摘要:

Coronary artery spasm is undoubtedly one of the causative factors of ischemic heart disease, particularly variant‐type angina pectoris and myocardial infarction, but the disease mechanisms involved are still unclear. The present review describes the clinical background of coronary artery spasm in relation to ischemic heart disease, including a brief history of studies in this field, and also suggests future guidelines for experimental investigations based on the characteristics of coronary artery spasm, focusing particularly on data we have obtained in our laboratory from studies of cholinergic constriction. The pig may be a suitable animal in which coronary artery spasm could be provoked with cholinergic agents following endothelial denudation. The use of such large animals would allow the study of spastic arterial segments by various methods with angiographic confirmation. After endothelial denudation it is possible that phenotypic changes in cholinergic receptors might occur in smooth muscle cells, and that such changes might remain even after endothelial repair. Acta Pathol Jpn 41: 865‐873, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01631.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The authors confirmed the presence of endocrine cells for the first time in a normal breast as well as in a non cancerous lesion of the breast. One hundred and eighty eight blocks of normal breast tissues in 44 cases and 74 blocks of non cancerous lesions in 35 cases were examined. Argyrophil cells were found in one block from a normal breast and in one block from a phyllodes tumor. Argyrophil cells in the normal breast showed positive reaction to anti‐endocrine granule constituent (EGC) antibody with immunohistochemical method. Argyrophil cells found in the phyllodes tumor gave positive reaction to both anti EGC and anti‐serotonin antibodies. The present study is thought to be the first report in the literature of serotonin‐positive cells in a non‐cancerous breast lesion, a phyllodes tumor. Acta Pathol Jpn 41: 874‐

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01632.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Human autoantibody to Sertoli cells was detected in normal human sera. This IgM type autoantibody was undetectable during the neonatal period and was found in 11.5% of 365 serum samples taken from adult healthy persons of both sexes. This human autoantibody to Sertoli cells exhibited quite the same target‐organ specificity and multi organ reactivity (salivary gland ductules, pancreatic intercalated duct, renal lower nephron, pituitary acidophilic cells) as those of the murine monoclonal autoantibody (IgM class) to Sertoli cells (TM‐1: WHO registered code T43). The TM‐1 monoclonal antibody could recognize testicular antigens with molecular weights of 67,000 and 23,000 in Sertoli cells, and had already been demonstrated capable of inducing murine experimental spermatogenic disturbance when administrated together with murine monoclonal autoantibody to seminiferous tubular basement membrane (TNI 2: WHO registered code T44). These observations may suggest that human spermatogenic disturbance could be easily induced by the multi‐organ reactive autoantibody to Sertoli cells even in healthy individuals under particular conditions where this autoantibody can be allowed to reach the target Sertoli cells across the barrier of seminiferous tubular wall by either autoantibody to seminiferous tubular basement membrane or other toxic damage. Acta Pathol Jpn 41: 879‐

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01633.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

We carried out an electron microscopic study of eosinophilic intracytoplasmic inclusions in the subthalamic neurons in a case of atypical motor neuron disease. These inclusions were identical in light microscopic morphology and staining characteristics to Bunina bodies. Ultra‐structurally, most of the intracytoplasmic inclusions observed were divisible into two different types (I and II). Type I inclusions had features essentially identical to those of Bunina bodies demonstrated previously in the anterior horn cells in cases of motor neuron disease; they consisted of electron‐dense, granular material without a particular limiting membrane and often contained a number of translucent areas with entrapped cell organelle like structures. Type II inclusions were very similar to structures known as multilaminated bodies; at their margin, they sometimes showed continuity with the cisternae of endoplasmic reticulum. The remainder of the inclusions were considered to be transitional forms between these two types, and some of them showed the respective features of both types I and II. These findings suggest that Bunina bodies are of endoplasmic reticulum origin. Acta Pathol Jpn 41: 889‐894,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01634.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The patient was a 46 year old male hemophiliac who died of acute mycobacterial meningitis associated with AIDS (acquired immune deficiency syndrome). Autopsy revealed severe basal meningitis which was characterized by an infiltration of numerous polymorphonuclear leukocytes. Severe mural inflammation of the subarachnoid arteries was noted, and innumerable acid‐fast bacilli were demonstrated. Epithelioid cell granulomas were not found in the meningeal lesion. The lungs, liver, spleen, and bone marrow contained many epithelioid cell granulomas with caseous necrosis. Massive proliferation of swollen histiocytes could not be identified in any organ. The absence of epithelioid cell granulomas in the meningeal lesion indicate a severe impairment of cell‐mediated immunity in the patient; this anergic type of lesion is one of the characteristics of tuberculosis occurring in association with terminal AIDS. Acta Pathol Jpn 41: 895‐899,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01635.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

A case of cytomegalovirus (CMV) vasculitis in the intestine of a patient with acquired immune deficiency syndrome (AIDS) is reported. The distal jejunum and ileum had multiple well‐demarcated mucosal ulcers and microscopic examination revealed an unusual, exuberant fibroblastic proliferation in the ulcer base. Amidst these fibroblasts, there were several small blood vessels of which the endothelial cells contained cytomegalic inclusion bodies. The lesion showed a Kaposi's sarcoma‐like appearance, but spindle cells were negative in immunostaining for factor VIII related antigen or Ulex europaeus agglutinin 1. Although the CMV infection was observed in almost all organs, the exuberant fibroblastic proliferation seen in the intestine was not found in other organs. This lesion might represent a peculiar reaction of the immunologically compromised host to the CMV in the intestinal blood vessels. Acta Pathol Jpn 41: 900 904, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01636.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

A case of poorly differentiated adenocarcinoma of the stomach with unique histological features is reported: in addition to characteristic adenocarcinoma cells, a large number of tumor cells contained bright eosinophilic and argentaffin granules in their cytoplasm. On routine histologic examination, the latter cells closely resembled the endocrine cells present in the normal human gastrointestinal tract, although the granules were distributed throughout the cytoplasm and did not show any polarity, which is usually subnuclear in normal endocrine cells. Imuunohis‐tochemical studies demonstrated positive staining for lysozyme, CEA, gastrin and HCG. Electron microscopic examination revealed cytoplasmic neurosecretory granules, and some tumor cells were found to contain both secretory granules and mucinous material within the same cytoplasm. These neoplastic endocrine cells presumably originated from primitive digestive system elements capable of differentiating towards both endocrine and mucus‐secreting varieties. Acta Pathol Jpn 41: 905‐910,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01637.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Adenomatous hyperplasia of the liver is known as a preneoplastic or early developmental stage of hepatocellular carcinoma, in which overt malignant foci occasionally develop. We have recently experienced an autopsy case (a 70‐year‐old male) of liver cirrhosis with hepatocellular carcinoma and two nodules of adenomatous hyperplasia. The latter two nodules contained several microscopic foci of moderately differentiated hepatocellular carcinoma. There were a number of tumor microemboli in portal vein branches within areas of adenomatous hyperplasia in addition to areas surrounding cirrhotic liver, some of which grew into the parenchyma of adenomatous hyperplasia and cirrhotic regenerative nodules. These findings and the fact that adenomatous hyperplasia contained portal tracts including portal venous branches, suggest that malignant foci in adenomatous hyperplasia of the liver in this case might represent metastases from hepatocellular carcinoma in other parts of the liver via the intrahepatic portal venous system. Acta Pathol Jpn 41: 911 915, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01638.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

A rare case of splenic epidermoid cyst (SEC) of the pancreas discovered in a 32‐year‐old Japanese female is reported. The lesion, 5x6cm in size including caseous material and serous fluid in the lumen, was discovered by ultrasonography and computed tomography at the tail of the pancreas and was easily removed. Histopathologically, the cystic wall consisted of three components: the inside was lined by mature squamous epithelium with keratinization, the middle layer consisted of splenic pulp with a sinus structure, and the peripheral layer was dense fibrous connective tissue in which some involutional pancreatic ducts and islets were recognized. The literature about SEC of the pancreas is discussed in comparison with other types of epidermoid cyst including lymphoepithelial cyst and dermoid cyst in the pancreas. Acta Pathol Jpn 41: 916 921, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01639.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Two cases of coexisting mature teratoma and thecoma are reported. In Case 1, a 36 year old woman presented with severe genital bleeding and an ovarian tumor, 12x9 cm in size, was found. In Case 2, a 48‐year‐old postmenopausal woman presented with severe lower abdominal pain and an ovarian tumor, 15x11 cm in size, was detected. Macro‐scopically, the resected tumors of both cases showed a unilocular cystic tumor adjacent to a solid tumor. Microscopically, the cystic tumors were composed of cutaneous tissues and the solid tumors consisted of spindle cells with lipid rich cytoplasm, arranged in interlacing bundles. The cystic tumor and the solid tumor were completely separate and no transitional features were recognized histologically. Acta Pathol Jpn 41: 922‐92

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1991.tb01640.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY