摘要:

From the author's hitherto studies on the reticuloendothelial system (RES) it was concluded that the RES is not a single cell system of identical origin, morphology and function but is a group of several types of cells of different origin. From this point of view the heterogeneity of tumors of the RES was studied to reveal the following results. Tumors of the “Reticulo‐endothel” (Aschoff) reveal pictures of endothelioma, while tumors of histiocytes in connective tissue show findings of fibrohistiocytoma. Histiocytes and reticulum cells of lymph nodes are respectively independent cells, and reticulum cells do not partake in the development of histiocytosis or histiocytic sarcoma. Follicular lymphoma is a neoplastic growth of reticulum cells having desmosomes in lymph follicles, and tumor cells of the majority of reticulum cell sarcoma are similar to the cells forming the lymph node anlage in the early fetal stage (lymphoreticular cell). Ewing's sarcoma is considered to be a kind of angioperic

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00880.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Existence of an entity called malignant fibrous histiocytoma of bone was emphasized, based on two of our own cases experienced recently and on previous reports related to this tumor. Histologically the tumor resembles markedly the malignant fibrous histiocytoma originating in the soft part. In addition, an attempt was made to clarify its biological behavior, histological subclassification and criteria to be malignant and differential diagnoses from several other bone diseases which sometimes mimic this malignant bone tumor.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00881.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Langerhans cell granules could be found in atypical histiocytes in lymph nodes of three patients with “atypical hyperplasia” with fatal outcome and one patient with leukemic reticuloendotheliosis. These atypical histiocytes might be derived from immature mesenchymal cells in lymph nodes and the Langerhans cell granules might be induced in these cells by a particular condition. Only one of the Langerhans cell granules seemingly associated with the plasma membrane could be observed in these atypical histiocytes and all of the granules were seen within the cytoplasm. Quite a number of Langerhans cell granules were located near the Golgi apparatus. Several atypical granules very similar to the Langerhans cell granules could also be observed in these atypical histiocytes. These Langerhans cell granules were assumed to be directly derived from the Golgi apparatus and/or derived from the atypical granules which were secreted from the Golgi apparatus. The relationship between the Langerhans cell granules and the microtubules must also be considered, because Langerhans cell granules were found near the centrioles and microtubu

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00882.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Histological analysis was performed on the lesions of the coronary artery and myocardium in accelerated serum sickness of the rabbit. Angiitis was seen to occur on the arterioles in the myocardium and was characterized by fibrinoid necrosis of the media with monocyte accumulation. Myocarditis was observed to be rather prominent in the right ventricle, where monocyte accumulation was associated with scattered degeneration or necrosis of myofibrils. In both lesions, the localization of antigen could hardly be detected in the inflammatory foci, suggesting the irrelevancy between the development of the tissue damages and the permanent deposition of immune complexes. Monocytes were seen to participate in the repair of the tissue injury.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00883.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

N,N'2‐2,7‐Fluorenylenebisacetamide (2,7‐FAA) was administered orally to 34 female, strain AXC/I rats. Nineteen were pretreated with the extirpation of the salivary glands. The remaining 15 rats received no surgical treatment. Six of these 15 unoperated rats developed mammary carcinomas and seven developed tumors at other sites, whereas none of 19 operated rats had mammary tumors but 8 rats had tumors at other sites. No tumor developed in 4 operated control rats that were on normal diet. The results demonstrate that pretreatment with extirpation of the salivary glands inhibited mammary tumor induction in rats by 2,7‐FAA although it did not inhibit induction of other type tumors. The mechanism by which induction of mammary tumors was inhibited is not clear. Ovarian atrophy and hepatic necrosis were observed in both operated and unoperated rats ingesting 2,7‐FAA but did not seem to affect carcinogenesis by the carcinogen. Lower body weight was observed in operated rats but it is not considered to be the major cause of a complete inhibition of mammary tumor

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00884.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Amyloid in freeze‐etened specimen of liver of mice receiving subcutaneous in sodium caseinate was studied morphologically. The convex surface and cross surface of amyloid nodule were noted. The three dimentional structure of the amyloid fibrils which showed felt‐like structure, globular profiles among amyloid fibrils and amyloid bundles were clearly visible. Amyloid bundles enveloped by the cytoplasmic membrane of the Kupffer cell projected from the deeply concave surface of the cytoplasmic membrane into the Disse's space and showed the appearance of stone‐column‐like structure. The amyloid bundles projecting from the invaginated cytoplasmic membrane were closely in contact with the cytoplasmic membrane and deeply rooted in the cytoplasm of the Kupff

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00885.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The lymphoid tissues of 9 monkeys infected experimentally with wild type measles virus were examined by light and electron microscopy. Multinucleated giant cells of the Warthin‐Finkeldey type were found 7 to 11 days after virus inoculation. The giant cells occurred mostly in the germinal center of lymphatic follicles, where they underwent degeneration and disappeared rapidly. Lymphoid and reticular types of giant cells were recognized. The ultrastructural evidence suggested that some of the nuclei contained in giant cells were formed by an aberrant nuclear cleavage. The majority of giant cells, however, were postulated to arise from virus‐mediated cell fusion, although direct evidence of cell fusion was not seen. Peculiar nuclear changes, in which some nuclei and fragments of the outer nuclear membrane were contained in a common outer membrane of the nuclear envelope, were observed in all lymphoid giant cells. Both cytoplasmic and intranuclear inclusions were seen to be composed of viral nucleoprotein strands. The former were detected in all giant cells of both types, and the latter in occasional nuclei, providing the direct evidence that giant cell formation resulted from replication of the vi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00886.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An electron microscopic study of a pineal gland which had been obtained from, a 3‐year‐old girl at autopsy revealed the presence of synaptic ribbon in it. Namely, in some parenchymal cells observed, synaptic ribbons, each of which was ca. 700 nm in length and with synaptic vesicles of up to 60 nm in diameter gathering on the surface, were found in the cytoplasmic area adjacent to the cell membrane. The substructure of the synaptic ribbon, i.e., parallel striae running inside along the longitudinal direction, was definitely observed. There is a hypothesis which has been almost accepted that the mammalian pinealocyte is homologous to the photoreceptor cell of the pineal organ in lower animals, and one of the morphological evidences which supports this speculation is the presence of sensory cell elements in both. Since, this kind of work has been hardly done with human materials, the above finding may offer a meaningful information which discloses a part of the real function of the pineal gland in

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00887.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

An autopsy report of a 76 years old Japanese male, who had suffered from gamma‐HCD, was presented. This Is the fifth case of gamma‐HCD In Japan and this communication is the first autopsy report made on gamma‐HCD in our country. The primary pathological alteration of this disorder is a neoplastic proliferation of atypical lympho‐plasmacytes extending throughout the entire hematopoietic and parenchymatous organs. Pathological characteristics of our case were compared with the same disorders reported in the world lite

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00888.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A 57‐year‐old female with a large retroperitoneal tumor was atutopsied. She showed through the entire course of illness marked leukocytosis with the appearance of immature marrow cells, and this finding was hematologically interpreted as granulocytic leukemoid reaction. An intermittent pyrexia was also seen without infective etiology. The histologic diagnosis of the tumor was liposarcoma of the pleomorphic type. The tumor showed extensive necrosis, but no metastatic invasion was found. So‐called leukemoid reaction appears sometimes together with malignant neoplasms. The majority of these tumors show widespread bone marrow metastases, and without bone marrow invasion they only rarely induce this reaction. Besides it is not common for leukemoid reaction to be evoked by the development of malignant mesenchymal tumors except for malignant lymphomas. The pathophysiologic process of the present case is thought to be a rare occur

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1976.tb00889.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY