摘要:

Mitochondria, rough endoplasmic reticulum, Golgi apparatus and other cytoplasmic organelles were found within the nuclei, not in ‘nuclear pseudo‐inclusions’, of some cells in several hematopoietic disorders. Mitoses were fairly often observed in the atypical cells of these cases. We suggest that these intranuclear cytoplasmic organelles may be trapped in the nucleus during an abnormal mi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00890.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Findings of perivascular mesenchymal cells and fibroblasts in mice receiving large doses of vitamin A were described. Liver, lung, intestine and skin were investigated by fluorescence and electron microscopy. Marked increase of fluorescence of vitamin A was observed in the sinusoidal wall of the liver, in the alveolar septa of the lungs, in the propria mucosa, submucosa and muscular layer of the intestine and in the dermis of the abdominal skin. Increased fluorescence of these organs corresponded, ultrastructually, to the appearance of numerous fat droplets in Ito cells of the liver, septal cells of the lung and fibroblasts of the intestine and of the skin. All of these cells showed the same morphological features and the same distribution in the tissue, namely in the interstitial connective tissue space. These findings indicate that vitamin A storing cells are distributed widely in the connective tissue of various organs and that perivascular vitamin A storing mesenchymal cells and interstitial fibroblasts are probably of common fibroblastic cell line.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00891.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The oral administration of N,'N‐2,7‐fluorenylenebis‐acetamide (2,7‐FAA) induces leukemia, especially mature granulocytic leukemia in rats. We compared the degree of infiltration of 2,7‐PAA‐induced mature granulocytic leukemia with that of transplanted leukemia for the purpose of proving hema‐togenous development of leukemia. The bone marrow, spleen and liver were examined in the cases of diffuse lesion of 2,7‐FAA‐induced and transplanted leukemia. The average degree of infiltration of both 2,7‐PAA‐induced and transplanted leukemia was high in the bone marrow, medium in the spleen, and low in the liver. Intravenous transplantation of malignant neoplasm is an example of hematogenous metastasis. The similarity of infiltration between 2,7‐FAA‐induced and transplanted leukemia suggests that the former is spread b

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00892.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Oral administration of N,N'‐2,7‐fluorenylenebis‐acetamide (2,7‐PAA) induces mature granulocytic and erythroblastic leukemia in rats. We compared the primary site of mature granulocytic leukemia with that of erythroblastic leukemia. The nodular foci of solitary lesions and conspicuously large foci of scattered lesions were considered to be the primary site. They appeared mainly in the bone marrow of various bones. The primary site of mature granulocytic leukemia appeared more frequently in short bones than in long bones. On the contrary, that of erythroblastic leukemia appeared more frequently in long bones than in short bones. The origin of mature granulocytic leukemia seems to be concerned with bone tissue, while erythroblastic leukemia may have little relation with bone

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00893.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Age‐associated architectural changes of the human testicular micro‐vasculature from 70 autopsy cases were stereoscopically examined with a silicone‐rubber injection technique. In the testis of a young subject, the interlobular main arteries run straight. The coiling phenomena of the interlobular centripetal or centrifugal arteries, which are commonly seen in adult testis, have been so far considered as physiological transformation of the vasculature. It was confirmed that the coiling changes in the interlobular main arteries of the human testis appear as an age‐dependent alteration of the vasculature closely related to the volume of the gland. The practical importance of the spiralling or coiling of arteries is that it results in a considerable reduction of blood flow. The age‐related coiling of the interlobular arteries is virtually accompanied by varying degrees of collapse of the peritubular capillary networks. The reduction of blood supply to the seminiferous tubules plays an active role in promoting aging of the testis. These stereoscopical observations of age‐related transfiguration of testicular microvasculature were ascertained also by histometrical e

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00894.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Repair processes of the aortic wall have been studied electron microscopically after removal of the endothelium by an inflated balloon procedure in the thoracic aortae of swine. Initial responses after injury included a thrombotic reaction, the appearance of intimal cells over the denuded surface, and increased mitotic activity of medial cells adjacent to the dead cells by day 3. Cells which engaged in intimal thickening were classified as modified smooth muscle cells throughout the course of this investigation. Mitosis of intimal cells, which was initially observed at day 3, substantially increased at day 7 and decreased by day 14. Mitotic intimal cells contained the same cytoplasmic organelles as interphase modified smooth muscle cells. A detailed description of the paired cisternae as an ultrastructural feature of cell division of modified smooth muscle cells was provided. The paired cisternae were initially observed among the remnants of the nuclear envelope in late prophase; they remained at the periphery of the mitotic apparatus in meta‐ and anaphase, and finally attached themselves to the nuclear envelope of the daughter cells in late telophas

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00895.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

This study consists of 83 autopsy cases including 64 prolonged cases of Minamata disease. Lesions were severe in the prolonged cases with an acute onset, while they tended to be mild in those with chronic onset. Cerebral cortex showed loss of nerve cells in many of the former, with the cortex often being in a loosening or spongy state, while the thinning‐out or decrease of neurons not exceeding 30% of all cells was frequent in the latter. Glial reaction was also intense in the former, but relatively weak in the latter; gradual loss of degenerative neurons without glial reaction was not rare. A given selectivity was found in the localization of lesions of the cerebral cortex, but it was not so conspicuous in those with a chronic onset as in those with an acute onset. Secondary changes corresponding to the lesions of the cortex appeared in the medulla.Cerebellar lesions in the chronic onset cases, as compared with those in the acute onset ones, were milder: the selectively localized area was diminished; the nodulus, uvula and lingula of the vermis and the medial surface of the semilunar lobules were the most likely to be damaged. Of the spinal peripheral nerves, damages to the spinal sensory nerve were found, which were more predominant than those to the motor nerve system, and in which was noted prominent regeneration and repair.The deposited mercury found in organs tended to remain in the nervous system and the kidneys during the prolonged course of this disease, and the prolonged accumulation of mercury in the nervous system appeared to have an influence on the pathogenesis of chronic Minamata diseas

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00896.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An autopsy cases of Menkes kinky hair disease in a 1 year and 8 months old male infant is presented and compared with the morphological findings of the previous literatures. The main pathological changes are atrophy of the whole cerebellar cortex and bilateral temporal lobe, atrophy with demyelination of the white matter, tortuous running of the cerebral arteries, multiple diverticulosis of the urinary bladder and hyaline‐like deposition in the gastric submucosa. Microscopically, the peculiar degenerative change of Purkinje cell (somal sprout) is the only characteristic lesion in our case and the others. It is suggested that Menkes kinky hair disease may be a syndrome due to metabolic disturbance appearing not only in ectoderm such as the central nervous system, but also in mesoderm such as connective tissue and bon

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00897.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Two autopsy cases, a 77‐year‐old man and a 66‐year‐old woman, of cardiovascular amyloidosis with many giant cells were reported. These cells were always found adjacent to amyloid masses which were deposited mainly in small arteries and arterioles, and some of them contained amyloid substance in their cytoplasms. The incidence of these cells was high in the heart and in the kidneys of both cases, and in the latter case the cells were found in the majority of the organs varying in degree. The significance of the giant cells, which probably originated from macrophages, were discussed and that giant cells might appear as a foreign body reaction to amyloid substance was p

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00898.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Hemangiosarcoma of the breast in a 22‐year‐old female was presented. She died of massive pulmonary metastasis and apparent internal hemorrhage from the involved liver by metastasis after 40 months of the illness. Intense scanning electron microscopic (SEM) study was undertaken on this lesion. At the same time, in order to compare SEM findings of angiosarcoma with several other benign disorders, the following lesions were chosen, namely, chronically‐inflamed veins in the gastric submucosa, benign cavernous hemangiomas of the skin and liver, and organizing thrombi with papillary structures. Some of these lesions exhibited focal similarities in surface structures to those from angiosarcoma. Besides various characteristics by SEM in angiosarcoma, cell clusters protruding into the vascular cavity were found to be the most unique feature which we have never observed in any other le

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00899.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY