ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01957.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01958.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY

摘要:

When the rabbits were sensitized intra‐venously against bovine red blood cells and a provocative injection of the same antigen was given by way of the portal vein or the hepatic artery, focal necrosis of the hepatic cells occurred in some instances and rather conspicuous periportal exudative process were seen in association with portal thrombosis and fibrinoid swelling of the hepatic arterial walls. Biochemical changes in the rabbit's sera indicated that the functional damages thus induced in the liver were slight.Similar but far more prominent changes were observed in the liver when anti‐rabbit blood cell guinea‐pig sera were introduced in the same way. Intravascular fibrin deposition was thought to be responsible for the development of the hepatic damages. The functional damages to the liver as reflected in the biochemical data of the rabbit's blood, were severer than in the first experiment and took a longer course until certain similarity with human liver cirrhosis became apparent.The findings may indicate that anaphylactic phenomena can play a role in the pathogenesis' hepatitis in human

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01959.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY

摘要:

Die Verfasser beabsichtigten durch die anatomsiche Beobachtung der 226 Herzen mit Anomalien des arteriellen Herzendes (117 isolierte Ventrikelseptum defekte und 109 Fallostsche Tetrade) zur Erkla'rung der Morphogenese dieser Missbildungen beizutragen. Diese Herzmissbildungen kommen mit dem VSD, der Rechtsposition der Aorta und der Pulmonalstenose etc vor. Nach unserer Untersuchung, in der Regel je weiter vorn der VSD sitzt, desto geringer ist die Rechtsposition der Aorta (isolierte VSD). Im Gegensatz, je weiter hinten der VSD sitzt, desto starker ist die Rechtsposition der Aorta und dabei wird das Herz mit Pulmonalstenose begleitet (Fallotsche Tetrade). Diese Beziehung versteht man morphogenetisch als die Folge der abnormen Kreuzung der aortalen und pulmonalen Blutströme in der Frühembryonalzeif, wobei die Kreuzung beider Ströme, die normal im Truncusteil mit richtigem Winkel geschieht, im Bulbusteil mit scharferem Winkel geschieht. Je grosser die Distanz zwischen dem Kreuzungspunkt und der Ostiumebene war, desto weiter hinten kommt der VSD vor und desto grösser ist der Grad der Rechtsposition der Aorta, begleitet mit Pulmonalstenose (Fallotsche Tetrade). Bei der gengensätzlichen Bedingung kommt isolierter VSD vor. Diese morphogenetischen Beziehungen und das Vorkommen der verschiedenen Ubergängen zwischen beiden Typen wurden durch anatomische Verhältnisse unserer missbildeten Herzen g

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01960.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY

摘要:

The terminal distribution of the hepatic artery of the human liver was examined by arterial injection of india ink and serial sectioning. The branches of the hepatic artery form capillary networks around the bile duct in the portal tract, from which the capillaries (terminal venous branch) arise and connect with sinusoids at the most peripheral zone of the liver lobules. Evidence of direct anastomosis between the hepatic artery and portal vein inside the portal tract or presence of “innere Pfortaderwurzeln” as well as the intralobular arteriole was not demonstrated.The authors also studied the hepatic changes caused by interruption of the portal blood supply to the liver lobule. It was demonstrated that the portal tract and its components as well as several layers of liver parenchymal tissue around the portal tract are nourished from blood via the peribiliary capillary plexus and thus remains unaffected by portal obstruction, while other parts of the liver lobule will undergo coagulation necrosis.Based on the present investigation, the authors believe that the hepatic artery plays the main role in the nourishment of the bile duct while it has little to do with that of the liver lobule, except for the most peripheral layers of the liver lobules adjacent to the portal ar

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01961.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01962.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY

摘要:

Book Reviews in this ArticleErzeugung von Krunkheitszuständen durch dus Experiment. Teil 12. Tumoren I. as Handbuch der experimentellen Pharmakologi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1966.tb01963.x

出版商:Blackwell Publishing Ltd    

年代:1966

数据来源: WILEY