摘要:

The alpha subunit of human chorionic gonadotropin (HCG) was localized Immunohistochemically in paraffin sections of normal human tissues and neuroendocrine tumors. A small subset of dispersed neuroendocrine cells was positive in normal adult tissues, including gastric antrum, urachal remnant, anal glands and prostate. Positive cells were consistently present in perinatal lung but rare in adult lung. In contrast, the beta subunit was absent from these cells. Seventy two of 151 extrapituitary neuroendocrine tumors (48%) were alpha subunit positive. Thirty three of 37 bronchial carcinoids (92%) were immunore‐active, with a high percentage of the tumors (54%) containing moderate to large numbers of positive cells. The alpha subunit was further demonstrated in 9 of 45 small cell lung carcinomas (20%), 19 of 35 extrapulmonary carcinoids (54%), 3 of 11 islet cell tumors (27%) and 8 of 13 medullary thyroid carcinomas (62%). Two of three malignant islet cell tumors were positive. Positive cells were usually few in number, except for two small cell lung carcinomas, two rectal carcinoids, one thymic carcinoid and one malignant islet cell tumor. Pheochromocytomas (n=10) were negative. Eleven of 19 pulmonary tumorlets (58%) were alpha subunit immunoreactive. A few beta subunit positive cells were detected in only 6 lung lesions. The physiological significance of the imbalance of expression of HCG subunits by certain neuroendocrine cells and their tumors remains unknown. Acta Pathol Jpn 39: 413 419, 198

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02455.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The habits of smoking and drinking were investigated in relation to pathologic findings in the stomachs of 1,347 patients who had undergone surgery for gastric cancer at Toranomon Hospital between 1977 and 1986. There were 1,210 patients (807 males and 403 females) with single gastric cancer and 137 (117 males and 20 females) with multiple gastric cancer. The most frequent location of the tumor in cases of single gastric cancer was the middle third (47.8%), followed by the distal third (33.4%), upper third (13.1%) and cardiac region (5.7%). Tobacco consumption was positively associated with gastric cancer in males (odds ratio as the approximate relative risk = 2.8), whereas alcohol consumption was not. Neither tobacco nor alcohol consumption was positively associated with gastric cancer in females. Among male patients with single cancer, the habit of smoking was more prevalent in those with cancer of the cardia than in those with cancer of other portions of the stomach (p<0.01). Acta Pathol Jpn 39:420‐424, 198

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02456.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A histopathological study was performed on 36 patients (60 grafts) who had undergone aorto‐coronary bypass graft (ACBG) surgery 0 to 99 months prior to death. The following pathologic changes were found: 1) The thickness of diffuse intimal proliferation in the ACBG progressed with time from graft surgery to death. 2) The media became atrophic and the adventitia was increased slightly in thickness. 3) Fibrin deposits were found in 20 patients on/in the intimal thickenings of the vein graft walls and 7 patients showed incorporated fibrin in the thickened intima even one month after surgery. 4) Atherosclerosis, identified as intimal foam cell accumulation or frank plaques, was seen in only 3 patients 4 years after surgery. Fi‐brointimal proliferation occurred with relatively greater frequency in patients with fibrin deposits (P<0.001). Although it is well known that mural thrombi in vein grafts manifest fibrointimal proliferation, our results suggest that fibrin deposits might be responsible for intimal thickening even one month after graft surgery. Acta Pathol Jpn 39: 425 432, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02457.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Eighteen cases of primary thymic carcinoma were reviewed from the viewpoint of glandular differentiation. Squamous differentiation was evident in 14 cases (83%). Immunohistochemical study revealed secretory component (SC) positive carcinoma cells in 12 cases (67%), most of which were also associated with squamous differentiation. Three of these 12 cases contained areas with a definite glandular or microcystic structure with occasional epithelial mucin, and were diagnosed as adenosquamous carcinoma. Review of patients’medical records revealed that thymic carcinomas with a glandular element were more often resectable at surgery, and had a much better prognosis than those without a glandular element. However, further study on larger number of cases is necessary to confirm this relationship. Because SC positive epithelial cells do exist in the nonneoplastic thymus, the presence of a glandular component suggests another direction of morphological and/or functional differentiation of thymic carcinoma cells in addition to the well‐known squamous differentiation. Acta Pathol Jpn 39: 433 438, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02458.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Osteosarcoma in the metaphysis to epiphysis of the left femur of a 17 year old male is reported. The lesion appeared osteolytic with sclerotic foci on roentgenographs, accompanied by an extensive tumor shadow in the surrounding soft tissue. While 60% of the tumor was necrotic, histological examination of the remaining viable tissue revealed that it consisted almost entirely of a sheet of epithelioid cells, separated by thin, fibrovascular septa with an alveolar‐like pattern, suggestive of metastatic carcinoma. Only a few areas were characterized by malignant osteoid tissue intermingled with the above cells, showing significant positivity for bone‐specific alkaline phosphatase and 5 nucleotidase, thus permitting a diagnosis of osteosarcoma. Autopsy findings revealed that the metastatic foci were histologically similar to those of the primary tumor. Electron microscopy revealed poor development of cytoplasmic organelles, supporting possible derivation from an osteoblastic cell lineage at an early stage. Acta Pathol Jpn 39: 439 445, 1

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02459.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

An autopsy case of malignant midline reticulosis (MMR) is reported. The patient, a 42 year old Japanese male, died after a clinical course of 22 months. Autopsy revealed extensive infiltration of generalized organs by the tumor cells, suggesting that the disease was highly malignant in nature. Staining with monoclonal antibodies against T cell surface antigens Leu 4 on frozen sections and UCHL1 on paraffin embedded sections enabled us to examine the phenotype of the tumor cells with good morphological preservation and to verify the T cell nature of the tumor. Acta Pathol Jpn 39: 446 450, 1989.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02460.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Histological and ultrastructural findings obtained upon examination of a liver biopsy specimen from a 2 year old girl with primary ornithine transcarbamylase (OTC) deficiency are presented. The OTC activity in the hepatic tissue of the patient was 7% that of the normal level. Light microscopic observation showed diffusely swollen hepatocytes with pale or empty cytoplasm due to accumulation of glycogen. Neither fat degeneration nor necrosis was evident. Electron microscopy revealed strikingly abnormal hepatocyte mitochondria, which showed marked polymorphism with elongation and enlargement, ring or dumbbell shaped configurations, and irregular distribution and shortening of the cristae. Mitochondria showing degenerative alterations such as swelling and rarefaction, which have been reported in cases of Reye's syndrome, were present, but their number was very small. Other organelles showed no remarkable change. It is suggested that the mitochondrial changes seen in OTC deficiency are essentially different from those in Reye's syndrome, which otherwise is clinically and biochemibcally very similar to OTC deficiency. Acta Pathol Jpn 39: 451 456, 1989.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02461.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Two cases of mesonephric duct hyperplasia of the uterus, together with three cases of uterine mesonephric duct remnant, are reported. The latter cases were identified by serial transverse sectioning of 42 surgically resected uteri, yielding a frequency of approximately 7%. Histochemical studies showed no mucin in the cytoplasm of cells lining the mesonephric duct remnant, as well as mesonephric duct hyperplasia. In contrast, the endocervical epithelium had abundant neutral mucin, sialomucin and sulfomucin. Im‐munohistochemical studies on lectin binding showed positive binding of PNA and SBA lectins only to the lining cells of mesonephric duct hyperplasia. Acta Pathol Jpn 39: 457 464, 198

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02462.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

An autopsy case of glycogen‐rich clear cell carcinoma (GRCCC) which arose i n the right breast of a 72‐year‐woman is reported. Light microscopic examination of small finger‐tip‐sized tumor revealed solid alveolar proliferation of clear cells containing abundant glycogen. munohistochemically, most of the clear tumor cells were stained for epithelial membrane antigen (EMA) and alphalactalbumin, whereas a few eosinophilic tumor cells were positive for S‐100 protein, EMA and actin. Electron microscopically, aggregates of glycogen particles, numerous empty glycogen lakes, microvilli, tight junctions and basal lamina were identified. Autopsy disclosed marked metastases to the liver, lung, adrenal, skin and lymph nodes. Primary breast cancer was confirmed by exclusion of primary at any other site. It is suggested that although rare, GRCCC of the breast is as aggressive as usual invasive ductal carcinoma, and is associated with severe nodal and blood‐borne metastases, followed by death. Acta Pathol Jpn 39 :

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02463.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

An autopsy case of glycogen‐rich clear cell carcinoma (GRCCC) which arose in the right breast of a 72 year old woman is reported. Light microscopic examination of the small finger tip‐sized tumor revealed solid alveolar proliferation of clear cells containing abundant glycogen. Im‐munohistochemically, most of the clear tumor cells were stained for epithelial membrane antigen (EMA) and alpha lactalbumin, whereas a few eosinophilic tumor cells were positive for S 100 protein, EMA and actin. Electron microscopically, aggregates of glycogen particles, numerous empty glycogen lakes, microvilli, tight junctions and basal lamina were identified. Autopsy disclosed marked metastases to the liver, lung, adrenal, skin and lymph nodes. Primary breast cancer was confirmed by exclusion of a primary at any other site. It is suggested that although rare, GRCCC of the breast is as aggressive as usual invasive ductal carcinoma, and is associated with severe nodal and blood borne metastases, followed by death. Acta Pathol Jpn 39: 469 472,

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1989.tb02464.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY