摘要:

The effects of surgical removal of the thymus or the administration of antiserum to thymus‐derived lymphocytes on the development of Masugi nephritis were investigated in Wistar rats. While thymectomy at weaning (ATx) had no significant effect on the humoral antibody response to injected rabbit IgG, repeated injections of rabbit anti‐rat thymocyte serum (ATS) suppressed it remarkably. Both treatments did not show morphological evidences that glomerular inflammation and injury were suppressed in the autologous phase of Masugi nephritis. Glomerular lesions in rats receiving the nephrotoxic serum (NTS) one month after ATx (ATx‐1+NTS) appeared to be severer in hypercellularity, mitotic counts, the amount of deposited fibrin‐related substances and crescent formation than those in other nephritic groups. Morphological study of ATS+NTS rats revealed that the glomerular changes were nearly equal to those of NTS‐injected control rats, in spite of markedly suppressed humoral response to injected rabbit IgG and the absence of host IgG along the glomerular capillary walls. ACT A PATH. JAP.29: 333

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00191.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The submucosal heterotopic gastric glands were found in 160 cases (10.7%) of 1500 resected stomachs; 15% in gastric ulcer, 9.9% in gastric carcinoma, 4% in duodenal ulcer and 11% in chronic gastritis. The heterotopic glands were usually found in the distal half of the stomach, diffusely or localized. Macroscopic submucosal tumor was found in 9 (5%) of 160 cases. Although the heterotopic glands were found with an intimate relation to the repeated mucosal damage and subsequent intestinal metaplasia, they had no specific relation to gastric carcinogenesis. ACTA PATH. JAP.29: 347–350, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00192.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Rats were fed on low potassium diets in order to observe the effect of dietary low potassium on the adrenal cortex. The authors clarified morphological changes of the hypofunctional glomerular zone and compared these changes with those of the hyperfunctional glomerular zone.Three weeks after or 2 months after the start of a low potassium diet, slight narrowing of the glomerular zone of the adrenal cortex was observed followed by miniaturization of cells, presence of binuclear cells and an increase of lipid with enlarged lipid drops. Electron microscope mainly disclosed changes of mitochondrial cristae consisting of markedly reduced, enlarged and irregularly dilated cristae with shortening or elongation. Granules appeared in mitochondria. Lysosomes or dense bodies were enlarged. The Golgi's apparatus was atrophied but endoplasmic reticulum did not show remarkable changes. These changes were directly opposite to those of the hyperfunctional glomerular zone noted after a potassium load or seen in sodium deficiency. Consequently, these changes were considered to be the changes of the hypofunctional glomerular zone associated with decrease of aldosterone production. ACTA PATH. SAP.29: 351–362, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00193.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A clinicopathologic and electron microscopic study was performed on 35 cases of primary malignant peripheral nerve tumors, among which 12 developed in association with neurofibromatosis (von Recklinghausen's disease) and further 11 in keeping with anatomically discernible nerves in patients without neurofibromatosis. Depending upon the histologically predominant pattern, these tumors were subdivided into three groups: 23 compact spindle cell, 6 myxoid, and 6 epithelioid varieties of the tumor. The common ultrastructures in three of the 35 tumors were as follows: 1) The cell membranes manifested characteristic infoldings and lamellar configuration. 2) The tumor cell surfaces were coated by occasional basal lamina or homogeneously electron‐dense membranous material. 3) The cytoplasms contained well‐developed organelles and a few neurosecretory‐type granules. Differential points from other soft‐tissue sarcomas were briefly discussed on the histologic basis. ACTA PATH. JAP.29: 363–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00194.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Histologic sections of 68 soft‐tissue sarcomas initially diagnosed as Abrosarcoma were reviewed, and 36 were excluded because of revised diagnosis. The tumors from the remaining 32 patients were analyzed clinicopathologically, and were classifled into two types; the adult type (22 cases) and the infantile type (10 cases). The adult type Abrosarcoma occurred in adults aged 25 to 67 years and consisted of spindle‐shaped Abroblastic cells which formed interlacing bundles accompanied by variable amounts of collagen or reticulin fibers. The infantile Abrosarcoma affected children below the age of seven years in this series and was characterized by proliferation of immature fibroblasts forming indistinct bundles, frequently exhibiting areas of an angiosarcoma‐like pattern and cavernous blood vessels. The authors expressed the view that infantile Abrosarcoma should be separated from adult Abrosarcoma, because between these two types of Abrosarcoma there were marked differences in the histologic feature as well as in the age, sex and anatomical distributions. ACTA PATH. JAP.29: 377–38

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00195.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The present study consists of 651 cases of soft tissue tumors originating in the head and neck area. Among these tumors 628 were benign (96%), while there were only 23 malignant cases (4%). In the benign group hemangiomas showed the highest incidence (47%) followed by tumors of adipose tissue (19%) and those of peripheral nerves (12%). Rare tumors consisted of nodular fasciitis, hibernoma, lipoblastomatosis, glomus tumor, granular cell tumor, and chondroma. The majority of cases in the malignant group were either those of muscle origin or blood vessel origin. Excepting for two cases of rhabdomyosarcoma of the embryonal type and two cases of angiosarcoma, all showed recurrence andlor metastasis and terminated in death. Three cases of liposarcoma of either well‐differentiated or myxoid type had a good prognosis with all three living for 3 or more years without any recurrence. Other malignant tumors consisted of malignant schwannoma, fibrosarcoma, malignant fibrous histiocytoma, alveolar soft part sarcoma, and chordoma. The age, sex, anatomical location, and differential diagnosis have also been described. ACTA PATH. JAP. 29: 389 ‐ 408, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00196.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Thromboplastic and Abrinolytic activities in various organs of congenitally athymic nude mice were estimated. These activities varied from one organ to another and the organs were divided into six groups of possible combinations of these activities. The lung revealed high thromboplastic and high Abrinolytic activities, while the liver showed low thromboplastic and low Abrinolytic activities. The pattern of distribution of these activites in various organs of nude mice was almost similar to that of rats and mice with normal thymus. No plasmin activity was found in all organs. ACTA PATH. JAP.29: 409–411, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00197.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The silver positive cells of the exocrine pancreas and primary pancreatic cancers were studied with the Grimelius silver stain and the Fontana‐Masson technique. In the pancreas, cells containing black granules with the Grimelius method, which at the same time react negative to Fontana‐Masson, are considered argyrophil. These cells were present in the basal portion of some of the acinar tissue and in the ductal epithelia, as well as in the A cells of islets. The incidence and distribution of these argyrophil cells were also studied in a variety of ductal lesions. In the so‐called ductal proliferation numerous numbers of positive cells were found. Argyrophil cells were frequently situated in the basal portion of ductal squamous cell metaplasia. In goblet cell metaplasia the numbers were few, and less than in normal ducts. We concluded that the distribution and incidence of argyrophil cells in the ductal epithelia is related to chronic pancreatitis, and in particular to regenerative processes. The incidence of argyrophil cells in primary pancreatic cancer, excluding islets cell origin, was 18 per 41 cases (43.4%). We considered them pancreatic cancer with argyrophil cells. ACTA PATH. JAP.29: 413–41

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00198.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The cocarcinogenic effects of asbestos are presented. In lung carcinomas induced in mice, the number of carcinomas and the time of detection of the Arst carcinoma per tumor‐bearing animals were greater and faster in the group with chrysotile plus MNU than either chrysotile or MNU alone. This suggested that chrysotile asbestos had a promoting or cocercinogenic effect on some carcinogens in the respiratory tract. In the group treated with chrysotile alone, a tumor was found in the right pleural cavity at 15 months. This tumor microscopically was similar to the biphasic form of the human diffuse mesothelioma. Microvilli, basement membrane, and junctional apparatus were seen by electron microscope, but other cytoplasmic organelles of the tumor cells were relatively scanty. Two peritoneal tumors developed in gastric and intestinal serosa at 11 and 12 months. Light and electron microscopic studies suggested that the tumors were probably myosarcomas or Abrosarcomas. ACTA PATH JAP.29: 421–433, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00199.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A4‐moth‐old male infant predisposed to allergic dermatitis acquired widespread eczema vaccinatum by contacts with a recently vaccinated sibling. He died of acute purulent peritonitis following a perforation of multiple duodenal ulcers. Fluorescence immunocytochemical and electron microscopic studies on the skin lesions revealed the presence of viral antigens and numerous virus particles compatible morphologically with those of the mature form from the same batch of smallpox vaccine given to the sibling. A large number of virus particles in the developmental form were also predominantly scattered in the cytoplasm of cells at the stratum malpighii of the epidermis as well as in neutrophils and macrophages in the skin lesions. The virus isolation from the skin lesions was done by using the HeLa cells and the human embryonic lung fibroblasts. No abnormal laboratory data were noted in immunoglobulins. On the basis of atrophy of the thymus and other lymphatic tissues and an appearance of large pyroninophilic cells in association with blastoid transformation, the authors discussed a possible participation of the disturbance of cellular immunity secondary to the virus infection in the development of the disease. ACTA PATH. JAP.29: 435–455,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00200.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY