摘要:

Pathogenic behaviors ofShigellaandShigella‐likegroup of enteropa‐thogenicEscherichia coli, which are equally causative organisms in bacil‐lary dysentery, were demonstrated in experimental infection in monkeys and other experimental systems.From these observations it is concluded that virulent strain ofShigellaand enteropathogenicE. colishow specific affinity to epithelial cells and their invasion into those cells of colonic mucosa in the initial stage is an indispensable factor by which the later process of the infection can be established.The importance of hypersensitivity as a factor to determine the development of bacillary dysenteric colitis was emphasized. ACTA PATH. JAP. 20: 261 ‐ 27

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03071.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Studies were made with main emphasis on changes in the renal interstitium, using 301 cases including various forms of metabolic disease, drug‐induced nephritis, viral disease, scarlet fever, delayed sepsis, obsolete pulmonary abscess, various cases in the state of prolonged sensitization, various types of collagen disease and glomerulonephritis. Pyelonephritis was excluded from this study, because it was caused directly by bacterial infection.The results induced from the study are that there are two types of interstitial nephritis: the primary type which originates in the interstitium by way of the vascular system and the secondary type which first develops degeneration or necrosis in the tubular epithelium, being followed by an interstitial inflammation. In the former the changes of the interstitium are a simultaneous affair with those of the glomeruli. When diseases are in an allergic hyperergic condition, changes of the glomeruli are more conspicuous than those of the interstitium, though the lesions are diffuse and intense in both. With the state of prolonged sensitization of the diseases or in collagen disease, inflammatory processes become localized within a part of each glomerulus and focalized also in the interstitium, forming such lesions as collected lymphocytic infiltration, occasional lymph follicles or focal fibrosis with proliferation of capillaries and small vessels. When these focalized lesions are seen markedly in the interstitium, an introduction of the morphological expression “Primary interstitial nephritis” is necessary. In typical chronic primary interstitial nephritis, though small in number, the focal interstitial lesions stand out prominent, the glomerular changes being minimal and hyperazotemia is clinically manifest or may become a cause of death. ACTA PATH. JAP. 20: 279–30

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03072.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

A high incidence of renal lesions (120 of 164) was confirmed in Mastomys. As high as 86.4% of the tumor‐bearing cases developed renal lesions, while 50.8% of animals without tumors were involved by such lesions. Glomerulonephritis was the most frequent with an incidence of 88.3% of the cases. An increase of the mesangial matrix was the initial form. Almost one‐third of glomerulonephritis cases were complicated by pyelonephritis and hydronephrosis. Tumor‐bearing cases had more advanced lesions in an average severity, although a half of them had only mild changes. Immunohistochemical studies revealed localization of globulins and beta 1C along the walls of the glomerular tufts suggesting deposition of immune complexes. Nodular homogenous deposits in close contact to the basement membrane were ultrastructurally evidenced in the glomeruli. A tiny adenoma was found in a male case with stomach tumor. ACTA PATH. JAP. 20: 311 ‐ 32

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03073.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

In 1959, the Miyako islands, Okinawa were continually attacked by typhoons and the natives who had lost their agricultural products subsisted largely on cycads. Since cycad compounds have a carcinogenic effect in a variety of laboratory animals, it is possible that they could become carcinogenic agents after ingestion in humans. The present authors attempted a statistical survey of the mortality from cancer during the years 1961 through 1966 to follow‐up the tumor incidence among these natives. Mortality from stomach cancer in the Miyako islands was lower than in interior Japan. Although there was no significant difference in death rate for hepatoma between the two, it was higher in TJeno and Irabu district. The death rate for liver cirrhosis in the Miyako islands was higher than that in interior Japan, especially it was most prominent in Tarama district. These statistical results in each district was not proportional to the rate of ingestion of cycad material during the time of famine. However, most natives in these islands have long used this plant as a food before and during World War II. High death rate for liver cirrhosis in the Miyako islands may have some correlation to such a habit of the natives. Symptoms of an acute toxicity of cycad in humans were also studied on 18 patients. ACTA PATH. JAP. 20: 327 ‐ 337, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03074.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Ultrastructural observation has been made on a cirrhotic liver in a 44‐year‐old man with a known history of heavy whisky consumption for the past 20 years. Observations were mainly focussed on the mitochondrial changes and perinuclear amorphous granular bodies presumably identical to the so‐called Mallory's alcoholic hyalines.The mitochondrial changes consisted of (1) gigantism and disfiguration of the mitochondria, (2) presence of intramitochondrial crystalline inclusions, (3) aggregation and disorientation of microtubular cristae, and (4) increase in the number and size of mitochondrial granules.The perinuclear amorphous granular bodies were limited in part by an incomplete membrane outlined by scattered electron‐dense bodies suggestive of altered lysosomes, and contained irregularly distributed filamentous structures that were often paired not unlike the fragmented cristae of mitochondria. It is emphasized that these structures are consistent with the so‐called Mallory's alcoholic hyaline bodies and that they make up one of the forms described as focal cytoplasmic degradation.Since no definite evidence of transitional forms has been observed, the relationship between the altered mitochondria and Mallory's hyaline bodies has not been established. ACTA PATH. JAP. 20: 339

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03075.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The foam cell of xanthelasma of the stomach is lipid laden histiocyte having a number of microvilli measuring approximately 0.1 μ in width and 2–3μ in length. In the cytoplasm, a number of lipid particles of vacuolar type and osmophilic type were seen but the former type was more numerous.Lipid particles were also observed in the plasma cells, pericytes and smooth muscle cells of the lesion and all these particles were of vacuolar type. It was estimated that the lipid accumulation in the cytoplasm in case of xanthelasma of the stomach is not entirely caused by phagocytosis but by localized change in metabolic pathway of lipid. It is most likely that lipid consists of various constituents including from neutral fat to fatty acids. ACTA PATH. JAP. 20: 357–363,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03076.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

An autopsy case of Kasabach‐Merritt syndrome in an infant has been reported. Clinically, multiple congenital subcutaneous hemangiomata, severe thrombocytopenia, considerable anemia and abnormal blood cells in the peripheral blood were observed. Postmortem examination revealed remarkable extramedullary hematopoiesis in various organs, hyperplasia of bone marrow and alveolar and glomerular dysplasia. Discussing these findings, we have reached an assumption that Kasabach‐Merritt syndrome may be a state of developmental anomaly of angiomesenchyma. ACTA PATH. JAP. 20: 365–378,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03077.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The clinical history and pathological findings in a case of ataxia‐telangiectasia are reported.Clinically the case showed characteristic neurological manifestations and telangiectases with frequent respiratory infections. Absence of IgA immunoglobulins was demonstrated. There is parental consanguinity and a younger sister is also affected.The significant histological abnormalities in the central nervous system were a severe degeneration of the cerebellar cortex. Both lungs were fibrotic with old bronchopneumonia and bronchiectasis. There were atrophy, and perhaps hypoplasia of thymus, spleen and lymph nodes. ACTA PATH. JAP. 20: 379 ‐ 385, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03078.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Light and electron microscopic observations of interstitial cell hyperplasia of testis were made. Some of the hyperplastic interstitial cells in the first case were so atypical that tumorous growth was considered to occur in part.Electron microscopically, the cytoplasm of hyperplastic interstitial cells were filled with vesicles. A large amount of lipochrome pigment granules were found in hyperplastic interstitial cells of the first case, but only scarcely in those of the second case. The pigment granules were assumed to have been induced from mitochondria. Lamellar structures, originating from endoplasmic reticulum, were occasionally found in cytoplasm. Bundles of fibrils were seen scattered in the cytoplasm of some interstitial cells. The bundles were rarely encountered within the lysosomal or pigmental granules, though they were very scarce. They showed occasionally a large aggregation, which might be a precursor of Reinke crystalloid. ACTA PATH. JAP. 20: 387–398, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1970.tb03079.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY