohisto‐chemically, the cytoplasm of numerous cells of the squamous cell carcinoma component was stained with anti‐cytokeratin (PKK 1) and the cytoplasmic membrane with anti‐epithelial membrane antigen (EMA). Although sarcomatous regions were stained with anti vimentin (vimentin) and no tumor cells were reactive for EMA, a few tumor cells were positive for PKK 1. The cytoplasm of numerous chondrosarcoma cells was positively stained for vimentin and S‐100 protein. Based on these findings, we concluded that the present tumor was a true carcinosarcoma composed of squamous cell carcinoma with sarcomatous regions and true chondrosarcoma Acta Pathol Jpn 42:

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03226.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A 39‐year‐old male was admitted complaining of nonproductive cough and dyspnea on exertion. Death occurred eight months after onset of the symptoms. Autopsy examination showed that the pulmonary trunk and left main pulmonary artery were markedly dilated and completely occluded by a tumor. The tumor had infiltrated into the left upper lobe and mediastinal lymph nodes, and metastatic nodules were found in both lungs and in the left adrenal gland. Small foci of infarction were noted in the lower lobes of both lungs. The tumor cells were of two types; pleomorphic spindle cells and bizarre multinucleated giant cells. Immunohistochemically, they were positive for vimentin, myosin, and lysozyme, but negative for des‐min and muscle‐specific actin. The cytoplasm of the tumor cells was showed by electron microscopy to contain microfilaments, dense bodies, and pinocytotic vesicles. We diagnosed this case as undifferentiated sarcoma of the pulmonary artery. Approximately 100 cases of pulmonary artery sarcoma have been reported. Histopathologicaliy, almost all of the reported cases showed both spindle cells and pleomorphic giant cells, indicating a biologically anaplastic neoplasm. Acta Pathol Jpn 42: 755–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1992.tb03227.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY