摘要:

Senile aortic amyloidosis in 224 autopsy cases over 40 years was investigated comparing cardiac and pancreatic amyloidosis in them. A total of 176 cases of aortic amyloidosis was found for an average incidence of 79%. Under the 5th decade the incidence was 51% and it rose sharply with age and reached 95% in over the 8th decade. The incidence of cardiac amyloidosis also increased with age, but it was always higher in the aorta. Aortic and cardiac amyloid were both positive in the DMAB method for tryptophan. The major part exposed to amyloidosis in the aorta was the media. The medial amyloid consisted of numerous minute deposits and had no relation to atherosclerosis. Some comments about the pathogenesis of senile amyloidosis were also mentioned.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00531.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Megamitochondria were induced within 36‐40 hours in mouse hepatocytes by injecting cuprizone into the peritoneal cavity. Induction of megamitochondria was dependent upon the amount and the time intervals of the injection of cuprizone: 200 mg of cuprizone/kg of body weight ‐ injected every 12 hours or 400 mg of cuprizone/kg of body weight ‐ injected every 24 hours. When the latter amount of the noxious reagent was administered to the animal every 12 hours, fatty changes of the liver was observed. Involvement of the fusion phenomenon in the mechanism of megamitochondrial formation is discussed in the light of turnover rates for various components of the mitochon

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00532.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Effect of cuprizone has been studied on some biochemical properties of megamitochondria obtained from the mouse liver. (1) Contents of Ca2+, Mg2+and Cu2+in the blood or the liver homogenates were not altered by cuprizone‐intoxication, whereas those in liver mitochondria were significantly altered: after 3‐4 days’intoxication, content of Ca2+was decreased and was remarkably increased after 14‐15 days’intoxication. Content of Mg2+behaved contrarily. (2) Both cytochrome oxidase and ATPase activities were unchanged in the liver megamitochondria, but monoamine oxidase (MAO) activity was significantly decreased. Value of I50(50% inhibition) for MAO was determined to be 0.33 mM using the control liver mitochondria. Cuprizone had almost no effect on MAO activity of kidney or heart mitochondria bothin vivoandin vitro. (3) The amount of lysolecithin was increased in the liver megamitochondria.These results were discussed in the light of membrane fusion phenomenon which plays a key role in the mechanism of megamitochondrial

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00533.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

To confirm the existence and to analyse the distribution of the melanocyte in cystic teratoma of the ovary, 51 cases were collected, among which 47 were found suitable for gross and histological examinations. The tissue components of cystic teratoma where the melanocyte was seen more or less associating were; the squamous, cuboidal and columnar cell epithelia especially the epidermal epithelium, the brain tissue principally the leptomeninx, and the interstltium. The frequency of melanocytes’association in the respective tissue was shown and compared between each other. One thing which was quite interesting for us was the relationship between the existence of brain tissue and the development of melanocyte in cystic teratoma. The melanocyte appeared in the above tissues, especially the Interstltium, of cystic teratoma more frequently when the brain tissue was coexisting in the same tumor. These findings seem to be of meaningful suggestions concerning the melanocy‐togenesis not only of cystic teratoma of the ovary, but also in a physiological condition in

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00534.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Rickettsia‐llke bodies were reportedly found in biopsies of the skin and lymph nodes from half the number of patients with Kawasaki's disease. In our present work, these microbodies were isolated from the peripheral whole blood of a patient with Kawasaki's disease (MLNS) through passage of guinea pigs and yolk sac culture. However, the isolated strains disappeared spontaneously during their stores at −80°G for two w

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00535.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

NBT (Nitroblue Tetrazolium) test was performed in 17 patients with Kawasaki disease to examine the function of phagocytosis and intra‐cellular killing of neutrophils. The value was high compared to other pediatric patients. Activation with Proteus OX‐2 antigen before NBF test showed a significant higher level than other proteus antigens, which correspond in serum level. With previous electronmicroscopic observation of rickettsiallke body in biopsy specimen, these findings suggest the existence of an agent in Kawasaki disease which shares antigenicity with Proteus O

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00536.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The author has investigated grossly and microscopically 12 cases (5 males and 7 females) of dissecting aneurysm in individuals under 40 years of age, autopsied during the last 6 years at the Tokyo‐to Medical Examiner Office. They composed of 6 cases of Marfan's syndrome, 3 cases of obesity, and one case each of pregnancy, aortitis syndrome, and male pseudohermaphroditism, respectively. The 6 cases other than Marfan's syndrome were also thought to belong to the Marfan group from the gross and microscopic examinations of the aorta. As to the cases of dissecting bleeding of the aorta, Erdheim's idiopathic cystic medial necrosis was as a rule authentical up to date, but the author has never observed the bleeding within the cysts which were said to be formed due to accumulation of metachromatic ground substance. On the contrary, the medial bleeding occurred always in the weakened area in where the elastic fibers were disrupted and disappeared accompanying with the diminution of metachromatic substance. The author assumed that the diminution of metachromatic substance might be the most important etiologlc factor of dissecting bleeding of the media and the extension of dissection might occur along such weakened foci of the medi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00537.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The effect caused by the double condition of potassium loading (K loading) and simultaneous sodium restriction (Na restriction) on the glomerular zone of rats is reported. After 2‐week‐diet of K loading and simultaneous Na restriction an increase of width of glomerular zone and decreases and micronization of fat granules were seen. Enzymic activity (glucose‐6‐phosphate dehydrogenase, steroid 3ß‐ol‐dehydrogenase) was increased. After 3‐week‐diet of the same condition the width of glomerular zone became 1/4 to 1/5 of the whole cortex. The cells in the glomerular zone demonstrated a trabecular arrangement. Ultrastructurally, hypertrophy of cells became marked and the size of cell was about 1.5 times that of normal cells. Dense body increased in number and became irregular in shape. In the widened cytoplasm, smooth endoplasmic reticulum and Golgi apparatus were well developed with numerous coated vesicles. Changes of mitochondria such as increase in number, transformation into round shape and vesicular cristae were characteristic. The severity of these changes was proportional to the duration of K loading and simultaneous Na restriction. After 8‐week‐diet the increase of large‐sized lipid vacuole and dense body, and intramitochondrial deposition were observed in parallel with the above‐mentioned changes. The changes observed in this study appeared earlier and stronger than those in the single‐conditioned group of only K loading or Na restriction. The cause of these changes were considered to be a result of accelerated functi

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00538.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Thromboplastic and fibrinolytic activities of V2 and V7 carcinomas, the two transplantable rabbit tumors of the same viral origin, were studied in relation to fibrin deposition and thrombus formation in the tumors. Thromboplastic activity of V7 carcinoma was comparatively high, while that of V2 carcinoma was as low as that of muscle tissue. More fibrin deposits in the stroma and more thrombi in the small vessels were found at the advancing border of V7 carcinoma than that of V2 carcinoma. These differences might be associated with higher thromoboplastic activity of V7 carcinoma than that of V2 carcinoma. Fibrinolytic activity of both tumors was high and it was confirmed to be localized in the tumor cells by Todd's method. Fibrin deposits in the stroma were found more abundantly somewhat apart from the advancing border of the tumor nests of both tumors. It was suggested that plasmin activated by plasminogen activator released locally from the tumor cells might digest fibrin deposited in the stroma just close to the tumor nests.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00539.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

An autopsy case with the syndrome of combined congential defects involving the supraumbilical abdominal wall, sternum, diaphragm, pericardium, and heart is reported. In this case, abnormal arterial plexus including anastomosis of the left coronary artery and the left internal mammary artery is recognized at the hernial pericardial wall, in addition to the already reported anomaly complex, i.e. diastasis recti abdominis with pericardial hernia, ventral defect of the diaphragm, partial defect of the sternum, and tetralogy of Fallot. It is suggested that this newly revealed vascular anomaly also comes within a specific syndrome of combined congenital defects.

ISSN:1320-5463    

DOI:10.1111/j.1440-1827.1978.tb00540.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY