摘要:

Fourteen autopsy cases of paraquat poisoning were studied. Seven of the eight patients who died within 4 days after the ineestion of paraquat showed hepatocytic injury, and three of them revealed bile duct injury. Hepatocytlc injury was similar to that of carbon tetrachloride intoxication. Bile duct injury consisted of epithelial changes of the bile ductules and bile ducts. Cholestasis in the bile ducts was produced by the injury. The affected blle ductules and ducts had hydropic and necrotic epithelium, associated with the infiltration of neutrophils and histiocytes in the lntraductal and periductal tissues. The severity of bile duct injury increased gradually from the bile ductules to the septal bile ducts. The extrahepatic billary tract showed the same injury as the septal bile ducts in one case. It is considered that bile duct injury was produced by a direct corrosive effect of paraquat. Five of the six patients who survived more than 8 days revealed intrahepatic cholestasis, the pathogenesis of which was not clearly understood.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03276.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

An immunopathological study was carried out on subcutaneous nodules (rheumatoid nodules) biopsied from 16 patients with rheumatoid arthritis. Sixteen rheumatoid nodules were histologically classifled into three stages; the 1st stage (acute inflammatory stage, 3 cases), the 2nd stage (granulomatous stage, 10 cases), and the 3rd stage (scar‐formed stage, 3 cases). In necrotic or granulation tissue of the nodules in the 3 stages, immunofluorescent analysis using FITC‐labeled rabbit anti‐human immunoglobulins, β1C, and flbrinogen serum γ‐globulins and FITC‐labeled aggregated human IgG gave results that were strongly positive in the 1st stage, moderately positive in the 2nd stage, and only slightly positive or almost negative in the 3rd stage. Acute or chronic thrombotic endoarteritis was observed around rheumatoid nodules in 6 out of the 16 cases. Among them, 2 cases of the 1st stage showed acute thrombotic endoarteritis with marked infiltration of neutrophils in the wall, and 2 cases of the 2nd and the 3rd stages respectively showed chronic endoarteritis with organi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03277.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Eight cases of adenomatoid tumors of the male genital tract are presented. Histological, histochemical, and electron microscopic studies were performed and an approach to a new classification of adenomatoid tumors was discussed. The number of so‐called adenomatoid tumors of male genital tract reported in Japan adding our eight cases totalled 60 cases. These were classfled as follows; 10 cases of mesothelial (superficial) type and 50 cases of adenomatoid (profound) type. Besides these, 8 cases of mesothelial type were reported in foreign literatures. Three cases of adenomatoid tumors of the uterus and a case of epididymitis chronica with reactive proliferation of mesothelial cells were also examined. As a result of these investigations, it is suggested that the histoQenesis of the so‐called adenomatoid tumors is composed of two different processes: i.e., mesothelial type arising from serosal mesothelial cells and adenomatoid type arising from immature Miillerian mesenchymal tis

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03278.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Spontaneously hypertensive rats develop periarteritis nodosa spontaneously with high incidence. Immunohistology of periarteritis nodosa reveals that fibrinogen constantly deposits in the wall of the diseased artery in exceptional combination with IgG but never with complement (Ca). This fact suggests that periarteritis nodosa in spontaneously hypertensive rats may not be arteritis of immune complex type. Permeability test using mainly peroxldase as a tracer demonstrates that increased arterial permeability in spontaneously hypertensive rats is recognizable since 4 to 6 months of age without sexual difference in its intensity. In male spontaneously hypertensive rats periarteritis nodosa is observed in 6 of 11 and the arterial permeability increases more pronuncedly in the positive group, whereas 5 female spontaneously hypertensive rats of various ages are free from periarteritis nodosa irrespective of high arterial permeability. Therefore, high arterial permeability does not always lead to regular development of periarteritis nodosa, especially in female spontaneously hypertensive rats.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03279.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The existence of four types of cells in the glomerular outgrowths from both normal and nephritic rabbits was confirmed, and their characteristics by phase contrast, scanning electron, and transmission electron microscopy are described. Type I (arborized), Type II (fusiform), Type III (round), and Type IV (paving stone‐like) cells presumably originate from visceral epithelial cells, mesangial cells, monocpes, and parietal epithelial cells of Bowman's capsule, respectively, though conclusive evidence is still lacking. The Type III cells, unlike the other types of cells, have a remarkable phagocytic capacity as well as Fc and C3 receptor

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03280.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

In the autologous phase of nephrotoxic nephritis in the rabbit, many round (Type 111) cells appeared in the glomerular outgrowth. They had receptors for Fc and C3 and a pronounced phagocytic capacity for carbon. The number of Type 111 cells in the glomerular outgrowth from rabbits 8 days after injection of nephrotoxic serum (NTS‐8) was higher than that of NTS‐10 or ‐15. In contrast, they were rarely observed in the outgrowth of glomeruli from normal and NTS‐3 rabbits. The Type I1 (fusiform) cell, a type of intrinsic glomerular cell, was also increased earlier and more markedly in NTS‐8, ‐10, and ‐15 than in normal and

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03281.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Liver tissues obtained from 78 human fetuses between 5 weeks and 10 months of gestation were observed with light and electron microscope. In the third month of gestation hepatic megakaryocytopoiesis reached the maximum level and then appeared to decline. At the maximum level immature to mature megakaryocytes were usually smaller than those from adult bone marrow. They were observed between growing liver cells, within hepatic sinusoids and in the mesenchyme surrounding the liver parenchyma in the given order of frequency. Immature megakaryocytes were characterized by the presence of both demarcation vesicles or tubules and a few small round specific granules. The nucleus was mononuclear but frequently indented. With cell maturation, the megakaryocytes were stained intensely by PAS‐technique. The nuclei were multilobulated. Large cytoplasm was dominated by numerous specific granules and well‐developed demarcation membrane system. Some megakaryocytes passed through the sinusoidal wall and possibly to hepatic sinusoids. These observations indicate that the main site of hepatic megakaryocytopoiesis may be extravascular and more likely between liver cells. Small megakaryocytes in fetal livers are discussed in relation to the occurrence of similar megakaryocytes in various blood dyscras

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03282.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A total of 160 Sprague‐Dawley rats averaging in body weight, were used for hlstopathological and biochemical studies of toxicity of bis (tri‐n‐butyltin) oxide (TBTO). Short‐term effects and long‐term effects were examined. LD50 of TBTO by gastric tubing was 197 mg/kg. The effects of a single dose of TBTO were transient, and rapid recovery followed. TBTO at a a single dose of 100 mg/kg, or a total dose of 390 to 780 mg/kg In 13 weeks, or 780 to 1,560 mg/kg in 26 weeks, caused adrenal hypertrophy, flattening of the thyroid epithelium and atrophy of the thymus and lymph nodes. A single or repeated administration induced swelling and vacuolatlon of aldehyde‐fuchsin‐posltive cells in the adenohypophysls. The lmmunohistochemlcal stainability of the cytoplasm of ACTH‐cells was markedly depressed 24 hours after TBTO treatment, and that of the cytoplasm of TSH‐cells was enhanced. Analogous an inverse relationship was also manifested in the hormonal levels of serum: levels of Cortisol were elevated, while those of T‐4 and

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03283.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

In addition to the morphological examination, the measurement of the content of corticosteroids was done in aldosterone‐producing adenoma. Histologically, the adenoma consists of four types of cells. The major component of the adenoma was clear‐type cells. In this type of cells, the activities of 3β‐hydroxysteroid dehydrogenase and glucose‐6‐phosphate dehydrogenase showed weakly positive. The fine structure was characterized by numerous lipid vacuoles and poor organellae. On the contrary, intermediate‐ and compact‐type cells revealed higher than moderate activities of these enzymes. Moreover, marked development of smooth endoplasmic reticulum and mitochondria was noted. Zona glomerulosa‐type cells were observed only in a small part. The content of aldosterone and corticosterone in aldosterone‐producing adenoma was significantly larger than those of the other type of adenoma. A tendency of positive correlation between the increase of compact‐type cells and content of aldosterone was found. The cell origin of this aldosterone‐producing adenoma and functional role of clear‐ and compact‐type

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03284.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Invitrotransformation of brain cells cultured from various age rats by human adenovirus type 12 (Ad‐12) was studied. In cultured brain cells, five cell types could be identified light microscopically. In astrocytes, Ac‐2 and Ac‐1, astroprotein was demonstrated by immunofluorescence technique. In the former, intracytoplasmlc microfilaments were recognized by electron microscopy. Undifferentiated cells (Ud), ependymoglioblasts (EGb) and Ac‐1, grew prominently in cultures from young animals or of early passage levels. Ac‐2 and fibroblasts were prominent in cultures from aged animals or of late passage levels. Transformed foci appeared within about 20 days after Inoculation of Ad‐12 and often located in close association with the sheets of Ac‐1. Transformed cells morphologically resembled EGb or transitional cells from EGb to Ac‐1. Transformation rate was high in cultures from young animals or of early passage levels. Subcutaneous transplantation of these cells into newborn rats procued tumors whose histology was similar to Ad‐12‐induced rat brain tumor. T‐Ag were detected both in transformed and transplanted tumor cells. It was concluded, that the target cells of Ad‐12 in vitro correspond with immature brain cells (EGb and/or transitional cells

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1980.tb03285.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY