摘要:

Diffuse proliferative glomerulonephritis was induced in the rabbit with injection of goat nephrotoxic serum, and cell dynamics in the glomerulus were quantitatively investigated. The mean total cell number of a normal glomerulus in cross‐section was 54.8, consisting of 24.1 endothelial cells, 16.0 podocytes, and 14.3 mesangial cells. In 5 selected nephritic rabbits, the mean total cell number of a glomerulus at the florid stage (7 to 12 experimental days) was 2.4 times as great as the control. It was revealed that the cells consisted of 27.9 endothelial cells, 14.9 podocytes, 21.1 mesangial cells, and 57.8 monocytic cells, indicating that about 76 per cent of the increased cells were of monocytic origin. Mesangial cells showed moderate increase in number (1.5 times) which persisted until 100 days, whereas endothelial cells increased only slightly. The monocytic cells promptly disappeared at 40 days correlating well with resolution of the proliferative change. Although the cellular compositions varied in each case, it was concluded that monocytes were essential in producing proliferative glomerular changes in the reversible type of Masugi nephritis. ACTA PATH. JAP. 29: 509–522, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00920.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The distribution and localization of immunoglobulin in the gastric mucosa and gastric cancer were studied by means of immunofluorescence. In the lamina propria of the stomach, like the other parts of the gastrointestinal tract, IgA producina cells predominated, but their population density varied from case to case. The main portion of secretion of IgA in the stomach was deep foveolar epithelium. IgA containing epithelial cells in the stomach were much less than those in the intestine, but they increased with advancement of intestinal metaplasia. Some gastric cancer cells retained the ability of secretory component production and took up IgA in their cytoplasm. ACTA PATH. JAP. 29: 523–531, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00921.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Extranodal formation of lymphoid follicles was morphologically studied in experimental bronchopneumonia. Control gnotobiotic mice had no peribronchial lymphoid follicles and only lymphatic vessels were traced from the terminal bronchiolar region toward larger bronchi. During the week after intranasal inoculation of mycoplasma pulmonis, lymphoid follicles developed in the terminal portion of the lymphatics by the accumulation of small lymphocytes. A loose network of mesenchymal cells and early infiltration of macrophages, following stromal edema, seemed to play an important role in the early accumulation of lymphocytes. Blastic transformation was seen frequently in the center of the accumulated lymphocytes. Two weeks after inoculation plasma cells emerged conspicuously in the periphery of the lymphoid follicles, and the acute phase of bronchopneumonia began to subside. Typical germinal centers with tingible body macrophages and dendritic reticulum cells developed when the bronchitis perisisted in a chronical manner. ACTA PATH. JAP. 29: 533–543, 197

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00922.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The early fine structural changes in the arteries of rats induced by excess vitamin D, perorally or parenterally were essentially similar, except the latter had a more prominent toxic effect to the vascular wall. The ultrastructural features, incidental to calcification, included the appearance of increased ground substance with a separation of collagenous and elastic fibrils, and degenerative changes in smooth muscle cells. Atherosclerosis was greatly accelerated at the sites of vascular injury when cholesterol, cholic acid and thiouracil were added to the basal diet. Calcification was initially observed in relation to elastic fibrils or degenerated cells in the upper and middle layers of the arteries, although there were few such deposits in the thickened intima of the coronary arteries. Calcium deposition could not be a direct effect of hypercalcemia, but the functional activity of smooth muscle cells did seem to promote the mineralization of calcium and phosphate. Furthermore, vitamin D‐induced sclerosis did not prevent intimal thickening of the arteries when vitamin D, was withdrawn. ACTA PATH. JAP. 29: 545–5562. 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00923.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Histological, histochemical and ultrastructural studies of the eosino‐philic globoid body of the human pancreas are described. It had a central cavity surrounded by a collarband measuring approximately 70 pm in diameter and is definitely different from cross section of small arteries. The complex ultrastructure was revealed with electron microscope in the eosino‐philic globoid body. This consisted of various patterns of unit membranes. Some of the bodies are probably derived from the membrane systems of the pancreatic acinar cells. ACTA PATH. JAP. 29: 563–570,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00924.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The kidneys from 62 proven liver cirrhosis cases were examined by immunofluorescence (IF), and 94% of the cases were positive for some immune reactants deposition. Combined deposition of immunoglobulin(s), both or each one of Clq and C4, and further with C3 were observed in about 70% of all IF positive cases. The morphological alterations of the glomeruli correlated with the intensities of regional immune reactants depositions. Guinea pig C3 was frequently activated in vitro on the glomeruli of these cases. Immune reactants depositions in the glomeruli appeared to form immune complex locally. Smooth muscle and liver cell antigens in the immune complex at the glomeruli were examined by indirect method of IF using monospecific antibodies and positive cases concerning each antigen were found in about 1/3 of the kidneys from 21 liver cirrhosis cases. These facts suggest that the high rate of the occurrence of immune com.plex deposition type glomerulo‐nephritis may be due to the glomerular deposition of some autoantigen‐antibody complexes including smooth muscle and liver cell antigens. ACTA PATH. JAP. 29: 571–583,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00925.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A case of chronic myelogenous leukemia (CML) associated with proliferation of atypical cells resembling those of reticulum cell sarcoma (RCS‐like cells) is presented. A number of immature eosinophils were present mingled with ordinary leukemic cells, which infiltrated in the bone marrow, lymph nodes, spleen, liver, lungs and testes. RCS‐like cells either formed solitary nodular foci or randomly mingled with infiltrating leukemic cells. Charcot‐Leyden crystals were seen in some areas where RCS‐like cells proliferated. As a peculiar feature the presence of eosinophilic granules in some of the RCS‐like cells was noted. They were proved to be immature form of specific granules of eosinophils by their staining properties and ultrastructural aspects. Based on these findings the myelogenous origin of RCS‐like cells is suggested. The patient died of cerebral complication of aspergillosis. ACTA PATH. JAP. 29: 58

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00926.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A case of malignant shwannoma is reported with unusual elements in an 89‐year‐old female. A large mass was located in the subcutaneous tissue of the right lateral chest wall and measured 5 cm in the greatest diameter. Histologically the tumor was composed of neurofibroma and malignant schwannoma with glandular differentiation. Neurofibroma characterized by numerous hyaline neural nodules was located in the peripheral portion of the tumor, whereas malignant schwannoma occupied a large part of the central portion of the tumor. The glandular elements observed in some areas of malignant schwannoma consisted of cuboidal and columnar shaped cells and were arranged in tubular or tubulo‐medullary fashion in which rosettes or pseudorosettes were found. Mucicarminophilic material was observed, both in the cytoplasm and in the lumen. Seven reported cases of peripheral nerve tumor with glandular differentiation are reviewed briefly. ACTA PATH. JAP. 29: 597–60

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00927.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Lupus nephritis in a sister and brother pair was histologically analyzed. The 12‐year‐old sister showed clinically progressive renal failure and her renal pathology disclosed segmental necrotizing and disorganizing glomeru‐lonephritis. On the contrary, the 14‐year‐old brother exhibited nephrotic syndrome and his renal biopsy showed diffuse exudative and proliferative glomerulonephritis with segmental membraneous changes. Although the familial incidence of SLE suggests both genetic and environmental factors existing in the background of SLE of identical twins and siblings, the differences of clinical manifestation and histopathological findings imply that there might be little direct genetic and environmental control on determining the expression of the disease. ACTA PATH. JAP. 29: 607

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00928.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

A case of tyrosinemia in a three‐month‐old boy is presented. The patient appeared jaundiced initially with markedly elevated levels of serum tyrosine and a positive Millon‐reacting urine. Jaundice persisted and hepatospleno‐megaly gradually increased. He died due to liver failure on the 51st day after admission. At autopsy, the liver showed the features of severe giant cell hepatitis including giant cell formation, fibrosis and bile retention. The pancreas and the brain showed characteristic postmortem Andings as previously reported in patients with tyrosinemia. ACTA PATH. JAP. 29: 615–

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1979.tb00929.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY